The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors
Open accessAbstract
Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on a proteolytic-enzyme nanoparticle system disassembles the dense PDAC collagen stroma and increases drug penetration into the pancreatic tumor. More specifically, the collagozome, a 100 nm liposome encapsulating collagenase, was rationally designed to protect the collagenase from premature deactivation and prolonged its release rate at the target site. Collagen is the main component of the PDAC stroma, reaching 12.8 ± 2.3% vol in diseased mice pancreases, compared to 1.4 ± 0.4% in healthy mice. Upon intravenous injection of the collagozome, ∼1% of the injected dose reached the pancreas over 8 h, reducing the level of fibrotic tissue to 5.6 ± 0.8%. The collagozome pretreatment allowed increased drug penetration into the pancreas and improved PDAC treatment. PDAC tumors, pretreated with the collagozome followed by paclitaxel micelles, were 87% smaller than tumors pretreated with empty liposomes followed by paclitaxel micelles. Interestingly, degrading the ECM did not increase the number of circulating tumor cells or metastasis. This strategy holds promise for degrading the extracellular stroma in other diseases as well, such as liver fibrosis, enhancing tissue permeability before drug administration.
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Cites
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Extracellular matrix and its therapeutic potential for cancer treatment
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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments
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Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity
Li, Y., Chen, W., Kang, Y., Zhen, X., Zhou, Z., Liu, C., Chen, S., Huang, X., Liu, H.-J., Koo, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42509-7 · Cited by 235
Metadata
- Authors
- Zinger, A., Koren, L., Adir, O., Poley, M., Alyan, M., Yaari, Z., Noor, N., Krinsky, N., Simon, A., Gibori, H., Krayem, M., Mumblat, Y., Kasten, S., Ofir, S., Fridman, E., Milman, N., Lübtow, M. M., Liba, L., Shklover, J., Shainsky-Roitman, J., Binenbaum, Y., Hershkovitz, D., Gil, Z., Dvir, T., Luxenhofer, R., Satchi-Fainaro, R., & Schroeder, A.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-09-10
- Volume
- 13
- Issue
- 10
- Pages
- 11008-11021
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2972690193
- Cited by
- 323
- References
- 62
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Zinger, A., Koren, L., Adir, O., Poley, M., Alyan, M., Yaari, Z., Noor, N., Krinsky, N., Simon, A., Gibori, H., Krayem, M., Mumblat, Y., Kasten, S., Ofir, S., Fridman, E., Milman, N., Lübtow, M. M., Liba, L., Shklover, J., . . . Schroeder, A. (2019). Collagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors. ACS Nano. https://doi.org/10.1021/acsnano.9b02395
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
