The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration
Abstract
The simultaneous therapy of tumors and bone defects resulting from tumor surgery is still a challenge in clinical orthopedics. Few nanomaterial systems simultaneously possess multifunctional capacities, including biodegradability, tumor treatment, and enhanced bone regeneration. Herein, we designed a biodegradable monodispersed bioactive glass nanoparticle (BGN) platform with multifunctional properties for enhanced colon cancer photothermo-chemotherapy and bone repair. The mussel-inspired surface assembly with BGN was established as a stable NIR-excited photothermal nanoplatform (BGN@PDA) for ablating tumors. BGN@PDA shows an ultrahigh anticancer drug (DOX) loading with on-demand (pH/NIR-responsive) drug release behavior and antibacterial activity for enhanced tumor chemotherapy (BGN@PDA-DOX). The growth of colon cancer cells (Hct116 cells) and cervical cancer cells (HeLa cells) was significantly inhibited in vitro, and superior local anticancer efficacy could be achieved by synergic chemo-photothermal therapy in vivo . BGN@PDA underwent a gradual degradation in vivo during 60 days and showed negligible toxic side effects. Meanwhile, BGN@PDA could positively induce the osteogenesis of osteoblasts in vitro and possess excellent in vivo bone repair ability in rat cranial defects. This work presents a distinctive strategy to design a bioactive multifunctional nanoplatform for treating tumor disease-resulted bone tissue regeneration.
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Liu, Y., Ai, K., & Lu, L. (2014) · Chemical Reviews · doi:10.1021/cr400407a · Cited by 4,794
The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
Polydopamine Surface Chemistry: A Decade of Discovery
Ryu, J. H., Messersmith, P. B., & Lee, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19865 · Cited by 1,843
Cited by
Xi, Y., Ge, J., Wang, M., Chen, M., Niu, W., Cheng, W., Xue, Y., Lin, C., & Lei, B. (2020) · ACS Nano · doi:10.1021/acsnano.9b07173 · Cited by 346
Self-citationLiao, J., Shi, K., Jia, Y., Wu, Y., & Qian, Z. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.01.006 · Cited by 181
Wu, M., Chen, F., Liu, H., Wu, P., Yang, Z., Zhang, Z., Su, J., Cai, L., & Zhang, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100458 · Cited by 55
Zhang, M., Mi, M., Hu, Z., Li, L., Chen, Z., Gao, X., Liu, D., Xu, B., & Liu, Y. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s473007 · Cited by 31
Gu, M., Jiang, L., Hao, L., Lu, J., Liu, Z., Lei, Z., Li, Y., Hua, C., Li, W., & Li, X. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01136g · Cited by 30
Metadata
- Authors
- Xue, Y., Niu, W., Wang, M., Chen, M., Guo, Y., & Lei, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-11-08
- Volume
- 14
- Issue
- 1
- Pages
- 442-453
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2983042458
- Cited by
- 165
- References
- 3
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- closed
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