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Cited by 31Polymer Surface Interaction StudiesBone Tissue Engineering MaterialsSurgical Sutures and Adhesives

Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives

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Zhang, Min, Mi, Man, Hu, Zilong, Li, Lixian, Chen, Zhiping, Gao, Xiang, Liu, Di, Xu, Bilian +1 more·2024·Drug Design, Development and Therapy
DOI 10.2147/dddt.s473007PMC PMC11363944
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Abstract

Polydopamine is a versatile and modifiable polymer, known for its excellent biocompatibility and adhesiveness. It can also be engineered into a variety of nanoparticles and biomaterials for drug delivery, functional modification, making it an excellent choice to enhance the prevention and treatment of orthopedic diseases. Currently, the application of polydopamine biomaterials in orthopedic disease prevention and treatment is in its early stages, despite some initial achievements. This article aims to review these applications to encourage further development of polydopamine for orthopedic therapeutic needs. We detail the properties of polydopamine and its biomaterial types, highlighting its superior performance in functional modification on nanoparticles and materials. Additionally, we also explore the challenges and future prospects in developing optimal polydopamine biomaterials for clinical use in orthopedic disease prevention and treatment.

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  • PDA-AgNP composite coatings integrate the favorable biocompatibility of PDA with the potent broad-spectrum antibacterial activity of AgNPs, enabling sustained silver ion release for long-term suppression of oral pathogenic bacteria.

    “The resulting PDA–AgNP composite coatings integrate the favorable biocompatibility of PDA with the potent broad-spectrum antibacterial activity of AgNPs, enabling sustained silver ion release for long-term suppression of oral pathogenic bacteria.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [67]

    The Introduction describes PDA’s biocompatibility and says PDA-coated nanoparticles can be tailored for sustained release; the References list antibacterial PDA–silver materials. But the paper’s discussion does not establish sustained silver-ion release from these coatings or long-term suppression of oral pathogenic bacteria. The subgingival result in the bone-reconstruction section concerns PDA’s removal of reactive oxygen species, not antibacterial effects of PDA–AgNP coatings. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • The presence of PDA mitigates the cytotoxic effects commonly associated with silver-based antibacterial systems.

    “Importantly, the presence of PDA mitigates the cytotoxic effects commonly associated with silver-based antibacterial systems.31,66,67”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [67]

    The Introduction describes PDA as having low cytotoxicity and mentions its combination with silver nanoparticles, but it does not say PDA reduces the cytotoxicity of silver-based antibacterial systems. A targeted search for silver toxicity and PDA-mediated mitigation found no passage making that comparison in our copy. (LLM, conf=0.72)

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References 408 · Cited by 31

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200 of 398 shown

Authors
Zhang, M., Mi, M., Hu, Z., Li, L., Chen, Z., Gao, X., Liu, D., Xu, B., & Liu, Y.
Affiliations
Guangdong Medical College (CN)
Corresponding author
  • Xu, Bilian
  • Liu, Yanzhi
ORCID
Venue
Drug Design, Development and Therapy
Publisher
Informa UK Limited
Published
2024-08
Volume
Volume 18
Pages
3765-3790
ISSN
1177-8881 (ISSN-L)
DOI
10.2147/dddt.s473007
PMC
PMC11363944
OpenAlex
W4401867578
Cited by
31
References
408
Citations by year
2026: 16 · 2025: 15
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
Locations
  • Drug Design Development and Therapy (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • National Natural Science Foundation of China (81703584)
  • Natural Science Foundation of Guangdong Province (2021A1515010975)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
polydopamine, biomaterials, drug delivery, nanoparticles, surface functionalization, biocompatibility
MeSH terms
Animals, Biocompatible Materials, Humans, Indoles, Polymers, Drug Delivery Systems, Nanoparticles

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