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Cited by 122Microplastics and Plastic PollutionEnvironmental Toxicology and EcotoxicologyZebrafish Biomedical Research Applications

Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish ( Danio rerio )

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Feng, Meilan, Luo, Juanjuan, Wan, Yiping, Zhang, Jiannan, Lu, Chunjiao, Wang, Maya, Dai, Lu, Cao, Xiaoqian +2 more·2022·ACS Omega
DOI 10.1021/acsomega.2c03378PMC PMC9476205
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Abstract

, were altered in zebrafish embryos for 24 h after nanoplastic exposure, indicating that the activation of the BER pathway would be stimulated after nanoplastic exposure in zebrafish embryos. Therefore, our findings illustrated that nanoplastics could induce developmental toxicity through activation of the oxidative stress response and BER pathways in zebrafish.

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  • Extensive research has investigated the toxic effects of polystyrene nanoparticles on aquatic organisms, primarily focusing on oxidative stress and inflammation.

    “Extensive research has investigated the toxic effects of polystyrene nanoparticles on aquatic organisms, primarily focusing on oxidative stress and inflammation (Feng et al., 2022; Pei et al., 2022; Wu et al., 2022).”

    From Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution (2025) · cites this paper as Feng et al., 2022

    The Conclusions (page unavailable) report oxidative stress in zebrafish exposed to polystyrene nanoplastics and suggest that inflammation may contribute to DNA damage. The Introduction also discusses oxidative stress and inflammation, but largely in relation to microplastics. These passages do not establish that extensive research on polystyrene nanoparticles in aquatic organisms has primarily focused on both responses. (LLM, conf=0.82)

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Sorted by citations

Authors
Feng, M., Luo, J., Wan, Y., Zhang, J., Lu, C., Wang, M., Dai, L., Cao, X., Yang, X., & Wang, Y.
Affiliations
  • Sichuan University (CN)
  • Shantou University (CN)
Corresponding author
  • Yang, Xiaojun
  • Wang, Yajun
ORCID
Venue
ACS Omega
Publisher
American Chemical Society (ACS)
Published
2022-08-31
Volume
7
Issue
36
Pages
32153-32163
ISSN
2470-1343 (ISSN-L)
DOI
10.1021/acsomega.2c03378
PMC
PMC9476205
OpenAlex
W4293842883
Cited by
122
References
4
Citations by year
2026: 37 · 2025: 35 · 2024: 28 · 2023: 21 · 2022: 1
FWCI
5.05
Type
journal article
Language
en
Open access
Licence
Locations
  • ACS Omega (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Guangdong Science and Technology Department (210728156901639)
  • National Natural Science Foundation of China (32072706, U1901206)
Topics
  • Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Keywords
polystyrene nanoparticles, nanoplastic exposure, developmental toxicity, oxidative stress response, base excision repair, zebrafish embryos, DNA damage, embryonic development

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