Cited by 256Electrochemical sensors and biosensorsAdvanced Sensor and Energy Harvesting MaterialsAdvanced biosensing and bioanalysis techniques

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Epidermal Enzymatic Biosensors for Sweat Vitamin C: Toward Personalized Nutrition

Sempionatto, Juliane R., Khorshed, Ahmed A., Ahmed, Aftab, De Loyola e Silva, Andre N., Barfidokht, Abbas, Yin, Lu, Goud, K. Yugender, Mohamed, Mona A., Bailey, Eileen, May, Jennifer, Aebischer, Claude, Chatelle, Claire, Wang, Joseph·2020·ACS Sensors

DOI 10.1021/acssensors.0c00604

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Abstract

Recent advances in wearable sensor technologies offer new opportunities for improving dietary adherence. However, despite their tremendous promise, the potential of wearable chemical sensors for guiding personalized nutrition solutions has not been reported. Herein, we present an epidermal biosensor aimed at following the dynamics of sweat vitamin C after the intake of vitamin C pills and fruit juices. Such skin-worn noninvasive electrochemical detection of sweat vitamin C has been realized by immobilizing the enzyme ascorbate oxidase (AAOx) on flexible printable tattoo electrodes and monitoring changes in the vitamin C level through changes in the reduction current of the oxygen cosubstrate. The flexible vitamin C tattoo patch was fabricated on a polyurethane substrate and combined with a localized iontophoretic sweat stimulation system along with amperometric cathodic detection of the oxygen depletion during the enzymatic reaction. The enzyme biosensor offers a highly selective response compared to the common direct (nonenzymatic) voltammetric measurements, with no effect on electroactive interfering species such as uric acid or acetaminophen. Temporal vitamin C profiles in sweat are demonstrated using different subjects taking varying amounts of commercial vitamin C pills or vitamin C-rich beverages. The dynamic rise and fall of such vitamin C sweat levels is thus demonstrated with no interference from other sweat constituents. Differences in such dynamics among the individual subjects indicate the potential of the epidermal biosensor for personalized nutrition solutions. The flexible tattoo patch displayed mechanical resiliency to multiple stretching and bending deformations. In addition, the AAOx biosensor is shown to be useful as a disposable strip for the rapid in vitro detection of vitamin C in untreated raw saliva and tears following pill or juice intake. These results demonstrate the potential of wearable chemical sensors for noninvasive nutrition status assessments and tracking of nutrient uptake toward detecting and correcting nutritional deficiencies, assessing adherence to vitamin intake, and supporting dietary behavior change.

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Authors: Sempionatto, J. R., Khorshed, A. A., Ahmed, A., De Loyola e Silva, A. N., Barfidokht, A., Yin, L., Goud, K. Y., Mohamed, M. A., Bailey, E., May, J., Aebischer, C., Chatelle, C., & Wang, J.
Affiliations: University of California San Diego (US)
University of California , , La Jolla, , ,
DSM (Switzerland) (CH)
Corresponding author: Wang, Joseph
ORCID: Sempionatto, Juliane R.
Ahmed, Aftab
Barfidokht, Abbas
Yin, Lu
Goud, K. Yugender
Mohamed, Mona A.
Bailey, Eileen
Chatelle, Claire
Wang, Joseph
Venue: ACS Sensors
Publisher: American Chemical Society (ACS)
Published: 2020-05-05
Volume: 5
Issue: 6
Pages: 1804-1813
ISSN: 2379-3694 (ISSN-L)
DOI: 10.1021/acssensors.0c00604
OpenAlex: W3023922670
Cited by: 256
References: 37
Citations by year: 2026: 24 · 2025: 34 · 2024: 44 · 2023: 56 · 2022: 48 · 2021: 31 · 2020: 19
FWCI: 13.21
Type: journal article
Language: en
Open access: closed
Licence: doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-045 (stm-asf)
Locations: ACS Sensors (publishedVersion)
PubMed (publishedVersion)
Funders: Higher Education Commision, Pakistan (1-8/HEC/HRD/2018/8205)
US-UK Fulbright Commission (ay2019-2020)
Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (216981/2014-0)
United States Agency for International Development
DSM Nutritional Products
Topics: Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
Keywords: ascorbate oxidase, personalized nutrition, dietary adherence, nutritional deficiency
MeSH terms: Ascorbic Acid, Humans, Nutritional Status, Sweat, Vitamins, Biosensing Techniques

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Epidermal Enzymatic Biosensors for Sweat Vitamin C: Toward Personalized Nutrition

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