Cited by 97Nanoparticle-Based Drug DeliveryUltrasound and Hyperthermia ApplicationsAdvanced Drug Delivery Systems

Thermo-triggered Drug Release from Actively Targeting Polymer Micelles

Guo, Xing, Li, Dan, Yang, Guang, Shi, Chunli, Tang, Zhaomin, Wang, Jie, Zhou, Shaobing·2014·ACS Applied Materials & Interfaces

Abstract

How to deliver the drug to the target area at the right time and at the right concentration is still a challenge in cancer therapy. In this study, we present a facile strategy to control drug release by precisely controlling the thermo-sensitivity of the nanocarriers to the variation of environmental temperature. One type of thermoresponsive Pluronic F127-poly(d,l-lactic acid) (F127-PLA, abbreviated as FP) copolymer micelles was developed and decorated with folate (FA) for active targeting. FP100 micelles assembled from FP with PLA segment having polymerization degree of 100 had a low critical solution temperature of 39.2 °C close to body temperature. At 37 °C, little amount of encapsulated anticancer drug DOX is released from the FP100 micelles, while at a slightly elevated temperature (40 °C), the shrinkage of thermoresponsive segments causes a rapid release of DOX and instantly increases the drug concentration locally. The cytocompatibility analysis and cellular uptake efficiency were characterized with the fibroblast cell line NIH 3T3 and human cervix adenocarcinoma cell line HeLa. The results demonstrate that this copolymer has excellent cytocompatibility, and FA-decorated FP100 micelles present much better efficiency of cellular uptake and higher cytotoxicity to folate receptor (FR)-overexpressed HeLa cells. In particular, under hyperthermia (40 °C) the cytotoxicity of DOX-loaded FA-FP100 micelles against HeLa cells was significantly more obvious than that upon normothermia (37 °C). Therefore, these temperature-responsive micelles have great potential as a drug vehicle for cancer therapy.

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Crossref · 10.1021/am501422r

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  • Thermally responsive polymers are a key component of these systems, which are subjected to a distinctive volume phase transition to become hydrophobic or hydrophilic at different temperature.

    “Thermally responsive polymers are a key component of these systems, which are subjected to a distinctive volume phase transition to become hydrophobic or hydrophilic at different temperature.171”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [171]

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Authors
Guo, X., Li, D., Yang, G., Shi, C., Tang, Z., Wang, J., & Zhou, S.
Affiliations
Southwest Jiaotong University (CN)
Corresponding author
Zhou, Shaobing
Venue
ACS Applied Materials & Interfaces
Published
2014-05-07
Volume
6
Issue
11
Pages
8549-8559
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W2319121321
Cited by
97
References
43
Citations by year
2026: 4 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 13 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 5 · 2014: 1
FWCI
3.91
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
Pluronic F127, poly(D,L-lactide), folate targeting, drug release, doxorubicin, hyperthermia, folate receptor, anticancer drug delivery, critical solution temperature, cytocompatibility, cellular uptake, HeLa cells
MeSH terms
Animals, Doxorubicin, Drug Carriers, HeLa Cells, Humans, Micelles, Polymers, NIH 3T3 Cells, Mice

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