Total Synthesis of the Antimalarial Sesquiterpene Peroxide Qinghaosu and Yingzhaosu A
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ADVERTISEMENT RETURN TO ISSUEPREVArticleTotal Synthesis of the Antimalarial Sesquiterpene Peroxide Qinghaosu and Yingzhaosu AWei-Shan Zhou and Xing-Xiang XuCite this: Acc. Chem. Res. 1994, 27, 7, 211–216Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/ar00043a005https://doi.org/10.1021/ar00043a005research-articleACS PublicationsRequest reuse permissionsArticle Views1522Altmetric-Citations146LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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Chemical synthesis of artemisinin is far too expensive for many in the Third World because of the structural complexity of the target and the large number of steps in published synthetic routes.
“Although artemisinin can be produced by chemical synthesis [171,228,229,230,231,232,233,234,235,236,237,238,239], the structural complexity of this target and the large number of steps involved in all published synthetic routes render this approach far too expensive for many in the Third World who are most affected by malaria.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [234]
Cites
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Arteether, a new antimalarial drug: synthesis and antimalarial properties
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Total synthesis of arteannuin and deoxyarteannuin
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Stereoselective synthesis of artemisinin
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Synthesis and antimalarial activity of (+)-deoxoartemisinin
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A total synthesis of the antimarial natural product (+)-qinghaosu
Hsing-Jang, L., Wen-Lung, Y., & Sew, Y. C. (1993) · Tetrahedron Letters · doi:10.1016/0040-4039(93)88052-k · Cited by 78 · see citing works
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Total synthesis of (+)-Yingzhaosu A
Xu, X., Zhu, J., Da-Zhong, H., & Zhou, W. (1991) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)93555-x · Cited by 46 · see citing works
Self-citationAn efficient partial synthesis of (+)-artemisinin and (+)-deoxoartemisinin
Lansbury, P. T., & Nowak, D. M. (1992) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)91851-3 · Cited by 42 · see citing works
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
The mechanism of the spontaneous autoxidation of dihydroartemisinic acid
Sy, L.-K., & Brown, G. D. (2002) · Tetrahedron · doi:10.1016/s0040-4020(01)01193-0 · Cited by 129 · see citing works
The role of the 12-carboxylic acid group in the spontaneous autoxidation of dihydroartemisinic acid
Sy, L.-K., & Brown, G. D. (2002) · Tetrahedron · doi:10.1016/s0040-4020(01)01192-9 · Cited by 36 · see citing works
Synthesis of 6,7-dehydroartemisinic acid
Sy, L.-K., & Brown, G. D. (2001) · Journal of the Chemical Society, Perkin Transactions 1 · doi:10.1039/b104471k · Cited by 19 · see citing works
- Authors
- Zhou, W.-S., & Xu, X.-X.
- Venue
- Accounts of Chemical Research
- Publisher
- American Chemical Society (ACS)
- Published
- 1994-07-01
- Volume
- 27
- Issue
- 7
- Pages
- 211-216
- ISSN
- 0001-4842 (ISSN-L)
- 1520-4898
- OpenAlex
- W2168360270
- Cited by
- 147
- References
- 12
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Accounts of Chemical Research (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- total synthesis, artemisinin, artemisinin derivatives, antimalarial drugs, sesquiterpenes
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