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Cited by 316

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Evolution of Dynamic Combinatorial Chemistry

Cougnon, Fabien B. L., Sanders, Jeremy K. M.·2012·Accounts of Chemical Research
DOI 10.1021/ar200240m
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Abstract

Since its inception in the mid-1990s, dynamic combinatorial chemistry (DCC), the chemistry of complex systems under thermodynamic control, has proved valuable in identifying unexpected molecules with remarkable binding properties and in providing effective synthetic routes to complex species. Essentially, in this approach, one designs the experiment rather than the molecule. DCC has also provided us with insights into how some chemical systems respond to external stimuli. Using examples from the work of our laboratory and others, this Account shows how the concept of DCC, inspired by the evolution of living systems, has found an increasing range of applications in diverse areas and has evolved conceptually and experimentally. A dynamic combinatorial library (DCL) is a thermodynamically controlled mixture of interconverting species that can respond to various stimuli. The Cambridge version of dynamic combinatorial chemistry was initially inspired by the mammalian immune system and was conceived as a way to create and identify new unpredictable receptors. For example, an added template can select and stabilize a strongly binding member of the library which is then amplified at the expense of the unsuccessful library members, minimizing the free energy of the system. But researchers have exploited DCC in a variety of other ways: over the past two decades, this technique has contributed to the evolution of chemistry and to applications in the diverse fields of catalysis, fragrance release, and responsive materials. Among these applications, researchers have built intricate and well-defined architectures such as catenanes or hydrogen-bonded nanotubes, using the ability of complex chemical systems to reach a high level of organization. In addition, DCC has proved a powerful tool for the study of complex molecular networks and systems. The use of DCC is improving our understanding of chemical and biological systems. The study of folding or self-replicating macrocycles in DCLs has served as a model for appreciating how complex organisations such as life can emerge from a pool of simple chemicals. Today, DCC is no longer restricted to thermodynamic control, and new systems have recently appeared in which kinetic and thermodynamic control coexist. Expanding the realm of DCC to unexplored and promising new territories, these hybrid systems show that the concept of dynamic combinatorial chemistry continues to evolve.

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Metadata

Authors
Cougnon, F. B. L., & Sanders, J. K. M.
Venue
Accounts of Chemical Research
Publisher
American Chemical Society (ACS)
Published
2011-12-29
Volume
45
Issue
12
Pages
2211-2221
ISSN
  • 0001-4842 (ISSN-L)
  • 1520-4898
DOI
10.1021/ar200240m
OpenAlex
W2319763534
Cited by
316
References
36
FWCI
12.42
Type
journal article
Language
en
Open access
closed

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