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Transferrin-Mediated Gold Nanoparticle Cellular Uptake
Abstract
Targeted drug delivery is an important research area in specific therapy. Transferrin-conjugated nanoparticles are an attractive formulation as a vehicle for specific cellular uptake and targeted drug delivery. In this report, atomic force microscopy imaging was used to visualize the process of cellular uptake of transferrin-coupled gold nanoparticles on the surfaces of live cells for the first time. High-resolution images were captured, showing the endocytosis of transferrin-conjugated nanoparticles taking place during the process of internalization. This specific transferrin-mediated nanoparticle uptake was validated by confocal scanning imaging and transferrin competition experiments.
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Cited by
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Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998
Cho, E. C., Xie, J., Wurm, P. A., & Xia, Y. (2009) · Nano Letters · doi:10.1021/nl803487r · Cited by 819
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Kinetics of gold nanoparticles in the human placenta
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Metadata
- Authors
- Yang, P.-H., Sun, X., Chiu, J.-F., Sun, H., & He, Q.-Y.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-04-12
- Volume
- 16
- Issue
- 3
- Pages
- 494-496
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2043590679
- Cited by
- 295
- References
- 0
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
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