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Cited by 484

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Folate-Conjugated Iron Oxide Nanoparticles for Solid Tumor Targeting as Potential Specific Magnetic Hyperthermia Mediators: Synthesis, Physicochemical Characterization, and in Vitro Experiments

Sonvico, Fabio, Mornet, Stéphane, Vasseur, Sébastien, Dubernet, Catherine, Jaillard, Danielle, Degrouard, Jeril, Hoebeke, Johan, Duguet, Etienne, Colombo, Paolo, Couvreur, Patrick·2005·Bioconjugate Chemistry
DOI 10.1021/bc050050z
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Abstract

New folate-conjugated superparamagnetic maghemite nanoparticles have been synthesized for the intracellular hyperthermia treatment of solid tumors. These ultradispersed nanosystems have been characterized for their physicochemical properties and tumor cell targeting ability, facilitated by surface modification with folic acid. Preliminary experiments of nanoparticles heating under the influence of an alternating magnetic field at 108 kHz have been also performed. The nanoparticle size, surface charge, and colloidal stability have been assessed in various conditions of ionic strength and pH. The ability of these folate "decorated" maghemite nanoparticles to recognize the folate receptor has been investigated both by surface plasmon resonance and in folate receptor expressing cell lines, using radiolabeled folic acid in competitive binding experiments. The specificity of nanoparticle cellular uptake has been further investigated by transmission electron microscopy after incubation of these nanoparticles in the presence of three cell lines with differing folate receptor expression levels. Qualitative and quantitative determinations of both folate nanoparticles and nontargeted control nanoparticles demonstrated a specific cell internalization of the folate superparamagnetic nanoparticles.

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Crossref · 10.1021/bc050050z

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Metadata

Authors
Sonvico, F., Mornet, S., Vasseur, S., Dubernet, C., Jaillard, D., Degrouard, J., Hoebeke, J., Duguet, E., Colombo, P., & Couvreur, P.
Venue
Bioconjugate Chemistry
Publisher
American Chemical Society (ACS)
Published
2005-09-01
Volume
16
Issue
5
Pages
1181-1188
ISSN
  • 1043-1802 (ISSN-L)
  • 1520-4812
DOI
10.1021/bc050050z
OpenAlex
W2025565789
Cited by
484
References
31
FWCI
11.09
Type
journal article
Language
en
Open access
closed

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