The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Cellular Uptake Mechanism of an Inorganic Nanovehicle and Its Drug Conjugates: Enhanced Efficacy Due To Clathrin-Mediated Endocytosis
Abstract
We present the mechanism for the cellular uptake of layered double hydroxide (LDH) nanoparticles that are internalized into MNNG/HOS cells principally via clathrin-mediated endocytosis. The intracellular LDHs are highly colocalized with not only typical endocytic proteins, such as clathrin heavy chain, dynamin, and eps15, but also transferrin, a marker of the clathrin-mediated process, suggesting their specific internalization pathway. LDHs loaded with an anticancer drug (MTX-LDH) were also prepared to confirm the efficacy of LDHs as drug delivery systems. The cellular uptake of MTX was higher in MTX-LDH-treated cells than in MTX-treated cells, giving a lower IC50 value for MTX-LDH than for MTX only. The inhibition of the cell cycle was greater for MTX-LDH than for MTX only. This result clearly shows that the internalization of LDH nanoparticles via clathrin-mediated endocytosis may allow the efficient delivery of MTX-LDH in cells and thus enhance drug efficacy.
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1 retracted
A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells
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Carbon Nanotubes as Intracellular Protein Transporters: Generality and Biological Functionality
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Cited by
Harush-Frenkel, O., Rozentur, E., Benita, S., & Altschuler, Y. (2008) · Biomacromolecules · doi:10.1021/bm700535p · Cited by 405
Hybrid materials based on clays for environmental and biomedical applications
Ruiz-Hitzky, E., Aranda, P., Darder, M., & Rytwo, G. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00432d · Cited by 325
Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles
Li, L., Gu, W., Chen, J., Chen, W., & Xu, Z. P. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.095 · Cited by 304
Cui, C., Xue, Y.-N., Wu, M., Zhang, Y., Yu, P., Liu, L., Zhuo, R.-X., & Huang, S.-W. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.101 · Cited by 169
Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity
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Metadata
- Authors
- Oh, J.-M., Choi, S.-J., Kim, S.-T., & Choy, J.-H.
- Venue
- Bioconjugate Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-10-21
- Volume
- 17
- Issue
- 6
- Pages
- 1411-1417
- ISSN
- 1043-1802 (ISSN-L)
- 1520-4812
- OpenAlex
- W2016637754
- Cited by
- 254
- References
- 29
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
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