Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism

Enzyme structure and mechanism

Fersht, A. (1977) · Medical Entomology and Zoology · Cited by 2,875

Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

Milligan, J. F., Groebe, D. R., Witherell, G. W., & Uhlenbeck, O. C. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.21.8783 · Cited by 2,136

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

Beese, L. S., & Steitz, T. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07917.x · Cited by 1,048

Reaction mechanism of alkaline phosphatase based on crystal structures

Kim, E. E., & Wyckoff, H. W. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90724-k · Cited by 944

A small catalytic oligoribonucleotide

Uhlenbeck, O. C. (1987) · Nature · doi:10.1038/328596a0 · Cited by 930

Autolytic Processing of Dimeric Plant Virus Satellite RNA

Prody, G. A., Bakos, J. T., Buzayan, J. M., Schneider, I. R., & Bruening, G. (1986) · Science · doi:10.1126/science.231.4745.1577 · Cited by 632

Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroid

Hutchins, C. J., Rathjen, P. D., Forster, A. C., & Symons, R. H. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.9.3627 · Cited by 585

3′-Terminal labelling of RNA with T4 RNA ligase

ENGLAND, T. E., & UHLENBECK, O. C. (1978) · Nature · doi:10.1038/275560a0 · Cited by 555

Sequence requirements of the hammerhead RNA self-cleavage reaction

Ruffner, D. E., Stormo, G. D., & Uhlenbeck, O. C. (1990) · Biochemistry · doi:10.1021/bi00499a018 · Cited by 470

High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus

Hough, E., Hansen, L. K., Birknes, B., Jynge, K., Hansen, S., Hordvik, A., Little, C., Dodson, E., & Derewenda, Z. (1989) · Nature · doi:10.1038/338357a0 · Cited by 455

The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA

Usman, N., Ogilvie, K. K., Jiang, M. Y., & Cedergren, R. J. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00259a037 · Cited by 366

Role of divalent metal ions in the hammerhead RNA cleavage reaction

Dahm, S. C., & Uhlenbeck, O. C. (1991) · Biochemistry · doi:10.1021/bi00103a011 · Cited by 366

Visualizing the Higher Order Folding of a Catalytic RNA Molecule

Celander, D. W., & Cech, T. R. (1991) · Science · doi:10.1126/science.1989074 · Cited by 352

A crystallographic study of metal-binding to yeast phenylalanine transfer RNA

Jack, A., Landner, J. E., Rhodes, D., Brown, R. S., & Klug, A. (1977) · Journal of Molecular Biology · doi:10.1016/s0022-2836(77)80054-5 · Cited by 321

The Metallobiochemistry of Zinc Enzymes

Vallee, B. L., & Galdes, A. (1984) · Advances in Enzymology - and Related Areas of Molecular Biology · doi:10.1002/9780470123027.ch5 · Cited by 310

Atlas of metal—ligand equilibria in aqueous solution

Kragten, J. (1979) · Electrochimica Acta · doi:10.1016/0013-4686(79)87059-0 · Cited by 296

The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reaction.

Derbyshire, V., Grindley, N. D., & Joyce, C. M. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07916.x · Cited by 272

Crystallographic and biochemical investigation of the lead(II)-catalyzed hydrolysis of yeast phenylalanine tRNA

Brown, R. S., Dewan, J. C., & Klug, A. (1985) · Biochemistry · doi:10.1021/bi00339a012 · Cited by 262

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

Slim, G., & Gait, M. J. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.6.1183 · Cited by 246

Substrate sequence effects on "hammerhead" RNA catalytic efficiency.

Fedor, M. J., & Uhlenbeck, O. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1668 · Cited by 233

Pb(II)-catalysed cleavage of the sugar–phosphate backbone of yeast tRNAPhe—implications for lead toxicity and self-splicing RNA

Brown, R. S., Hingerty, B. E., Dewan, J. C., & Klug, A. (1983) · Nature · doi:10.1038/303543a0 · Cited by 226

Kinetics of intermolecular cleavage by hammerhead ribozymes

Fedor, M. J., & Uhlenbeck, O. C. (1992) · Biochemistry · doi:10.1021/bi00163a012 · Cited by 202

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and magnesium binding

Koizumi, M., & Ohtsuka, E. (1991) · Biochemistry · doi:10.1021/bi00235a005 · Cited by 181

Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration

van Tol, H., Buzayan, J. M., Feldstein, P. A., Eckstein, F., & Bruening, G. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.8.1971 · Cited by 172

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

Perreault, J.-P., Wu, T., Cousineau, B., Ogilvie, K. K., & Cedergren, R. (1990) · Nature · doi:10.1038/344565a0 · Cited by 169

Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction

Ruffner, D. E., & Uhlenbeck, O. C. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.20.6025 · Cited by 161

Lead-catalyzed cleavage of yeast tRNAPhe mutants

Behlen, L. S., Sampson, J. R., DiRenzo, A. B., & Uhlenbeck, O. C. (1990) · Biochemistry · doi:10.1021/bi00462a013 · Cited by 155

Nuclease resistant ribozymes with high catalytic activity.

Paolella, G., Sproat, B. S., & Lamond, A. I. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05244.x · Cited by 146

The effect of divalent metal ions on the rate and transition-state structure of phosphoryl-transfer reactions

Herschlag, D., & Jencks, W. P. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00249a033 · Cited by 133

Design of RNA enzymes distinguishing a single base mutation in RNA

Koizumi, M., Hayase, Y., Iwai, S., Kamiya, H., Inoue, H., & Ohtsuka, E. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.17.7059 · Cited by 125

Calcium(II) site specificity: effect of size and charge on metal ion binding to an EF-hand-like site

Snyder, E. E., Buoscio, B. W., & Falke, J. J. (1990) · Biochemistry · doi:10.1021/bi00468a021 · Cited by 123

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis

Perreault, J., Labuda, D., Usman, N., Yang, J. H., & Cedergren, R. (1991) · Biochemistry · doi:10.1021/bi00230a029 · Cited by 121

Cleavage of specific sites of RNA by designed ribozymes

Koizumi, M., Iwai, S., & Ohtsuka, E. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80935-9 · Cited by 113

Metal ions in genetic information transfer

Eichhorn, G. L., Marzilli, L. G., & Marzilli, P. A. (1981) · Elsevier eBooks · Cited by 98

Two histidine residues are essential for ribonuclease T1 activity as is the case for ribonuclease A

Nishikawa, S., Morioka, H., Kim, H. J., Fuchimura, K., Tanaka, T., Uesugi, S., Hakoshima, T., Tomita, K., Ohtsuka, E., & Ikehara, M. (1987) · Biochemistry · doi:10.1021/bi00400a019 · Cited by 97

Mutagenesis analysis of a self-cleaving RNA

Sheldon, C. C., & Symons, R. H. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.14.5679 · Cited by 90

Studies on the hammerhead RNA self-cleaving domain

Ruffner, D. E., Dahm, S. C., & Uhlenbeck, O. C. (1989) · Gene · doi:10.1016/0378-1119(89)90027-9 · Cited by 80

Structure primaire des tRNA

Dirheimer, G., Ebel, J., Bonnet, J., Gangloff, J., Keith, G., Krebs, B., Kuntzel, B., Roy, A. K., Weissenbach, J., & Werner, C. (1972) · Biochimie · doi:10.1016/s0300-9084(72)80097-x · Cited by 72

Energetics of RNA cleavage: implications for the mechanism of action of ribozymes

Taira, K., Uebayasi, M., Maeda, H., & Furukawa, K. (1990) · Protein Engineering Design and Selection · doi:10.1093/protein/3.8.691 · Cited by 37

Characterization of deoxy- and ribo-containing oligonucleotide substrates in the hammerhead self-cleavage reaction

Dahm, S. C., & Uhlenbeck, O. C. (1990) · Biochimie · doi:10.1016/0300-9084(90)90191-i · Cited by 31

Nonenzymatic hydrolysis of RNA: Pb(II)-catalyzed site specific hydrolysis of transfer RNA. The role of the tertiary folding of the polynucleotide chain

Sundaralingam, M., Rubin, J. R., & Cannon, J. F. (1984) · International Journal of Quantum Chemistry · doi:10.1002/qua.560260736 · Cited by 23

A general purpose RNA-cleaving DNA enzyme

Santoro, S. W., & Joyce, G. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4262 · Cited by 1,541

Three-dimensional structure of a hammerhead ribozyme

Pley, H. W., Flaherty, K. M., & McKay, D. B. (1994) · Nature · doi:10.1038/372068a0 · Cited by 953

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

Scott, W. G., Finch, J. T., & Klug, A. (1995) · Cell · doi:10.1016/s0092-8674(05)80004-2 · Cited by 685

A DNA enzyme with Mg2+-dependent RNA phosphoesterase activity

Breaker, R. R., & Joyce, G. F. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90028-4 · Cited by 420

General Acid-Base Catalysis in the Mechanism of a Hepatitis Delta Virus Ribozyme

Nakano, S.-I., Chadalavada, D. M., & Bevilacqua, P. C. (2000) · Science · doi:10.1126/science.287.5457.1493 · Cited by 385