Interaction of the N-Terminal Domain of Apolipoprotein E4 with Heparin

The Metabolic and Molecular Bases of Inherited Disease

Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101 · see citing works

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

Brünger, A. T. (1992) · Medical Entomology and Zoology · Cited by 3,439 · see citing works

Molecular modeling of protein-glycosaminoglycan interactions.

Cardin, A. D., & Weintraub, H. J. R. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.1.21 · Cited by 1,301 · see citing works

A visual protein crystallographic software system for X11/Xview

McRee, D. E. (1992) · Journal of Molecular Graphics · doi:10.1016/0263-7855(92)80022-6 · Cited by 550 · see citing works

N.m.r. and molecular-modelling studies of the solution conformation of heparin

Mulloy, B., Forster, M. J., Jones, C., & Davies, D. B. (1993) · Biochemical Journal · doi:10.1042/bj2930849 · Cited by 410 · see citing works

Human apolipoprotein E: the Alzheimer's disease connection

Weisgraber, K. H., & Mahley, R. W. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.13.8940294 · Cited by 327 · see citing works

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

Wetterau, J. R., Aggerbeck, L. P., Rall, S. C., & Weisgraber, K. H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68778-2 · Cited by 293 · see citing works

Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.

Weisgraber, K. H., Rall, S. C., Mahley, R. W., Milne, R. W., Marcel, Y. L., & Sparrow, J. T. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35898-2 · Cited by 240 · see citing works

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

Aggerbeck, L. P., Wetterau, J. R., Weisgraber, K. H., Wu, C. S., & Lindgren, F. T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68779-4 · Cited by 229 · see citing works

Apolipoprotein E and atherosclerosis: insight from animal and human studies

Davignon, J., Cohn, J. S., Mabile, L., & Bernier, L. (1999) · Clinica Chimica Acta · doi:10.1016/s0009-8981(99)00097-2 · Cited by 208 · see citing works

Preparation and structural characterization of large heparin-derived oligosaccharides

Pervin, A., Gallo, C. M., Jandik, K. A., Han, X.-J., & Linhardt, R. J. (1995) · Glycobiology · doi:10.1093/glycob/5.1.83 · Cited by 202 · see citing works

Mechanism of Heparin Activation of Antithrombin

Desai, U. R., Petitou, M., Björk, I., & Olson, S. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7478 · Cited by 190 · see citing works

NMR solution conformation of heparin-derived hexasaccharide

Mikhailov, D., LINHARDT, J. R., & MAYO, H. K. (1997) · Biochemical Journal · doi:10.1042/bj3280051 · Cited by 98 · see citing works

Structure of heparin-derived tetrasaccharides

Merchant, Z. M., Kim, Y. S., Rice, K. G., & Linhardt, R. J. (1985) · Biochemical Journal · doi:10.1042/bj2290369 · Cited by 95 · see citing works

The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia

Horie, Y., Fazio, S., Westerlund, J. R., Weisgraber, K. H., & Rall, S. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46040-1 · Cited by 94 · see citing works

Carbohydrates as Drugs

Seeberger, P. H., & Rademacher, C. (2014) · Topics in medicinal chemistry · doi:10.1007/978-3-319-08675-0 · Cited by 62 · see citing works

Interaction of heparin with annexin V

Capila, I., VanderNoot, V. A., Mealy, T. R., Seaton, B. A., & Linhardt, R. J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00245-8 · Cited by 55 · see citing works

Sculpt: interactive manipulation of proteins while modeling atomic forces

Surles, M. C. (1992) · Journal of Molecular Graphics · doi:10.1016/0263-7855(92)80023-7 · Cited by 39 · see citing works

Kinetics of apolipoprotein E isoforms‐binding to the major glycosaminoglycans of the extracellular matrix

Shuvaev, V. V., Laffont, I., & Siest, G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01285-5 · Cited by 27 · see citing works

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C.-C., & Bu, G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0228-7 · Cited by 1,425 · see citing works

Survey of the year 2003 commercial optical biosensor literature

Rich, R. L., & Myszka, D. G. (2004) · Journal of Molecular Recognition · doi:10.1002/jmr.726 · Cited by 505 · see citing works

2003 Claude S. Hudson Award Address in Carbohydrate Chemistry. Heparin: Structure and Activity

Linhardt, R. J. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm030176m · Cited by 493 · see citing works

A model for non‐viral gene delivery: through syndecan adhesion molecules and powered by actin

Kopatz, I., Rémy, J.-S., & Behr, J. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.558 · Cited by 324 · see citing works

Role of Glycosaminoglycans in Cellular Communication

Linhardt, R. J., & Toida, T. (2004) · Accounts of Chemical Research · doi:10.1021/ar030138x · Cited by 299 · see citing works

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.008 · Cited by 298 · see citing works

Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and experimental approaches

Powell, A. K. (2004) · Glycobiology · doi:10.1093/glycob/cwh051 · Cited by 257 · see citing works

Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice

Stanford, K. I., Bishop, J. R., Foley, E. M., Gonzales, J. C., Niesman, I. R., Witztum, J. L., & Esko, J. D. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38251 · Cited by 226 · see citing works

Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members

MacArthur, J. M., Bishop, J. R., Stanford, K. I., Wang, L., Bensadoun, A., Witztum, J. L., & Esko, J. D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29154 · Cited by 216 · see citing works

Role of glycosaminoglycans for binding and infection of hepatitis B virus

Leistner, C. M., Grün, S., & Glebe, D. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01023.x · Cited by 192 · see citing works

Chemical approaches to deciphering the glycosaminoglycan code

Gama, C. I., & Hsieh‐Wilson, L. C. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.10.003 · Cited by 139 · see citing works

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer’s disease

Frieden, C., & Garai, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207022109 · Cited by 133 · see citing works

Direct Evidence for the Nonrandom Nature of Al Substitution in Zeolite ZSM-5: An Investigation by27Al MAS and MQ MAS NMR

Han, O. H., Kim, C.-S., & Hong, S. B. (2002) · Angewandte Chemie · doi:10.1002/1521-3757(20020201)114:3 · Cited by 20 · see citing works

New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E

Libeu, C. P., Lund-Katz, S., Phillips, M. C., Wehrli, S., Hernáiz, M. J., Capila, I., Linhardt, R. J., Raffaı̈, R. L., Newhouse, Y. M., Zhou, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104746200 · Cited by 113 · see citing works

Apolipoprotein A-V Interaction with Members of the Low Density Lipoprotein Receptor Gene Family

Nilsson, S. K., Lõokene, A., Beckstead, J. A., Gliemann, J., Ryan, R. O., & Olivecrona, G. (2007) · Biochemistry · doi:10.1021/bi7000533 · Cited by 102 · see citing works

Survey of the year 2001 commercial optical biosensor literature

Rich, R. L., & Myszka, D. G. (2002) · Journal of Molecular Recognition · doi:10.1002/jmr.598 · Cited by 99 · see citing works

The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway

Jendresen, C., Årskog, V., Daws, M. R., & Nilsson, L. N. G. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0835-4 · Cited by 94 · see citing works

Two-step Mechanism of Binding of Apolipoprotein E to Heparin

Futamura, M., Dhanasekaran, P., Handa, T., Phillips, M. C., Lund-Katz, S., & Saito, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411719200 · Cited by 91 · see citing works

Characterization of the Heparin Binding Sites in Human Apolipoprotein E

Saito, H., Dhanasekaran, P., Nguyen, D., Baldwin, F., Weisgraber, K. H., Wehrli, S., Phillips, M. C., & Lund-Katz, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213207200 · Cited by 90 · see citing works

Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis

Prince, S. M., Achtman, M., & Derrick, J. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062630899 · Cited by 89 · see citing works

Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization

Huang, R. Y.-C., Garai, K., Frieden, C., & Gross, M. L. (2011) · Biochemistry · doi:10.1021/bi2010027 · Cited by 97 · see citing works

Spectroscopic Studies of GSK3β Phosphorylation of the Neuronal Tau Protein and Its Interaction with the N-Terminal Domain of Apolipoprotein E

Leroy, A., Landrieu, I., Huvent, I., Legrand, D., Codeville, B., Wieruszeski, J.-M., & Lippens, G. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149419 · Cited by 86 · see citing works

Heparan Sulfate 2-O-Sulfotransferase Is Required for Triglyceride-rich Lipoprotein Clearance

Stanford, K. I., Wang, L., Castagnola, J., Song, D., Bishop, J. R., Brown, J. R., Lawrence, R., Bai, X., Habuchi, H., Tanaka, M., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.063701 · Cited by 84 · see citing works

Molecular biology of apolipoprotein E

Strittmatter, W. J., & Hill, C. B. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00002 · Cited by 80 · see citing works

Mosquito Heparan Sulfate and Its Potential Role in Malaria Infection and Transmission

Sinnis, P., Coppi, A., Toida, T., Toyoda, H., Kinoshita‐Toyoda, A., Xie, J., Kemp, M. M., & Linhardt, R. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704698200 · Cited by 76 · see citing works

Unbiased Identification of the Liposome Protein Corona using Photoaffinity-based Chemoproteomics

Pattipeiluhu, R., Crielaard, S., Klein-Schiphorst, I., Florea, B. I., Kros, A., & Campbell, F. (2020) · ACS Central Science · doi:10.1021/acscentsci.9b01222 · Cited by 74 · see citing works

Structural characterization of human liver heparan sulfate

Vongchan, P., Warda, M., Toyoda, H., Toida, T., Marks, R. M., & Linhardt, R. J. (2004) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2004.09.007 · Cited by 73 · see citing works

Mechanistic and therapeutic overview of glycosaminoglycans: the unsung heroes of biomolecular signaling

Gulati, K., & Poluri, K. M. (2015) · Glycoconjugate Journal · doi:10.1007/s10719-015-9642-2 · Cited by 70 · see citing works

Heparan sulfate promotes the aggregation of HDL‐associated serum amyloid A: evidence for a proamyloidogenic histidine molecular switch

Elimova, E., Kisilevsky, R., & Ancsin, J. B. (2009) · The FASEB Journal · doi:10.1096/fj.09-134981 · Cited by 59 · see citing works

Role of the N- and C-Terminal Domains in Binding of Apolipoprotein E Isoforms to Heparan Sulfate and Dermatan Sulfate: A Surface Plasmon Resonance Study

Yamauchi, Y., Deguchi, N., Takagi, C., Tanaka, M., Dhanasekaran, P., Nakano, M., Handa, T., Phillips, M. C., Lund-Katz, S., & Saito, H. (2008) · Biochemistry · doi:10.1021/bi8003999 · Cited by 53 · see citing works

A Highly Stable Covalent Conjugated Heparin Biochip for Heparin–Protein Interaction Studies

Zhang, F., Fath, M. A., Marks, R. M., & Linhardt, R. J. (2002) · Analytical Biochemistry · doi:10.1006/abio.2002.5617 · Cited by 56 · see citing works

Surface plasmon resonance for the analysis of β-amyloid interactions and fibril formation in alzheimer’s disease research

Aguilar, M. I., & Small, D. H. (2005) · Neurotoxicity Research · doi:10.1007/bf03033773 · Cited by 54 · see citing works

Lipids Activate SecA for High Affinity Binding to the SecYEG Complex

Koch, S., de Wit, J. G., Vos, I., Birkner, J. P., Gordiichuk, P. I., Herrmann, A. P., van Oijen, A. M., & Driessen, A. J. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.743831 · Cited by 53 · see citing works

Heparan sulfate proteoglycans and triglyceride-rich lipoprotein metabolism

Bishop, J. R., Stanford, K. I., & Esko, J. D. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282feec2d · Cited by 52 · see citing works

A surface plasmon resonance-based solution affinity assay for heparan sulfate-binding proteins

Cochran, S., Li, C. P., & Ferro, V. (2008) · Glycoconjugate Journal · doi:10.1007/s10719-008-9210-0 · Cited by 50 · see citing works

Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms

Stuchell-Brereton, M. D., Zimmerman, M. I., Miller, J. J., Mallimadugula, U. L., Incicco, J. J., Roy, D., Smith, L. G., Cubuk, J., Baban, B., DeKoster, G. T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215371120 · Cited by 48 · see citing works

Binding Preferences for GPIHBP1, a Glycosylphosphatidylinositol-Anchored Protein of Capillary Endothelial Cells

Gin, P., Beigneux, A. P., Voss, C. V., Davies, B. S. J., Beckstead, J. A., Ryan, R. O., Bensadoun, A., Fong, L. G., & Young, S. G. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.214718 · Cited by 48 · see citing works

Alzheimer's Disease: Another Target for Heparin Therapy

Bergamaschini, L. C., Rossi, E., Vergani, C., & Simoni, M. G. D. (2009) · The Scientific World JOURNAL · doi:10.1100/tsw.2009.100 · Cited by 46 · see citing works

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

Raulin, A.-C., Kraft, L., Al-Hilaly, Y. K., Xue, W.-F., McGeehan, J. E., Atack, J. R., & Serpell, L. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.019 · Cited by 47 · see citing works

Novel Family of Insect Salivary Inhibitors Blocks Contact Pathway Activation by Binding to Polyphosphate, Heparin, and Dextran Sulfate

Alvarenga, P. H., Xu, X., Oliveira, F., Chagas, A. C., Nascimento, C. R., Francischetti, I. M. B., Juliano, M. A., Juliano, L., Scharfstein, J., Valenzuela, J. G., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302482 · Cited by 46 · see citing works

Hepatic Heparan Sulfate Proteoglycans and Endocytic Clearance of Triglyceride-Rich Lipoproteins

Foley, E. M., & Esko, J. D. (2010) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(10)93010-x · Cited by 45 · see citing works

Heparin: role in protein purification and substitution with animal-component free material

Bolten, S. N., Rinas, U., & Scheper, T. H. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9263-3 · Cited by 40 · see citing works

Cell surface adhesion of pregnancy‐associated plasma protein‐A is mediated by four clusters of basic residues located in its third and fourth CCP module

Weyer, K., Overgaard, M. T., Laursen, L. S., Nielsen, C. G., Schmitz, A., Christiansen, M., Sottrup‐Jensen, L., Giudice, L. C., & Oxvig, C. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04061.x · Cited by 38 · see citing works

Concerning the structure of apoE

Frieden, C., & Garai, K. (2013) · Protein Science · doi:10.1002/pro.2379 · Cited by 39 · see citing works

Poly(ethylene glycol)-based biosensor chip to study heparin–protein interactions

Munoz, E. M., Yu, H., Hallock, J., Edens, R. E., & Linhardt, R. J. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.04.031 · Cited by 34 · see citing works

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer

Petros, A. M., Korepanova, A., Jakob, C. G., Qiu, W., Panchal, S. C., Wang, J., Dietrich, J. D., Brewer, J. T., Pohlki, F., Kling, A., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00178 · Cited by 32 · see citing works

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Nemergut, M., Marques, S. M., Uhrik, L., Vanova, T., Nezvedova, M., Gadara, D. C., Jha, D., Tulis, J., Novakova, V., Planas-Iglesias, J., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00620-9 · Cited by 30 · see citing works

Apo<scp>E</scp>: The role of conserved residues in defining function

Frieden, C. (2015) · Protein Science · doi:10.1002/pro.2597 · Cited by 29 · see citing works

ApoE: In Vitro Studies of a Small Molecule Effector

Mondal, T., Wang, H., DeKoster, G. T., Baban, B. A., Gross, M. L., & Frieden, C. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00324 · Cited by 23 · see citing works

NKT Cells: The Culprits of Sepsis?

Leung, B., & Harris, H. W. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2010.09.038 · Cited by 23 · see citing works

Apolipoprotein E isoprotein-specific interactions with tissue plasminogen activator

Biehle, S. J., Carrozzella, J. A., Shukla, R., Popplewell, J. F., Swann, M. J., Freeman, N. J., & Clark, J. F. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.04.004 · Cited by 21 · see citing works

Capillary zone electrophoresis investigation of the interaction between heparin and granulocyte‐colony stimulating factor

Liang, A., He, X., Du, Y., Wang, K., Fung, Y., & Lin, B. (2004) · Electrophoresis · doi:10.1002/elps.200305728 · Cited by 21 · see citing works

Absence of apolipoprotein E protects mice from cerebral malaria

Kassa, F. A., Ham, K. V. D., Rainone, A., Fournier, S., Boilard, É., & Olivier, M. (2016) · Scientific Reports · doi:10.1038/srep33615 · Cited by 20 · see citing works

Characterization of heparin–protein interaction by saturation transfer difference (STD) NMR

Yu, F., Roy, S., Arevalo, E., Schaeck, J. J., Wang, J., Holte, K., Duffner, J. L., Günay, N. S., Capila, I., & Kaundinya, G. V. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-7729-4 · Cited by 19 · see citing works

Glycosaminoglycan–Protein Interaction Studies Using Fluorescence Spectroscopy

Boothello, R. S., Al‐Horani, R. A., & Desai, U. R. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1714-3_27 · Cited by 16 · see citing works

Conformational analysis, molecular structure, spectroscopic, NBO, reactivity descriptors, wavefunction and molecular docking investigations of 5,6-dimethoxy-1-indanone: A potential anti Alzheimer's agent

Sebastian, S. S. H. R., Sylvestre, S., Sundaraganesan, N., Karthikeyan, B., & Silvan, S. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e08821 · Cited by 16 · see citing works

Separation, identification, and interaction of heparin oligosaccharides with granulocyte-colony stimulating factor using capillary electrophoresis and mass spectrometry

Liang, A., Chao, Y., Liu, X., Du, Y., Wang, K., Qian, S., & Lin, B. (2005) · Electrophoresis · doi:10.1002/elps.200500115 · Cited by 16 · see citing works

Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants

Anower-E-Khuda, F., Singh, G., Deng, Y., Gordts, P. L. S. M., & Esko, J. D. (2019) · Glycobiology · doi:10.1093/glycob/cwz037 · Cited by 15 · see citing works

Capillary zone electrophoresis characterization of low molecular weight heparin binding to interleukin 2

Liang, A., He, X., Du, Y., Wang, K., Fung, Y., & Lin, B. (2005) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2005.01.019 · Cited by 15 · see citing works

Partial filling affinity capillary electrophoresis including adsorption energy distribution calculations – towards reliable and feasible biomolecular interaction studies

Witos, J., Samuelsson, J., Cilpa-Karhu, G., Metso, J., Jauhiainen, M., & Riekkola, M. (2015) · The Analyst · doi:10.1039/c5an00210a · Cited by 13 · see citing works

Nanolipoprotein Particles as a Delivery Platform for Fab Based Therapeutics

Darwish, M., Shatz-Binder, W., Leonard, B. C., Loyet, K. M., Barrett, K., Wong, J. L., Li, H., Abraham, R., Lin, M. H., Franke, Y., et al. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00349 · Cited by 13 · see citing works

Differences in Recycling of Apolipoprotein E3 and E4—LDL Receptor Complexes—A Mechanistic Hypothesis

Kim, M., & Борисович, Б. И. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095030 · Cited by 12 · see citing works

Glycosaminoglycans in Neurodegenerative Diseases

Jin, W., Zhang, F., & Linhardt, R. J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-70115-4_9 · Cited by 12 · see citing works

Dromedary glycosaminoglycans: Molecular characterization of camel lung and liver heparan sulfate

Warda, M., & Linhardt, R. J. (2005) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2005.09.015 · Cited by 12 · see citing works

The kinetics of polycyclic aromatic hydrocarbon (PAH) biodegradation assessed by isothermal titration calorimetry (ITC)

Buchholz, F., Wick, L. Y., Harms, H., & Maskow, T. (2007) · Thermochimica Acta · doi:10.1016/j.tca.2007.01.028 · Cited by 12 · see citing works

Heparin protects against septic mortality via apoE-antagonism

Chuang, K., Leung, B., Hsu, N. Y.-H., & Harris, H. W. (2011) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2010.10.017 · Cited by 10 · see citing works

Studies on the Effect of Calcium in Interactions Between Heparin and Heparin Cofactor II Using Surface Plasmon Resonance

Zhang, F., Wu, Y., Ma, Q., Hoppensteadt, D., Fareed, J., & Linhardt, R. J. (2004) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/107602960401000307 · Cited by 8 · see citing works

Further characterization of the binding of heparin to granulocyte colony‐stimulating factor: Importance of sulfate groups

Liang, A., Liu, X., Du, Y., Wang, K., & Lin, B. (2008) · Electrophoresis · doi:10.1002/elps.200700480 · Cited by 8 · see citing works

Next-Generation Sequencing of a Large Gene Panel for Outcome Prediction of Bariatric Surgery in Patients with Severe Obesity

Bonetti, G., Dhuli, K., Ceccarini, M. R., Kaftalli, J., Samaja, M., Precone, V., Cecchin, S., Maltese, P. E., Guerri, G., Marceddu, G., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11247531 · Cited by 7 · see citing works

Advances in Studying Glycosaminoglycan–Protein Interactions Using Capillary Electrophoresis

Liang, A., & Desai, U. R. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1398-6_30 · Cited by 7 · see citing works

In Silico Analysis of the Antagonist Effect of Enoxaparin on the ApoE4–Amyloid-Beta (Aβ) Complex at Different pH Conditions

Aguilar-Pineda, J. A., Paco-Coralla, S. G., Febres-Molina, C., Gamero-Begazo, P. L., Shrivastava, P., Vera-López, K. J., Dávila-Del-Carpio, G., López-Casaperalta, P., Gómez, B., & Cardenas, C. L. L. (2022) · Biomolecules · doi:10.3390/biom12040499 · Cited by 7 · see citing works

Biophysical Analysis of Sec-Mediated Protein Translocation in Nanodiscs

Koch, S., Driessen, A. J. M., & Kedrov, A. (2018) · Advances in biomembranes and lipid self-assembly · doi:10.1016/bs.abl.2018.05.003 · Cited by 6 · see citing works

Identification of a conformational heparin-recognition motif on the peptide hormone secretin: key role for cell surface binding

Quittot, N., Nguyen, P. T., Nerée, A. T., Lussier, M. P., & Bourgault, S. (2017) · Biochemical Journal · doi:10.1042/bcj20170035 · Cited by 6 · see citing works

Expression of human liver HSPGs on acute myeloid leukemia

Vongchan, P., & Linhardt, R. J. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.08.017 · Cited by 6 · see citing works

Inhibition of catechol-O-methyltransferase (COMT) by heparin oligosaccharides with specific structures

Chen, Q., Wang, Q., Bu, C., An, Z., Jin, L., & Chi, L. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.121909 · Cited by 5 · see citing works

Studying Glycosaminoglycan–Protein Interactions Using Capillary Electrophoresis

Liang, A., & Desai, U. R. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1714-3_28 · Cited by 4 · see citing works

Physiological, Pathophysiological and Therapeutic Roles of Heparin and Heparan Sulfate

Xie, J., Murugesan, S., & Linhardt, R. J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-08-054816-6.00010-0 · Cited by 4 · see citing works

Inhibition of human tumor xenograft growth in nude mice by a novel monoclonal anti-HSPG isolated from human liver.

Vongchan, P., Kothan, S., Wutti-In, Y., & Linhardt, R. J. (2011) · PubMed · Cited by 4 · see citing works

Mapping the APOE structurally on missense variants in elderly Brazilians

Pizzico, F. D. L., Máximo, R. B., Hirata, M. H., & Ferreira, G. M. (2024) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2024.2328743 · Cited by 3 · see citing works

Compilation and Analysis of Enzymes, Engineered Antibodies, and Nanoparticles Designed to Interfere with Amyloid‐β Aggregation

Zhao, J., Ma, B., & Nussinov, R. (2016) · Israel Journal of Chemistry · doi:10.1002/ijch.201600093 · Cited by 2 · see citing works

Glycation-induced conformational disruption in Apolipoprotein E3 impairs lipid and heparin binding functions: a molecular dynamics approach

Jeevanandam, J., & Saraswathi, N. T. (2025) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2025.2584338 · Cited by 1 · see citing works

Fractal Analysis of Binding and Dissociation of DNA–Analyte Interactions on Biosensor Surfaces

Sadana, A., & Sadana, N. (2008) · Elsevier eBooks · doi:10.1016/b978-044453010-3.50010-4 · Cited by 1 · see citing works

Proline Isomerization and Molten Globular Property of TgPDCD5 Secreted from Toxoplasma gondii Confers Its Regulation of Heparin Sulfate Binding

Lin, M.-H., Yu, T., Chang, C., & Hsu, C. (2024) · JACS Au · doi:10.1021/jacsau.3c00577 · Cited by 1 · see citing works

Domino-like Effect of C112R Mutation on ApoE4 Aggregation and Its Reduction by Alzheimer’s Disease Drug CandidatePreprint

Nemergut, M., Marques, S. M., Uhrík, L., Váňová, T., Nezvedová, M., Gadara, D. C., Jha, D., Tulis, J., Novakova, V., Planas-Iglesias, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.09.511473 · Cited by 1 · see citing works

Fractal Analysis of Heparin-Protein Interaction Studies Occurring on Biosensor Surfaces

Sadana, A. (2005) · Elsevier eBooks · doi:10.1016/b978-044451945-0/50010-8

Revealing host factors important for hepatocyte : infection by plasmodium

Rodrigues, C. D. (2007) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Preparation of Heparin Surface for Quantification of Fibroblast Growth Factor-2 (FGF-2) Binding Using Surface Plasmon Resonance (SPR).

Kirtland, D. R., Forsten‐Williams, K., Dessy, R. E., & Davis, R. M. (2005) · VTechWorks (Virginia Tech)

Thermodynamic Affinity and Nature of Forces Defining Glycosaminoglycan-Protein Systems Using Fluorescence Spectroscopy

Boothello, R. S., & Desai, U. R. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1398-6_21

Fractal Analysis of Binding and Dissociation of Protein–Analyte Interactions on Biosensor Surfaces

Sadana, A., & Sadana, N. (2008) · Elsevier eBooks · doi:10.1016/b978-044453010-3.50011-6

APOE and Oxidative Stress

Correas, Á. G., Stromsnes, K., Lupu, R. I., & González, G. O. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_29-1

Molecular dynamics of select missense mutations of Apolipoprotein E and their implications in Hyperlipoproteinemia type III

Thakur, S., Singh, B., & Singh, R. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102190

APOE Genotype Difference in the Biphasic Modulation of Amyloid-β Aggregation by Direct Binding and Lowering the Nucleation Barrier

Song, Z., Bhandari, K., Hou, T., & Ding, F. (2025) · Biomacromolecules · doi:10.1021/acs.biomac.5c01323

Additional file 3 of Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Nemergut, M., Marques, S. M., Uhrík, L., Váňová, T., Nezvedová, M., Gadara, D. C., Jha, D., Tulis, J., Novakova, V., Planas-Iglesias, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23304976

Additional file 1 of Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Nemergut, M., Marques, S. M., Uhrík, L., Váňová, T., Nezvedová, M., Gadara, D. C., Jha, D., Tulis, J., Novakova, V., Planas-Iglesias, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23304964

Additional file 2 of Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

Nemergut, M., Marques, S. M., Uhrík, L., Váňová, T., Nezvedová, M., Gadara, D. C., Jha, D., Tulis, J., Novakova, V., Planas-Iglesias, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23304970

Characterization of Hepatitis C Virus interaction with heparan sulfate proteoglycans

Xu, Y. (2014) · doi:10.70675/b8c9dc27z15cfz4921zad5czee757d47d341

Mass Spectrometry-Based Structural Proteomics and Analytical Ultracentrifugation Characterize the Structures of Oligomeric Apolipoprotein E4 and Its Variants

Yang, H.-C., DeKoster, G., Baban, B. A., Frieden, C., & Gross, M. L. (2026) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.6c00167

Physicochemical Insights into Apolipoprotein E Isoform-Dependent Inhibition of α-Synuclein Fibrillation

Namba, N., Ariyoshi, S., Shimba, A., Shiroshita, H., Ohgita, T., & Saito, H. (2026) · ACS Omega · doi:10.1021/acsomega.6c09295

Heparin-Protein Interactions

Capila, I., & Linhardt, R. J. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020201)41:3

Interaction of the N-terminal domain of apolipoprotein E4 with heparin, Biochemistry 40

Dong, J., Peters-libeu, C. A., Weisgraber, K. H., Segelke, B. W., Capila, I., Hernáiz, M. J., Lebrun, L. A., & Robert, J. (2001)

New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E*

Zhou, F., & Weisgraber, K. H. (2001)

Role of the N- and C-Terminal Domains in Binding of Apolipoprotein E Isoforms to Heparan Sulfate and Dermatan Sulfate: A Surface Plasmon Resonance Study

Yamauchi, Y., Deguchi, N., Takagi, C., Tanaka, M., Dhanasekaran, P., Nakano, M., Handa, T., Phillips, M. C., Lund-Katz, S., & Saito, H. (2008) · Biochemistry · doi:10.1021/bi8003999 · Cited by 53 · see citing works

Kinetics of apolipoprotein E isoforms‐binding to the major glycosaminoglycans of the extracellular matrix

Shuvaev, V. V., Laffont, I., & Siest, G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01285-5 · Cited by 27 · see citing works

Two-step Mechanism of Binding of Apolipoprotein E to Heparin

Futamura, M., Dhanasekaran, P., Handa, T., Phillips, M. C., Lund-Katz, S., & Saito, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411719200 · Cited by 91 · see citing works