The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
pH-Induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact
Abstract
The mechanism of pH-induced destabilization of liposomes composed of phosphatidylethanolamine and a charged cholesteryl ester was studied by following the release of encapsulated aqueous contents. The kinetics of release were measured continuously by using the water-soluble fluorophore 8-aminonaphthalene-1,3,6-trisulfonic acid in combination with the water-soluble quencher p- xylylenebis (pyridinium) bromide. With this fluorescence assay, release of contents from liposomes composed of phosphatidylethanolamine and cholesteryl hemisuccinate was shown to be a function of pH, ratio of phosphatidylethanolamine to cholesteryl hemisuccinate, and acyl chain composition of the phosphatidylethanolamine. Leakage was very slow at pH 5.5 and increased dramatically with decreasing pH down to 4.0. Replacing phosphatidylethanolamine by phosphatidylcholine eliminated the effect of pH on leakage. Analysis of the kinetics of release by a mass action model demonstrated that bilayer destabilization and leakage occur subsequent to aggregation. The requirement of bilayer contact for destabilization has been found previously for acidic phospholipid bilayers in the presence of divalent cation and for saturated phosphatidylcholine bilayers below the isothermal phase transition temperature. The phosphatidylethanolamine-containing bilayers examined here satisfy the same requirement.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Phosphorus Assay in Column Chromatography
Bartlett, G. R. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70226-3 · Cited by 12,801
Szoka, F., & Papahadjopoulos, D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4194 · Cited by 2,323
Self-citationLipid polymorphism and the functional roles of lipids in biological membranes
Cullis, P. R., & De Kruijff, B. (1979) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(79)90012-1 · Cited by 1,864
Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes
Olson, F., Hunt, C. A., Szoka, F. C., Vail, W. J., & Papahadjopoulos, D. (1979) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(79)90085-3 · Cited by 1,126
Self-citationLiposome-Cell Interaction: Transfer and Intracellular Release of a Trapped Fluorescent Marker
Weinstein, J. N., Yoshikami, S., Henkart, P., Blumenthal, R., & Hagins, W. A. (1977) · Science · doi:10.1126/science.835007 · Cited by 699
Wilschut, J., Duzgunes, N., Fraley, R., & Papahadjopoulos, D. (1980) · Biochemistry · doi:10.1021/bi00567a011 · Cited by 490
Portis, A., Newton, C., Pangborn, W., & Papahadjopoulos, D. (1979) · Biochemistry · doi:10.1021/bi00572a007 · Cited by 472
Serum-induced leakage of liposome contents
Allen, T. M., & Cleland, L. G. (1980) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(80)90118-2 · Cited by 468
Cullis, P. R., & De Kruijff, B. (1978) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(78)90109-8 · Cited by 426
CULLIS, P. R., & HOPE, M. J. (1978) · Nature · doi:10.1038/271672a0 · Cited by 305
Cited by
Andresen, T. L., Jensen, S. S., & Jørgensen, K. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.12.001 · Cited by 580
Biodegradable nanoparticles for cytosolic delivery of therapeutics
VASIR, J., & LABHASETWAR, V (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.06.003 · Cited by 526
Current status of pH-sensitive liposomes in drug delivery
Drummond, D. C., Zignani, M., & Leroux, J.-C. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00011-4 · Cited by 477
In vitro release kinetics model fitting of liposomes: An insight
Jain, A., & Jain, S. K. (2016) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2016.10.005 · Cited by 373
Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
Zgurskaya, H. I., & Nikaido, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7190 · Cited by 360
Metadata
- Authors
- Ellens, H., Bentz, J., & Szoka, F. C.
- Venue
- Biochemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1984-03-27
- Volume
- 23
- Issue
- 7
- Pages
- 1532-1538
- ISSN
- 0006-2960 (ISSN-L)
- 1520-4995
- OpenAlex
- W1964671048
- Cited by
- 440
- References
- 22
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: pH-Induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. https://app.cochat.ai/papers/10.1021/bi00302a029
- The paper
- Ellens, H., Bentz, J., & Szoka, F. C. (1984). pH-Induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry. https://doi.org/10.1021/bi00302a029
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
