The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.
Open accessAbstract
Large unilamellar and oligolamellar vesicles are formed when an aqueous buffer is introduced into a mixture of phospholipid and organic solvent and the organic solvent is subsequently removed by evaporation under reduced pressure. These vesicles can be made from various lipids or mixtures of lipids and have aqueous volume to lipid ratios that are 30 times higher than sonicated preparations and 4 times higher than multilamellar vesicles. Most importantly, a substantial fraction of the aqueous phase (up to 62% at low salt concentrations) is entrapped within the vesicles, encapsulating even large macromolecular assemblies with high efficiency. Thus, this relatively simple technique has unique advantages for encapsulating valuable water-soluble materials such as drugs, proteins, nucleic acids, and other biochemical reagents. The preparation and properties of the vesicles are described in detail.
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Cites
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664
Cited by
Liposomal drug delivery systems: From concept to clinical applications
Allen, T. M., & Cullis, P. R. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.037 · Cited by 4,839
Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221
New developments in liposomal drug delivery
Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600
Liposomes: Structure, composition, types, and clinical applications
Nsairat, H., Khater, D., Sayed, U., Odeh, F., Al Bawab, A., & Alshaer, W. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09394 · Cited by 1,561
Essential oils: From extraction to encapsulation
Asbahani, A. E., Miladi, K., Badri, W., Sala, M., Addi, E. H. A., Casabianca, H., Mousadik, A. E., Hartmann, D., Jilale, A., Renaud, F. N. R., et al. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.12.069 · Cited by 1,065
Metadata
- Authors
- Szoka, F., & Papahadjopoulos, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1978-09
- Volume
- 75
- Issue
- 9
- Pages
- 4194-4198
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044569715
- Cited by
- 2,323
- References
- 1
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Szoka, F., & Papahadjopoulos, D. (1978). Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.75.9.4194
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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