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Effect of Ca2+, Ba2+, and Sr2+ on Alginate Microbeads
Abstract
Microcapsules of alginate cross-linked with divalent ions are the most common system for cell immobilization. In this study, we wanted to characterize the effect of different alginates and cross-linking ions on important microcapsule properties. The dimensional stability and gel strength increased for high-G alginate gels when exchanging the traditional Ca2+ ions with Ba2+. The use of Ba2+ decreased the size of alginate beads and reduced the permeability to immunoglobulin G. Strontium gave gels with characteristics lying between calcium and barium. Interestingly, high-M alginate showed an opposite behavior in combination with barium and strontium as these beads were larger than beads of calcium-alginate and tended to swell more, also resulting in increased permeability. Binding studies revealed that different block structures in the alginate bind the ions to a different extent. More specifically, Ca2+ was found to bind to G- and MG-blocks, Ba2+ to G- and M-blocks, and Sr2+ to G-blocks solely.
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Metadata
- Authors
- Mørch, Ý. A., Donati, I., Strand, B. L., & Skjåk-Bræk, G.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-04-12
- Volume
- 7
- Issue
- 5
- Pages
- 1471-1480
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1525649312
- Cited by
- 863
- References
- 0
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- closed
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