The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Synthesis and Characterization of Hybrid Hyaluronic Acid-Gelatin Hydrogels
Open accessAbstract
Biomimetic hybrid hydrogels have generated broad interest in tissue engineering and regenerative medicine. Hyaluronic acid (HA) and gelatin (hydrolyzed collagen) are naturally derived polymers and biodegradable under physiological conditions. Moreover, collagen and HA are major components of the extracellular matrix (ECM) in most of the tissues (e.g., cardiovascular, cartilage, neural). When used as a hybrid material, HA-gelatin hydrogels may enable mimicking the ECM of native tissues. Although HA-gelatin hybrid hydrogels are promising biomimetic substrates, their material properties have not been thoroughly characterized in the literature. Herein, we generated hybrid hydrogels with tunable physical and biological properties by using different concentrations of HA and gelatin. The physical properties of the fabricated hydrogels including swelling ratio, degradation, and mechanical properties were investigated. In addition, in vitro cellular responses in both two and three-dimensional culture conditions were assessed. It was found that the addition of gelatin methacrylate (GelMA) into HA methacrylate (HAMA) promoted cell spreading in the hybrid hydogels. Moreover, the hybrid hydrogels showed significantly improved mechanical properties compared to their single component analogs. The HAMA-GelMA hydrogels exhibited remarkable tunability behavior and may be useful for cardiovascular tissue engineering applications.
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Self-citationControlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks
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Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146
“Similarly, Pedr on et al. used PEG-GelMA-HAMA hydrogels as a model matrix to mimic the glioma in order to study human glioblastoma multiforme (hGBM), the most common and aggressive form of brain cancer [98].”
BackgroundMethodInfluentialSelf-citation25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409
Self-citationHydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y., et al. (2014) · Lab Chip · doi:10.1039/c4lc00030g · Cited by 944
Self-citationDirect 3D bioprinting of perfusable vascular constructs using a blend bioink
Jia, W., Gungor-Ozkerim, P. S., Zhang, Y. S., Yue, K., Zhu, K., Liu, W., Pi, Q., Byambaa, B., Dokmeci, M. R., Shin, S. R., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.038 · Cited by 922
Self-citationDirect-write bioprinting of cell-laden methacrylated gelatin hydrogels
Bertassoni, L. E., Cardoso, J. C., Manoharan, V., Cristino, A. L., Bhise, N. S., Araujo, W. A., Zorlutuna, P., Vrana, N. E., Ghaemmaghami, A. M., Dokmeci, M. R., et al. (2014) · Biofabrication · doi:10.1088/1758-5082/6/2/024105 · Cited by 642
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Metadata
- Authors
- Camci-Unal, G., Cuttica, D., Annabi, N., Demarchi, D., & Khademhosseini, A.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-28
- Volume
- 14
- Issue
- 4
- Pages
- 1085-1092
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1993680967
- Cited by
- 343
- References
- 9
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- green
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