Synthesis and Performance of Novel Hydrogels Coatings for Implantable Glucose Sensors
Abstract
Novel hydrogel polymers were prepared, characterized, coated on implantable glucose sensors, and tested in vitro and in vivo. The effects of 2,3-dihydroxypropyl methacrylate (DHPMA) on the swelling, morphology, glass transition (T(g)), and water structure were studied. The results show that the degree of swelling increases with increasing DHPMA content. Scanning electron microscopy (SEM) studies identified uniform, porous structures in samples containing 60-90 mol % DHPMA. Glass-transition temperatures did not change significantly with DHPMA content, but the ratio of freezing to nonfreezing water tended to increase with DHPMA content. Sensors coated with different hydrogels were prepared and in vitro evaluations were performed. The 80% DHPMA hydrogels exhibited optimum sensitivity, response, and stability when coated directly onto the sensor or top of a polyurethane (PU) layer. The histology results show that 80% DHPMA samples exhibit reduced fibrosis and reduced inflammation, resulting in a longer functional life.
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Control sensor membranes at 28 days had a fibrous capsule of about 500 μm, while capsules around hydrogel-based sensors were roughly 30-60 μm.
“Control sensor membranes (epoxy-polyurethane) at 28 days were characterized with a fibrous capsule of ~500 Vm while the capsules around hydrogel-based sensors were roughly 30–60 Vm.15”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [15]
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Biocompatible Materials for Continuous Glucose Monitoring Devices
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- Authors
- Wang, C., Yu, B., Knudsen, B., Harmon, J., Moussy, F., & Moussy, Y.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Harmon, Julie
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-01-01
- Volume
- 9
- Issue
- 2
- Pages
- 561-567
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1977798324
- Cited by
- 63
- References
- 43
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB001640)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- hydrogel coating, implantable glucose sensor, hydrogel swelling, glass transition temperature, porous hydrogels, sensor sensitivity and stability, fibrosis, inflammation, biocompatibility
- MeSH terms
- Animals, Drug Implants, Glucose, Biosensing Techniques, Hydrogels, Rats
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