A long-term flexible minimally-invasive implantable glucose biosensor based on an epoxy-enhanced polyurethane membrane
Abstract
This paper describes the preparation method as well as the in vitro and in vivo evaluation of a novel flexible glucose biosensor designed for long-term subcutaneous implantation. An epoxy-enhanced polyurethane membrane, which includes ca. 30-40% epoxy resin adhesive and 50-70% polyurethane, has been developed and used for the first time as the outer protective membrane of the sensor. This new membrane was developed to increase the in vivo durability and lifetime of implantable biosensors. This epoxy-polyurethane membrane was shown to be porous and is of excellent durability. A sensor with such a membrane shows excellent long-term stability and can last for 4-8 months in solutions at room temperature. To verify the in vivo performance of the sensor, nine sensors were implanted in three rats and tested regularly. Eight sensors kept functioning well in the rats for 10-56 days. The ninth sensor was damaged during implantation. All original sensitivity data as well as four response curves obtained at days 7, 17, 52 and 56, respectively are presented.
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Only one of nine sensors functioned for 56 days, and seven of nine lost functionality within 17 days or less.
“However, only one of the nine sensors functioned this long. Indeed, seven of the nine sensors lost functionality in 17 d or less.141”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [141]
Epoxy-polyurethane membranes allowed fabrication of functional glucose sensors in rats for up to 56 days with good sensitivity.
“The authors reported that this membrane allowed for the fabrication of functional glucose sensors in rats for up to 56 days with good sensitivity.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [141]
Cites
Cosnier, S. (1999) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(99)00024-x · Cited by 769 · see citing works
Characterization of implantable biosensor membrane biofouling
Wisniewski, N. A., Moussy, F. G., & Reichert, W. M. (2000) · Fresenius Journal of Analytical Chemistry · doi:10.1007/s002160051556 · Cited by 351 · see citing works
Self-citationDesign and in vitro studies of a needle-type glucose sensor for subcutaneous monitoring
Bindra, D. S., Zhang, Y., Wilson, G. S., Sternberg, R., Thevenot, D. R., Moatti, D., & Reach, G. (1991) · Analytical Chemistry · doi:10.1021/ac00017a008 · Cited by 309 · see citing works
Sensors for glucose monitoring: technical and clinical aspects
Koschinsky, T., & Heinemann, L. (2001) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.188 · Cited by 288 · see citing works
Continuous Glucose Sensing with a Fluorescent Thin‐Film Hydrogel
Suri, J. T., Cordes, D. B., Cappuccio, F. E., et al. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200352405 · Cited by 149 · see citing works
Silica-based hybrid materials as biocompatible coatings for glucose sensors
Kros, A., Gerritsen, M., Sprakel, V. S. I., et al. (2001) · Sensors and Actuators B Chemical · doi:10.1016/s0925-4005(01)00933-9 · Cited by 94 · see citing works
Influence of inflammatory cells and serum on the performance of implantable glucose sensors
Gerritsen, M., Jansen, J. A., Kros, A., Vriezema, D. M., Sommerdijk, N. A. J. M., Nolte, R. J. M., Lutterman, J. A., van Hövell, S. W. F. M., & van der Gaag, A. (2000) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(200101)54:1 · Cited by 89 · see citing works
A new amperometric glucose microsensor: in vitro and short-term in vivo evaluation
Ward, W. K., Jansen, L. B., Anderson, E., Reach, G., Klein, J.-C., & Wilson, G. S. (2002) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(01)00268-8 · Cited by 81 · see citing works
Bone morphogenetic protein encapsulated with a biodegradable and biocompatible polymer
Isobe, M., Amagasa, T., Oida, S., Yamazaki, Y., Ishihara, K., & Nakabayashi, N. (1996) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199611)32:3 · Cited by 76 · see citing works
Glucose sensor with improved haemocompatibilty
Yang, Y. (2000) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(00)00082-8 · Cited by 49 · see citing works
Coil-type implantable glucose biosensor with excess enzyme loading
Yu, B. (2005) · Frontiers in bioscience · doi:10.2741/1547 · Cited by 42 · see citing works
Self-citationGeckeler, K. E., Wacker, R., Martini, F., et al. (2003) · Cellular Physiology and Biochemistry · doi:10.1159/000071866 · Cited by 33 · see citing works
Hiratsuka, A., Ikebukuro, K., Karube, I., et al. (2001) · The Analyst · doi:10.1039/b008036p · Cited by 32 · see citing works
Mechanical properties and biocompatibility of two polyepoxy matrices: DGEBA-DDM and DGEBA-IPD
Berruet, R. G., Vinard, E., Calle, A., et al. (1987) · Biomaterials · doi:10.1016/0142-9612(87)90058-5 · Cited by 18 · see citing works
Ishihara, K., Nakabayashi, N., Nishida, K., Sakakida, M., & Shichiri, M. (1994) · ACS symposium series · doi:10.1021/bk-1994-0556.ch016 · Cited by 13 · see citing works
Yajima, S., Suzuki, K., & Kimura, K. (2000) · Analytical Sciences · doi:10.2116/analsci.16.899 · Cited by 8 · see citing works
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Electrochemical Glucose Sensors and Their Applications in Diabetes Management
Heller, A., & Feldman, B. (2008) · Chemical Reviews · doi:10.1021/cr068069y · Cited by 1,707 · see citing works
Electroconductive hydrogels: Synthesis, characterization and biomedical applications
Guiseppi-Elie, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.052 · Cited by 646 · see citing works
Biocompatible Materials for Continuous Glucose Monitoring Devices
Nichols, S. P., Koh, A., Storm, W. L., Shin, J. H., & Schoenfisch, M. H. (2013) · Chemical Reviews · doi:10.1021/cr300387j · Cited by 347 · see citing works
Koschwanez, H. E., & Reichert, W. M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.03.034 · Cited by 181 · see citing works
Use of hydrogel coating to improve the performance of implanted glucose sensors
Yu, B., Wang, C., Ju, Y. M., West, L., Harmon, J., Moussy, Y., & Moussy, F. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2007.11.010 · Cited by 105 · see citing works
Self-citationHelton, K. L., Ratner, B. D., & Wisniewski, N. A. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500318 · Cited by 102 · see citing works
Koschwanez, H. E., Yap, F. Y., Klitzman, B., & Reichert, W. M. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31824 · Cited by 69 · see citing works
Synthesis and Performance of Novel Hydrogels Coatings for Implantable Glucose Sensors
Wang, C., Yu, B., Knudsen, B., Harmon, J., Moussy, F., & Moussy, Y. (2008) · Biomacromolecules · doi:10.1021/bm701102y · Cited by 63 · see citing works
Self-citationStudy of the effects of tissue reactions on the function of implanted glucose sensors
Dungel, P., Long, N., Yu, B., Moussy, Y., & Moussy, F. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31593 · Cited by 47 · see citing works
Self-citation
- Authors
- Yu, B., Long, N., Moussy, Y., & Moussy, F.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Moussy, Francis
- ORCID
- Yu, Bazhang
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 21
- Issue
- 12
- Pages
- 2275-2282
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2081012836
- Cited by
- 141
- References
- 16
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biosensors and Bioelectronics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- flexible biosensors, subcutaneous implantation, long-term sensor stability, porous membranes, sensor sensitivity, rat implantation
- MeSH terms
- Animals, Blood Glucose, Cattle, Elasticity, Enzymes, Immobilized, Epoxy Compounds, Equipment Design, Glucose Oxidase, Membranes, Artificial, Polyurethanes, Blood Glucose Self-Monitoring, Biosensing Techniques, Equipment Failure Analysis, Prostheses and Implants, Coated Materials, Biocompatible, Rats
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