The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Functionalized Amphiphilic Hyperbranched Polymers for Targeted Drug Delivery
Abstract
Amphiphilic hyperbranched core-shell polymers with folate moieties as the targeting groups were synthesized and characterized. The core of the amphiphilic polymers was hyperbranched aliphatic polyester Boltorn H40. The inner part and the outer shell of the amphiphilic polymers were composed of hydrophobic poly(epsilon-caprolactone) segments and hydrophilic poly(ethylene glycol) (PEG) segments, respectively. To achieve tumor cell targeting property, folic acid was further incorporated to the surface of the amphiphilic polymers via a coupling reaction between the hydroxyl group of the PEG segment and the carboxyl group of folic acid. The polymers were characterized by (1)H NMR, (13)C NMR, and combined size-exclusion chromatography and multiangle laser light scattering analysis. The nanoparticles of the amphiphilic polymers prepared by dialysis method were characterized by transmission electron microscopy and particle size analysis. Two antineoplastic drugs, 5-fluorouracil and paclitaxel, were encapsulated into the nanoparticles. The drug release property and the targeting of the drug-loaded nanoparticles to different cells were evaluated in vitro. The results showed the drug-loaded nanoparticles exhibited enhanced cell inhibition because folate targeting increased the cytotoxicity of drug-loaded nanoparticles against folate receptor expressing tumor cells.
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Citations
Cites
Wang, F., Bronich, T. K., Kabanov, A. V., Rauh, R. D., & Roovers, J. (2005) · Bioconjugate Chemistry · doi:10.1021/bc049784m · Cited by 317
Cited by
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270
Drug delivery using multifunctional dendrimers and hyperbranched polymers
Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.534981 · Cited by 156
Phan, Q. T., Le, M. H., Le, T. T. H., Tran, T. H. H., Xuan, P. N., & Ha, P. T. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.003 · Cited by 68
Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications
Liu, X., Fan, X., Jiang, L., Loh, X. J., Wu, Y.-L., & Li, Z. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01883a · Cited by 43
Zhu, Y., Romain, C., Poirier, V., & Williams, C. K. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b00225 · Cited by 35
Prebiotic alternatives to proteins: Structure and function of hyperbranched polyesters
Mamajanov, I., Callahan, M. P., Dworkin, J. P., & Cody, G. D. (2015) · Origins of Life and Evolution of Biospheres · doi:10.1007/s11084-015-9430-9 · Cited by 17
Metadata
- Authors
- Chen, S., Zhang, X.-Z., Cheng, S.-X., Zhuo, R.-X., & Gu, Z.-W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-30
- Volume
- 9
- Issue
- 10
- Pages
- 2578-2585
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2016502802
- Cited by
- 258
- References
- 1
- FWCI
- 19.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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