The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Functionalized Amphiphilic Hyperbranched Polymers for Targeted Drug Delivery
Abstract
Amphiphilic hyperbranched core-shell polymers with folate moieties as the targeting groups were synthesized and characterized. The core of the amphiphilic polymers was hyperbranched aliphatic polyester Boltorn H40. The inner part and the outer shell of the amphiphilic polymers were composed of hydrophobic poly(epsilon-caprolactone) segments and hydrophilic poly(ethylene glycol) (PEG) segments, respectively. To achieve tumor cell targeting property, folic acid was further incorporated to the surface of the amphiphilic polymers via a coupling reaction between the hydroxyl group of the PEG segment and the carboxyl group of folic acid. The polymers were characterized by (1)H NMR, (13)C NMR, and combined size-exclusion chromatography and multiangle laser light scattering analysis. The nanoparticles of the amphiphilic polymers prepared by dialysis method were characterized by transmission electron microscopy and particle size analysis. Two antineoplastic drugs, 5-fluorouracil and paclitaxel, were encapsulated into the nanoparticles. The drug release property and the targeting of the drug-loaded nanoparticles to different cells were evaluated in vitro. The results showed the drug-loaded nanoparticles exhibited enhanced cell inhibition because folate targeting increased the cytotoxicity of drug-loaded nanoparticles against folate receptor expressing tumor cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Wang, F., Bronich, T. K., Kabanov, A. V., Rauh, R. D., & Roovers, J. (2005) · Bioconjugate Chemistry · doi:10.1021/bc049784m · Cited by 317
Cited by
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270
Drug delivery using multifunctional dendrimers and hyperbranched polymers
Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.534981 · Cited by 156
Phan, Q. T., Le, M. H., Le, T. T. H., Tran, T. H. H., Xuan, P. N., & Ha, P. T. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.05.003 · Cited by 68
Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications
Liu, X., Fan, X., Jiang, L., Loh, X. J., Wu, Y.-L., & Li, Z. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01883a · Cited by 43
Zhu, Y., Romain, C., Poirier, V., & Williams, C. K. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b00225 · Cited by 35
Metadata
- Authors
- Chen, S., Zhang, X.-Z., Cheng, S.-X., Zhuo, R.-X., & Gu, Z.-W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-30
- Volume
- 9
- Issue
- 10
- Pages
- 2578-2585
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2016502802
- Cited by
- 258
- References
- 1
- FWCI
- 19.27
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
