The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
pH-Responsive Carrier System Based on Carboxylic Acid Modified Mesoporous Silica and Polyelectrolyte for Drug Delivery
Abstract
An efficient pH-responsive carrier system has been constructed by oppositely charged ionic interaction between carboxylic acid modified SBA-15 silica rods and polyelectrolyte. Active molecules such as vancomycin can be stored and released from the pore voids of SBA-15 by changing pH values at will. The amount of vancomycin stored in the pores of sample based on carboxylic acid modified SBA-15 rods and poly(dimethyldiallylammonium chloride) is up to 36.4 wt % at pH 6.8. When the pH is at mild acidity, vancomycin is steadily released from the pores of SBA-15. Both nitrogen adsorption−desorption isothems and X-ray diffraction patterns show that this system possesses stable mesostructure, which will be considered an interesting alternative to a polymeric delivery system.
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Metadata
- Authors
- Yang, Q., Wang, S., Fan, P., Wang, L., Di, Y., Lin, K., & Xiao, F.-S.
- Venue
- Chemistry of Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-11-01
- Volume
- 17
- Issue
- 24
- Pages
- 5999-6003
- ISSN
- 0897-4756 (ISSN-L)
- 1520-5002
- OpenAlex
- W2057441531
- Cited by
- 490
- References
- 36
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
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