Modulators of Protein–Protein Interactions

Cited by (523)

Items 401–500 of 523

1. Reengineering of a Proteomimetic Pan‐Ras Inhibitor into a Ras Degrader
   Joseph F. Ongkingco, Seong Ho Hong, Eugene D. Toth, Thu Trang Nguyễn, Paramjit S. Arora · 2025 · Angewandte Chemie International Edition
2. Structure-based PROTAC Design
   Darryl B. McConnell · 2020 · Royal Society of Chemistry eBooks
3. Discovery and Use of Natural Products and Derivatives as Chemical Probes
   Masaki Kita, Hideo Kigoshi · 2020 · Royal Society of Chemistry eBooks
4. Tailoring peptides and peptidomimetics for targeting protein–protein interactions
   Łukasz Berlicki · 2022 · Elsevier eBooks
5. Research advancements in molecular glues derived from natural product scaffolds: Chemistry, targets, and molecular mechanisms
   Lina Yin, Tingting Niu, Ling Li, Wei Dong Yu, Bo Han, Asma Rehman, Ke‐Wu Zeng · 2025 · Chinese Herbal Medicines
6. A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1–JAZs Agonists and Antagonists
   Yousuke Takaoka, Kengo Hayashi, Kaho Suzuki, Ika Nurul Azizah, Minoru Ueda · 2019 · Methods in molecular biology
7. Evolution of Macromolecular Docking Techniques: The Case Study of Nickel and Iron Metabolism in Pathogenic Bacteria
   Francesco Musiani, Stefano Ciurli · 2015 · Molecules
8. Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics
   Gloria Ruiz‐Gómez, John Hawkins, Jenny Philipp, Georg Künze, Robert Wodtke, Reik Löser, Karim Fahmy, Maria Teresa Pisabarro · 2016 · PLoS ONE
9. Semiempirical molecular orbital calculations for 3d-4f complexes towards artificial metalloproteins
   Takashiro Akitsu · 2017 · International Journal of Pharma Sciences and Scientific Research
10. Triglycine-Based Approach for Identifying the Substrate Recognition Site of an Enzyme
    Ki Hyun Nam · 2019 · Crystals
11. Emerging Role of Structural and Systems Biology in Anticancer Therapeutics
    Manzar Alam, Ahmad Abu Turab Naqvi, Md. Imtaiyaz Hassan · 2022 · Springer eBooks
12. Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
    Jennifer A. Miles, Fruzsina Hóbor, James Ward Taylor, Christian Tiede, Philip R. Rowell, Chi H. Trinh, Brian R. Jackson, Fatima Nadat, Hannah F. Kyle, Basile I. M. Wicky et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
13. α-Hydrazino Acid Insertion Governs Peptide Organization in Solution by Local Structure Ordering
    Luka Kavčič, Gregor Ilc, Baifan Wang, Kristina Vlahoviček‐Kahlina, Ivanka Jerić, Janez Plavec · 2024 · ACS Omega
14. Alphappimi: a comprehensive deep learning framework for predicting PPI-modulator interactions
    Dayan Liu, Tao Song, Shuang Wang, Xue Li, Peifu Han, Jianmin Wang, Shudong Wang · 2025 · Journal of Cheminformatics
15. Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship
    Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert Jan Markvoort, Galen P. Miley, Luc Brunsveld · 2025 · Angewandte Chemie International Edition
16. Macrocyclic peptides as protein–protein interaction modulators: a review
    Erin Ann Sunny Sunny, Sandhya Sadanandan · 2026 · Organic & Biomolecular Chemistry
17. Drug Design Methods to Regulate Protein–Protein Interactions
    Krishna Mohan Poluri, Khushboo Gulati, Deepak Kumar Tripathi, Nupur Nagar · 2023 · Springer eBooks
18. Phosphorylation-responsive system for enzyme activity detection based on peptide-cucurbit[8]uril interactions
    Jun Hu, Shihao Wang, Yufen Zhao, Li Gao, Yong‐Xiang Chen · 2024 · Dyes and Pigments
19. SFM-Net: Selective Fusion of Multiway Protein Feature Network for Predicting Binding Affinity Changes upon Mutations
    Chunting Liu, Sudong Cai, Tong Pan, Hiroyuki Ogata, Jiangning Song, Tatsuya Akutsu · 2025 · Journal of Chemical Information and Modeling
20. Mass spectrometric analysis of dimer-disrupting mutations in Plasmodium triosephosphate isomerase
    Debarati Bandyopadhyay, Sunita Prakash, Kallol Gupta, P. Balaram · 2016 · Analytical Biochemistry
21. An expeditious synthetic route to proteomimetic foldamers
    Vaibhav V. Karekar, Bapurao A. Bhoge, Ishu Saraogi · 2018 · New Journal of Chemistry
22. Peptidomimetics of α‐Helical and β‐Strand Protein Binding Epitopes
    Nina Bionda, Rudi Fasan · 2015 · Wiley eBooks
23. Multivalent Protein Recognition Using Synthetic Receptors
    Akash Gupta, Moumita Ray, Vincent M. Rotello · 2017
24. Kinetics and dynamics of single-molecule multivalent interactions revealed by plasmon-enhanced fluorescence
    Kasper R. Okholm, Sjoerd W. Nooteboom, Vincenzo Lamberti, Swayandipta Dey, Peter Zijlstra, Duncan S. Sutherland · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
25. Understanding the Role of Flavonoid Based Small Molecules in Modulating the Oncogenic Protein-Protein Interactions: A Quest for Therapeutic Arsenal
    Abhijit Karmakar, Tamanna Mallick, Chandrani Fouzder, Alpana Mukhuty, Samiran Mondal, Rakesh Kundu, Naznin Ara Begum · 2021 · Journal of Molecular Structure
26. Caspases activity assay procedures
    Sourabh Satapathy, Shivam Kumar, Vaibhav Nigam, Balak Das Kurmi, Ankur Vaidya, Akash Ved, Preeti Patel · 2024 · Elsevier eBooks
27. Impairing protein–protein interactions in an essential tRNA modification complex: An innovative antimicrobial strategy against Pseudomonas aeruginosa
    Michela Bollati, Elettra Fasola, Stefano Pieraccini, Francesca Freddi, Paolo Cocomazzi, Francesco Oliva, Merlin Klußmann, Angelo Maspero, Umberto Piarulli, Silvia Ferrara et al. · 2024 · Journal of Peptide Science
28. DNA‐Mimikry‐Foldamer‐Erkennung eines chromosomalen Proteins
    Deepak Deepak, Jiaojiao Wu, Valentina Corvaglia, Lars Allmendinger, Michael Scheckenbach, Philip Tinnefeld, Ivan Huc · 2024 · Angewandte Chemie
29. Examining the Effect of an Anion-Binding Reagent on the Structure of Deprotonated Leucine Enkephalin Using Cryogenic-Ion Infrared Action Spectroscopy
    Madeline Schultz, Nwanne D. Banor, Katja Ober, América Yareth Torres-Boy, Maleesha T. Fernando, Miyuru M. Wellalage, Neil A. Ellis, Gert von Helden, Daniel A. Thomas · 2025 · The Journal of Physical Chemistry A
30. Computational Investigation of Octanediamide Derivatives as Potential Inhibitors of Monkeypox Virus: HF and Molecular Docking Approaches
    Gamze Tüzün, Koray Sayın, Burak Tüzün · 2025 · Turkish computational and theoretical chemistry/Turkish computational and theoretical chemistry :
31. Rhodium‐Catalyzed Regioselective C7 Ar ‐(Acyl)alkylation of Tryptophan With Allyl Alcohols and Its Late‐Stage Peptide Exemplification
    Disha Harsukhbhai Tank, Somnath Arjun Borade, Mukul Yadav, Siva S. Panda, Kiran Bajaj, Rajeev Sakhuja · 2025 · Chemistry - An Asian Journal
32. Phage Display as a Promising Platform for Peptide Drug Discovery
    Babak Bakhshinejad, Andreas Kjær · 2026 · Pharmaceuticals
33. Macrocyclic peptides and peptidomimetics as modulators of protein–protein interactions
    Rajesh Parmar, Vidit Shrivastava, Gurmeet Kaur, Bhupesh Goyal, Rahul Jain · 2026 · RSC Medicinal Chemistry
34. Oligooxopiperazines as Topographical Helix Mimetics
    Brooke Bullock Lao, Paramjit S. Arora · 2016 · Topics in heterocyclic chemistry
35. The use of 4,4,4-trifluorothreonine to stabilize extended peptide structures and mimic β-strands
    Yaochun Xu, Isabelle Correia, Tâp Ha‐Duong, Nadjib Kihal, J.L. Soulier, Julia Kaffy, Benoı̂t Crousse, Olivier Lequin, Sandrine Ongeri · 2017 · Beilstein Journal of Organic Chemistry
36. Discovery and Development of Keap1-Nrf2 Protein-Protein Interaction Inhibitors
    Zhengyu Jiang, Qidong You · 2018 · Springer eBooks
37. Step IIIb: The Drug-Like Chemical Diversity Pool: Diverse and Targeted Compound Collections
    Pierfausto Seneci · 2018 · Elsevier eBooks
38. Imaginative Order from Reasonable Chaos: Conformation-Driven Activity and Reactivity in Exploring Protein–Ligand Interactions
    Alexander F. Moore, David J. Newman, Shoba Ranganathan, Fei Liu · 2018 · Australian Journal of Chemistry
39. Transition Metal Catalyzed Cross-Coupling Reactions
    Ioannis D. Kostas · 2021 · MDPI eBooks
40. Exploring the Binding Mechanism of a Supramolecular Tweezer CLR01 to 14-3-3σ Protein via Well-Tempered Metadynamics
    Xin Zhou, Mingsong Shi, Xin Wang, Dingguo Xu · 2022 · Frontiers in Chemistry
41. Protein imprinting via epitope approach: An overview
    Neha Gupta, Meenakshi Singh · 2023 · Elsevier eBooks
42. From Protein Structures to Functional Biomimetics
    Tom N. Grossmann, Canan Durukan · 2024 · Synlett
43. How Do DNA Molecular Springs Modulate Protein–Protein Interactions: Experimental and Theoretical Results
    Kecheng Zhang, Jingze Duan, Cong Li, Chen Song, Zhixing Chen · 2024 · Biochemistry
44. C‐Terminal ‐Aib‐L–Leu‐OMe Segment Promotes Schellman Loop from α‐Peptides with Alternating L–Leu and Aib Residues in the Crystal State
    Mintu Debnath, Rajib Sarkar, Sujay Kumar Nandi, Debasish Haldar · 2017 · ChemistrySelect
45. Overview of Protein-Protein Interactions and Small-Molecule Inhibitors Under Clinical Development
    Guoqiang Dong, Chunquan Sheng · 2018 · Springer eBooks
46. Design, synthesis and evaluation of E2‐25K derived stapled peptides
    Morag E. Watson, Daniel Scott, Craig J. Jamieson, Robert Layfield, Andrew M. Mason · 2020 · Peptide Science
47. High Throughput Screening Methods for PPI Inhibitor Discovery
    Sean P. Doyle, Xiulei Mo, Kun Qian, Danielle Cicka, Qiankun Niu, Haian Fu · 2020 · Royal Society of Chemistry eBooks
48. Peptide‐Directed Binding for the Discovery of Modulators of α‐Helix‐Mediated Protein–Protein Interactions: Proof‐of‐Concept Studies with the Apoptosis Regulator Mcl‐1
    Andrew Michael Beekman, Maria Anne O'Connell, Lesley A. Howell · 2017 · Angewandte Chemie
49. Macrocyclic Organo‐Peptide Hybrids by Intein‐Mediated Ligation: Synthesis and Applications
    John R. Frost, Rudi Fasan · 2017 · Wiley eBooks
50. Coarse-grained modeling with constant pH of the protein complexation phenomena
    Sergio Alejandro Poveda Cuevas · 2017 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
51. A general framework for straightforward model construction of multi-component thermodynamic equilibrium systems
    Nick H. J. Geertjens, Pim J. de Vink, Tim Wezeman, Albert Jan Markvoort, Luc Brunsveld · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
52. Inhibition of VEGF/VEGFR1 interaction by a series of C-terminal modified cyclic peptides
    2015 · Receptors & Clinical Investigation
53. Modulation of protein : protein interactions in inflammatory diseases
    Barbara A. Zarzycka · 2015
54. Die Hemmung von Protein‐Protein‐Wechselwirkungen: neue Ansätze zur Entwicklung von Wirkstoffen gegen Tropenkrankheiten
    Thorsten Berg · 2017 · Angewandte Chemie
55. Current Challenges in the Computational Modelling of Molecular Recognition Processes
    Lucía Pérez-Regidor, Joan Guzman‐Caldentey, Carlos F. Rodríguez, Jean‐Marc Billod, Juan Nogales, Sonsoles Martín‐Santamaría · 2017 · Royal Society of Chemistry eBooks
56. Maßgeschneiderte Liganden für Protein-Protein-Interaktionen
    Christian Heid, Kyra Kujawski, Thomas H. Schrader · 2018 · BIOspektrum
57. Effects of chiral center on an all‐hydrocarbon tethered peptide
    Xiaodong Shi, Kuan Hu, Hao Ran Geng, Zhihong Liu, Feng Yin, Zigang Li · 2018 · Peptide Science
58. Synthesis and Structural Stability of α-Helical Gold(I)-Metallopeptidesy
    Pol Besenius, Lydia Zengerling, Benedict Kemper, Ute A. Hellmich · 2020 · Synlett
59. Hydrogen Bond Surrogate Stabilized Helices as Protein–Protein Interaction Inhibitors
    Daniel Y. Yoo, Paramjit S. Arora · 2020 · Royal Society of Chemistry eBooks
60. In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor Growth in Cancer Stem Cell
    Kuan Hu · 2021 · Springer theses
61. Synthesis of In-Tether Chiral Center Peptides and Their Biophysical Properties Study
    Kuan Hu · 2021 · Springer theses
62. 29th Annual GP2A Medicinal Chemistry Conference
    Jean‐Jacques Hélesbeux, Laura Carro, Florence O. McCarthy, Vânia M. Moreira, Francesca Giuntini, Niamh M. O’Boyle, Susan E. Matthews, Gülşah Bayraktar, Samuel Bertrand, Christophe Rochais et al. · 2021 · Pharmaceuticals
63. Introduction
    Kuan Hu · 2021 · Springer theses
64. Faculty Opinions recommendation of Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP.
    Kausik Chakraborty · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
65. Faculty Opinions recommendation of Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.
    Miles Congreve, Mark Pickworth · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
66. Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction
    Wan Gi Byun · 2022 · Springer theses
67. Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate
    Junyang Liu, Shoubin Tang, Jia‐Lei Yan, Tao Ye · 2023 · Molecules
68. A Cost-Effective Immobilization Method for MBP Fusion Proteins on Microtiter Plates Using a Gelatinized Starch–Agarose Mixture and Its Application for Convenient Protein–Protein Interaction Analysis
    Yuri Emoto, Ryoya Katayama, Emi Hibino, Sho Ishihara, Natsuko Goda, Takeshi Tenno, Yoshihiro Kobashigawa, Hiroshi Morioka, Hidekazu Hiroaki · 2023 · Methods and Protocols
69. Approaching novel antibiotic targets using peptidomimetics
    Felix M. Paulussen · 2023
70. Network biology and bioinformatics-based framework to identify the impacts of SARS-CoV-2 infections on lung cancer and tuberculosis
    Abdul Waaje, Md Sumon Sarkar, Md Zahidul Islam · 2024 · medRxiv
71. Modulation of the KEAP1–NRF2 Pathway for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds
    José Clerigué, Jorge Pascual-Guerra, Rafael M. Leon, José Carlos Menéndez · 2024 · Neuromethods
72. Reengineering of a Proteomimetic Pan‐Ras Inhibitor into a Ras Degrader
    Joseph F. Ongkingco, Seong Ho Hong, Eugene D. Toth, Thu Trang Nguyễn, Paramjit S. Arora · 2025 · Angewandte Chemie
73. π‐Turns in Peptides: A Crystal‐State Literature Survey
    Barbara Biondi, Fernando Formaggio, Claudio Toniolo, Cristina Peggion, Marco Crisma · 2025 · Journal of Peptide Science
74. Photoresponsive molecular tweezers modulate Taspase 1 activity
    Antonio Figueroa Bietti, Alisa-Maite A. Kauth, Katrin Hommel, Mike Blueggel, Laurenz Mohr, Felix C. Niemeyer, Christine Beuck, Peter Bayer, Shirley K. Knauer, Bart Jan Ravoo et al. · 2025 · RSC Chemical Biology
75. Cyclic Peptides for PPI Drug Discovery
    Honggang Hu, Xiang Li · 2025
76. Integrating SICLOPPS screening with next-generation sequencing for the discovery of cyclic peptide modulators of protein–protein interactions
    Juan Antonio Sarmiento Muro, Ali Tavassoli · 2025 · Methods in enzymology on CD-ROM/Methods in enzymology
77. Fundamental of Theoretical Calculations on Protein Systems
    Jinjin Li, Yanqiang Han · 2025 · Machine Learning in Protein Science
78. Progress on molecular glue degraders
    Jiaqi Chen, Zhiheng Deng, Haoxiang Li, Lei Liu · 2025 · Scientia Sinica Chimica
79. Engineering a new tripartite split-ccGFP system from Corynactis californica for detecting protein–protein interactions
    Thomas M. Groseclose, Erin Kober, Jennifer M. Zupancic, Claire K. McLelland, Lexy A Lujan, Yuliya A. Kunde, Sarah C. Mozden, Nileena Velappan, Antonietta M. Lillo, Emilia A. Solomon et al. · 2025 · Scientific Reports
80. Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship
    Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert Jan Markvoort, Galen P. Miley, Luc Brunsveld · 2025 · Angewandte Chemie
81. A Heterogeneous Graph Framework for Inference of Metabolite–Protein-Drug Interaction Networks
    Yuntao Lu, C.Sriram C.Sriram · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
82. Computational Methods and Tools for the Design and Development of Small Molecule Inhibitors Targeting PPIs
    Arpan Chowdhury, Siva Murru · 2026 · Challenges and advances in computational chemistry and physics
83. Reinforcement Learning-Driven Conversion Designed Minibinders to Small Molecules Targeting Porcine Nectin-1 IgV Domain for Anti-PRV Therapy
    Zigong Wei, Lin Wei, Y. Angela Hu, Peng Chen, Yuhua Chen, Keke Wang, Jun Weng, Banbin Xing, Ke Ming, Zhiyong Wu et al. · 2026 · Research Square
84. Selective modulation of the Protein Kinase CK2 : discovery, syntheses and characterization of non-ATP site inhibitors of CK2
    Benoît Bestgen · 2015
85. Protein Surface Recognition with Urea-based foldamers : application to the design of ligands targeting histone chaperone proteins
    Johanne Mbianda · 2018 · theses.fr (ABES)
86. NMR study of 14-3-3 protein-protein interactions and modulation thereof by small molecules
    João Filipe Neves · 2019
87. Conception de peptides dérivés de la crotoxine et évaluation sur le canal ΔF508CFTR : une nouvelle approche pour le traitement de la mucoviscidose
    Marc Ravatin · 2020
88. Efficient exploration of peptide libraries using active learning with AlphaFold-based screening
    Jokent T. Gaza, Jherome Brylle Woody Santos, Bhumika Singh, Ramon Alain Miranda Quintana, Alberto Pérez · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
89. Use of Computational Models to Investigate Human Targets of Small Ubiquitous Molecules
    Elena Frasnetti, Francesco Frigerio, Fabrizio Cinquini, Stefano Artin Serapian, Silvia Pavoni, Giorgio Colombo · 2026 · ChemBioChem
90. p ‐Sulfonatocalix[4]arene‐Based Ratiometric Fluorescence Chemosensor Array for the Differential Detection of Polycationic Peptides
    Joana N. Martins, Márcia Pessêgo, Lucia Méndez‐Gómez, Hanieh Mahmoodi, Javier Montenegro, Luis García‐Río, João Carlos Lima, Nuno Basílio · 2026 · ChemistryEurope
91. Modeling Peptide–Protein Interactions with MELD : A Physics‐based Framework for Structure, Affinity, and Design
    Guadalupe ÁLVAREZ, Yisel Martínez‐Noa, Bhumika Singh, Jokent T. Gaza, Qianchen Liu, Alberto Perez · 2026 · Wiley eBooks
92. Artificial Synthetic Protein Mimetics As Pathology-Targeted Therapeutics
    Ryan A. Dohoney · 2026
93. Molecular Glue and Phosphorylation-Dependent 14-3-3 Recruitment to p53 with an Engineered Interaction Cassette
    Diana C. Muñoz-Lasso, Yan Ni, Glenn Weber, Federica Eduati, Roderick L. Beijersbergen, Christian Ottmann, Luc Brunsveld · 2026 · ACS Chemical Biology
94. The yeast two-hybrid method as a learning vehicle for undergraduate independent research
    Brian Aguilera, Jessica Walnut, David Chakravorty, Sarah M. Assmann · 2026 · Journal of Microbiology and Biology Education
95. Targeting the IL-17A Cytokine Interface: Structural Insights and Small-Molecule Modulators
    Gyeong Un Kim, Ansoo Lee, Sanghee Lee, Byungsun Jeon, Hahnbeom Park, Taek Kang, Hyunah Choo · 2026 · Journal of Medicinal Chemistry
96. A doubly crosslinked macrocyclic peptide with a cleavable disulfide bond: transformation into a bioactive a-helical peptide in response to intracellular stimuli
    Tetsuya Yasukagawa, Junya Chiba, Satoru Yokoyama, Yue Zhou, Yuki Ohishi, Masahiko Inoûye · 2026 · SSRN Electronic Journal
97. Discovery of Small Peptides as Dual Inhibitors of IL-4 and IL-13 Signaling
    Chase Mei, Paul Atawuchugi, Tawshik Iqbal, Marc Stolyar, Marin Penner, Francis A. Acquah, John Fetse · 2026 · ACS Medicinal Chemistry Letters
98. BindingDB Entry 50012538: Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance.
    BindingDB · 2022 · UC San Diego
99. BindingDB Entry 50007600: Clinical candidates modulating protein-protein interactions: The fragment-based experience.
    BindingDB · 2021 · UC San Diego
100. BindingDB Entry 7643: A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.
     BindingDB · 2017 · UC San Diego