Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 406

The DOI matches its Crossref record.

Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues

Open access
Needham, Larry L., Grandjean, Philippe, Heinzow, Birger, Jørgensen, Poul J., Nielsen, Flemming, Patterson, Donald G., Sjödin, Andreas, Turner, Wayman E., Weihe, Pal·2011·Environmental Science & Technology
DOI 10.1021/es1019614
Open this paper in CoChat — free account

Abstract

Passage of environmental chemicals across the placenta has important toxicological consequences, as well as for choosing samples for analysis and for interpreting the results. To obtain systematic data, we collected in 2000 maternal and cord blood, cord tissue, placenta, and milk in connection with births in the Faroe Islands, where exposures to marine contaminants is increased. In 15 sample sets, we measured a total of 87 environmental chemicals, almost all of which were detected both in maternal and fetal tissues. The maternal serum lipid-based concentrations of organohalogen compounds averaged 1.7 times those of cord serum, 2.8 times those of cord tissue and placenta, and 0.7 those of milk. For organohalogen compounds detectable in all matrices, a high degree of correlation between concentrations in maternal serum and the other tissues investigated was generally observed (r(2) > 0.5). Greater degree of chlorination resulted in lower transfer from maternal serum into milk. Concentrations of pentachlorbenzene, γ-hexachlorocyclohexane, and several polychlorinated biphenyl congeners with low chlorination were higher in fetal samples and showed poor correlation with maternal levels. Perfluorinated compounds occurred in lower concentrations in cord serum than in maternal serum. Cadmium, lead, mercury, and selenium were all detected in fetal samples, but only mercury showed close correlations among concentrations in different matrices. Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1021/es1019614

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 40

  1. Grandjean P., 2008, Basic Clin. Pharmacol. Toxicol., 102, 73, 10.1111/j.1742-7843.2007.00114.x · DOI
  2. Andersen H. R., 2000, Toxicology, 144, 121, 10.1016/S0300-483X(99)00198-5 · DOI
  3. Grandjean P., 1994, Clin. Chem., 40, 1360, 10.1093/clinchem/40.7.1360 · DOI
  4. Meijer L., 2008, Environ. Sci. Technol., 42, 3428, 10.1021/es702446p · DOI
  5. Nakamura T., 2008, Sci. Total Environ., 394, 39, 10.1016/j.scitotenv.2008.01.012 · DOI
  6. Rogan W. J., 1986, J. Pediatr., 109, 335, 10.1016/S0022-3476(86)80397-3 · DOI · Paper page
  7. Smolders R., 2009, Environ. Health, 8, 8, 10.1186/1476-069X-8-8 · DOI
  8. Stewart P., 1999, Environ. Res., 80, S87, 10.1006/enrs.1998.3905 · DOI
  9. Harada M., 1995, Crit. Rev. Toxicol., 25, 1, 10.3109/10408449509089885 · DOI · Paper page
  10. Aozasa O., 2008, Bull. Environ. Contam. Toxicol., 81, 578, 10.1007/s00128-008-9546-y · DOI
  11. Burse V. W., 2000, J. Expo. Anal. Environ. Epidemiol., 10, 776, 10.1038/sj.jea.7500125 · DOI
  12. Kawashiro Y., 2008, Endocrin. J., 55, 1071, 10.1507/endocrj.K08E-155 · DOI
  13. Miller R. K., 1988, Biological Monitoring of Toxic Metals, 567, 10.1007/978-1-4613-0961-1_28 · DOI
  14. Goyer R. A., 1991, Fundam. Appl. Toxicol., 16, 22, 10.1016/0272-0590(91)90130-V · DOI
  15. Lagerkvist B. I., 1996, Arch. Environ. Health, 51, 389, 10.1080/00039896.1996.9934427 · DOI
  16. Osman K., 2000, Clin. Biochem., 33, 131, 10.1016/S0009-9120(00)00052-7 · DOI · Paper page
  17. 1991, Chemical Contaminants in Human Milk
  18. Arendt M., 2008, Environ. Health, 7, S6, 10.1186/1476-069X-7-S1-S6 · DOI
  19. Aylward L. L., 2003, J. Toxicol. Environ. Health, A, 66, 1, 10.1080/15287390306460 · DOI
  20. DeKoning E. P., 2000, J. Expo. Anal. Environ. Epidemiol., 10, 285, 10.1038/sj.jea.7500090 · DOI
  21. Jacobson J. L., 1984, Am. J. Public Health, 74, 378, 10.2105/AJPH.74.4.378 · DOI
  22. Koopman-Esseboom C., 1996, Pediatrics, 97, 700, 10.1542/peds.97.5.700 · DOI · Paper page
  23. Muckle G., 2001, Environ. Health Perspect., 109, 1291
  24. Schecter A., 1998, Chemosphere, 37, 1817, 10.1016/S0045-6535(98)00247-1 · DOI
  25. Shen H., 2007, Chemosphere, 67, S256, 10.1016/j.chemosphere.2006.05.106 · DOI
  26. Wittsiepe J., 2007, Chemosphere, 67, S286, 10.1016/j.chemosphere.2006.05.118 · DOI
  27. Needham L. L., 2007, Int. J. Hyg. Environ. Health, 210, 229, 10.1016/j.ijheh.2006.11.002 · DOI
  28. Fangstrom B., 2005, Environ. Sci. Technol., 39, 9457, 10.1021/es0513032 · DOI
  29. Weihe P., 1996, Sci. Total Environ., 186, 141, 10.1016/0048-9697(96)05094-2 · DOI
  30. Heilmann C., 2010, Environ. Health Perspect., 118, 1434, 10.1289/ehp.1001975 · DOI
  31. Suzuki G., 2005, Biosci. Biotechnol. Biochem., 69, 1836, 10.1271/bbb.69.1836 · DOI
  32. Greizerstein H. B., 1999, Environ. Res., 80, 280, 10.1006/enrs.1999.3956 · DOI
  33. Eyster J. T., 1983, Arch. Environ. Health, 38, 47, 10.1080/00039896.1983.10543978 · DOI
  34. Guvenius D. M., 2003, Environ. Health Perspect., 111, 1235, 10.1289/ehp.5946 · DOI · Paper page
  35. Doucet J., 2009, Environ. Health Perspect., 117, 605, 10.1289/ehp.0800205 · DOI
  36. Monroy R., 2008, Environ. Res., 108, 56, 10.1016/j.envres.2008.06.001 · DOI · Paper page
  37. Karrman A., 2007, Environ. Health Perspect., 115, 226, 10.1289/ehp.9491 · DOI · Paper page
  38. Tao L., 2008, Environ. Sci. Technol., 42, 3096, 10.1021/es702789k · DOI
  39. Grandjean P., 2005, Environ. Health Perspect., 113, 905, 10.1289/ehp.7842 · DOI
  40. Schramel P., 1988, Biol. Trace Elem. Res., 15, 111, 10.1007/BF02990130 · DOI

Cited by

See all 406

Metadata

Authors
Needham, L. L., Grandjean, P., Heinzow, B., Jørgensen, P. J., Nielsen, F., Patterson, D. G., Sjödin, A., Turner, W. E., & Weihe, P.
Venue
Environmental Science & Technology
Publisher
American Chemical Society (ACS)
Published
2010-12-17
Volume
45
Issue
3
Pages
1121-1126
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
DOI
10.1021/es1019614
OpenAlex
W2163238434
Cited by
406
References
0
FWCI
13.77
Type
journal article
Language
en
Open access
hybrid
Licence
pubs.acs.org/page/policy/authorchoice_termsofuse.html (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues. https://app.cochat.ai/papers/10.1021/es1019614
The paper
Needham, L. L., Grandjean, P., Heinzow, B., Jørgensen, P. J., Nielsen, F., Patterson, D. G., Sjödin, A., Turner, W. E., & Weihe, P. (2011). Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues. Environmental Science & Technology. https://doi.org/10.1021/es1019614

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.