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Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues

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Needham, Larry L., Grandjean, Philippe, Heinzow, Birger, Jørgensen, Poul J., Nielsen, Flemming, Patterson, Donald G., Sjödin, Andreas, Turner, Wayman E., Weihe, Pal·2011·Environmental Science & Technology
DOI 10.1021/es1019614
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Abstract

Passage of environmental chemicals across the placenta has important toxicological consequences, as well as for choosing samples for analysis and for interpreting the results. To obtain systematic data, we collected in 2000 maternal and cord blood, cord tissue, placenta, and milk in connection with births in the Faroe Islands, where exposures to marine contaminants is increased. In 15 sample sets, we measured a total of 87 environmental chemicals, almost all of which were detected both in maternal and fetal tissues. The maternal serum lipid-based concentrations of organohalogen compounds averaged 1.7 times those of cord serum, 2.8 times those of cord tissue and placenta, and 0.7 those of milk. For organohalogen compounds detectable in all matrices, a high degree of correlation between concentrations in maternal serum and the other tissues investigated was generally observed (r(2) > 0.5). Greater degree of chlorination resulted in lower transfer from maternal serum into milk. Concentrations of pentachlorbenzene, γ-hexachlorocyclohexane, and several polychlorinated biphenyl congeners with low chlorination were higher in fetal samples and showed poor correlation with maternal levels. Perfluorinated compounds occurred in lower concentrations in cord serum than in maternal serum. Cadmium, lead, mercury, and selenium were all detected in fetal samples, but only mercury showed close correlations among concentrations in different matrices. Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform.

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Research works printed but not linked: 40

  1. Grandjean P., 2008, Basic Clin. Pharmacol. Toxicol., 102, 73, 10.1111/j.1742-7843.2007.00114.x · DOI
  2. Andersen H. R., 2000, Toxicology, 144, 121, 10.1016/S0300-483X(99)00198-5 · DOI
  3. Grandjean P., 1994, Clin. Chem., 40, 1360, 10.1093/clinchem/40.7.1360 · DOI
  4. Meijer L., 2008, Environ. Sci. Technol., 42, 3428, 10.1021/es702446p · DOI
  5. Nakamura T., 2008, Sci. Total Environ., 394, 39, 10.1016/j.scitotenv.2008.01.012 · DOI
  6. Rogan W. J., 1986, J. Pediatr., 109, 335, 10.1016/S0022-3476(86)80397-3 · DOI · Paper page
  7. Smolders R., 2009, Environ. Health, 8, 8, 10.1186/1476-069X-8-8 · DOI
  8. Stewart P., 1999, Environ. Res., 80, S87, 10.1006/enrs.1998.3905 · DOI
  9. Harada M., 1995, Crit. Rev. Toxicol., 25, 1, 10.3109/10408449509089885 · DOI · Paper page
  10. Aozasa O., 2008, Bull. Environ. Contam. Toxicol., 81, 578, 10.1007/s00128-008-9546-y · DOI
  11. Burse V. W., 2000, J. Expo. Anal. Environ. Epidemiol., 10, 776, 10.1038/sj.jea.7500125 · DOI
  12. Kawashiro Y., 2008, Endocrin. J., 55, 1071, 10.1507/endocrj.K08E-155 · DOI
  13. Miller R. K., 1988, Biological Monitoring of Toxic Metals, 567, 10.1007/978-1-4613-0961-1_28 · DOI
  14. Goyer R. A., 1991, Fundam. Appl. Toxicol., 16, 22, 10.1016/0272-0590(91)90130-V · DOI
  15. Lagerkvist B. I., 1996, Arch. Environ. Health, 51, 389, 10.1080/00039896.1996.9934427 · DOI
  16. Osman K., 2000, Clin. Biochem., 33, 131, 10.1016/S0009-9120(00)00052-7 · DOI · Paper page
  17. 1991, Chemical Contaminants in Human Milk
  18. Arendt M., 2008, Environ. Health, 7, S6, 10.1186/1476-069X-7-S1-S6 · DOI
  19. Aylward L. L., 2003, J. Toxicol. Environ. Health, A, 66, 1, 10.1080/15287390306460 · DOI
  20. DeKoning E. P., 2000, J. Expo. Anal. Environ. Epidemiol., 10, 285, 10.1038/sj.jea.7500090 · DOI
  21. Jacobson J. L., 1984, Am. J. Public Health, 74, 378, 10.2105/AJPH.74.4.378 · DOI
  22. Koopman-Esseboom C., 1996, Pediatrics, 97, 700, 10.1542/peds.97.5.700 · DOI · Paper page
  23. Muckle G., 2001, Environ. Health Perspect., 109, 1291
  24. Schecter A., 1998, Chemosphere, 37, 1817, 10.1016/S0045-6535(98)00247-1 · DOI
  25. Shen H., 2007, Chemosphere, 67, S256, 10.1016/j.chemosphere.2006.05.106 · DOI
  26. Wittsiepe J., 2007, Chemosphere, 67, S286, 10.1016/j.chemosphere.2006.05.118 · DOI
  27. Needham L. L., 2007, Int. J. Hyg. Environ. Health, 210, 229, 10.1016/j.ijheh.2006.11.002 · DOI
  28. Fangstrom B., 2005, Environ. Sci. Technol., 39, 9457, 10.1021/es0513032 · DOI
  29. Weihe P., 1996, Sci. Total Environ., 186, 141, 10.1016/0048-9697(96)05094-2 · DOI
  30. Heilmann C., 2010, Environ. Health Perspect., 118, 1434, 10.1289/ehp.1001975 · DOI
  31. Suzuki G., 2005, Biosci. Biotechnol. Biochem., 69, 1836, 10.1271/bbb.69.1836 · DOI
  32. Greizerstein H. B., 1999, Environ. Res., 80, 280, 10.1006/enrs.1999.3956 · DOI
  33. Eyster J. T., 1983, Arch. Environ. Health, 38, 47, 10.1080/00039896.1983.10543978 · DOI
  34. Guvenius D. M., 2003, Environ. Health Perspect., 111, 1235, 10.1289/ehp.5946 · DOI · Paper page
  35. Doucet J., 2009, Environ. Health Perspect., 117, 605, 10.1289/ehp.0800205 · DOI
  36. Monroy R., 2008, Environ. Res., 108, 56, 10.1016/j.envres.2008.06.001 · DOI · Paper page
  37. Karrman A., 2007, Environ. Health Perspect., 115, 226, 10.1289/ehp.9491 · DOI · Paper page
  38. Tao L., 2008, Environ. Sci. Technol., 42, 3096, 10.1021/es702789k · DOI
  39. Grandjean P., 2005, Environ. Health Perspect., 113, 905, 10.1289/ehp.7842 · DOI
  40. Schramel P., 1988, Biol. Trace Elem. Res., 15, 111, 10.1007/BF02990130 · DOI

Cited by

Metadata

Authors
Needham, L. L., Grandjean, P., Heinzow, B., Jørgensen, P. J., Nielsen, F., Patterson, D. G., Sjödin, A., Turner, W. E., & Weihe, P.
Venue
Environmental Science & Technology
Publisher
American Chemical Society (ACS)
Published
2010-12-17
Volume
45
Issue
3
Pages
1121-1126
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
DOI
10.1021/es1019614
OpenAlex
W2163238434
Cited by
406
References
0
FWCI
13.77
Type
journal article
Language
en
Open access
hybrid
Licence
pubs.acs.org/page/policy/authorchoice_termsofuse.html (vor)

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