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Occurrence and Toxicity of Disinfection Byproducts in European Drinking Waters in Relation with the HIWATE Epidemiology Study

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Jeong, Clara H., Wagner, Elizabeth D., Siebert, Vincent R., Anduri, Sridevi, Richardson, Susan D., Daiber, Eric J., McKague, A. Bruce, Kogevinas, Manolis, Villanueva, Cristina M., Goslan, Emma H., Luo, Wentai, Isabelle, Lorne M., Pankow, James F., Grazuleviciene, Regina, Cordier, Sylvaine, Edwards, Susan C., Righi, Elena, Nieuwenhuijsen, Mark J., Plewa, Michael J.·2012·Environmental Science & Technology
DOI 10.1021/es3024226
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Abstract

The HIWATE (Health Impacts of long-term exposure to disinfection byproducts in drinking WATEr) project was a systematic analysis that combined the epidemiology on adverse pregnancy outcomes and other health effects with long-term exposure to low levels of drinking water disinfection byproducts (DBPs) in the European Union. The present study focused on the relationship of the occurrence and concentration of DBPs with in vitro mammalian cell toxicity. Eleven drinking water samples were collected from five European countries. Each sampling location corresponded with an epidemiological study for the HIWATE program. Over 90 DBPs were identified; the range in the number of DBPs and their levels reflected the diverse collection sites, different disinfection processes, and the different characteristics of the source waters. For each sampling site, chronic mammalian cell cytotoxicity correlated highly with the numbers of DBPs identified and the levels of DBP chemical classes. Although there was a clear difference in the genotoxic responses among the drinking waters, these data did not correlate as well with the chemical analyses. Thus, the agents responsible for the genomic DNA damage observed in the HIWATE samples may be due to unresolved associations of combinations of identified DBPs, unknown emerging DBPs that were not identified, or other toxic water contaminants. This study represents the first to integrate quantitative in vitro toxicological data with analytical chemistry and human epidemiologic outcomes for drinking water DBPs.

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Metadata

Authors
Jeong, C. H., Wagner, E. D., Siebert, V. R., Anduri, S., Richardson, S. D., Daiber, E. J., McKague, A. B., Kogevinas, M., Villanueva, C. M., Goslan, E. H., Luo, W., Isabelle, L. M., Pankow, J. F., Grazuleviciene, R., Cordier, S., Edwards, S. C., Righi, E., Nieuwenhuijsen, M. J., & Plewa, M. J.
Venue
Environmental Science & Technology
Publisher
American Chemical Society (ACS)
Published
2012-10-11
Volume
46
Issue
21
Pages
12120-12128
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
DOI
10.1021/es3024226
OpenAlex
W2313751416
Cited by
182
References
5
FWCI
7.66
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Occurrence and Toxicity of Disinfection Byproducts in European Drinking Waters in Relation with the HIWATE Epidemiology Study. https://app.cochat.ai/papers/10.1021/es3024226
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Jeong, C. H., Wagner, E. D., Siebert, V. R., Anduri, S., Richardson, S. D., Daiber, E. J., McKague, A. B., Kogevinas, M., Villanueva, C. M., Goslan, E. H., Luo, W., Isabelle, L. M., Pankow, J. F., Grazuleviciene, R., Cordier, S., Edwards, S. C., Righi, E., Nieuwenhuijsen, M. J., & Plewa, M. J. (2012). Occurrence and Toxicity of Disinfection Byproducts in European Drinking Waters in Relation with the HIWATE Epidemiology Study. Environmental Science & Technology. https://doi.org/10.1021/es3024226

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