The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Partial Oxidation (“Aging”) and Surface Modification Decrease the Toxicity of Nanosized Zerovalent Iron
Abstract
Nanoscale zero-valent iron (nZVI) is a "redox"-active nanomaterial used in the remediation of contaminated groundwater. To assess the effect of "aging" and surface modification on its potential neurotoxicity, cultured rodent microglia (BV2) and neurons (N27) were exposed to fresh nZVI, "aged" (>11 months) nZVI, magnetite, and polyaspartate surface-modified (SM) nZVI. Increases in various measures of oxidative stress indicated that BV2 microglia responded to these materials in the following rank order: nZVI > "aged" nZVI > magnetite = SM nZVI. Fresh nZVI produced morphological evidence of mitochondrial swelling and apoptosis. In N27 neurons, ATP levels were reduced in the following rank order: nZVI > SM-nZVI > "aged" nZVI = magnetite. Ultrastructurally, nZVI produced a perinuclear floccular material and cytoplasmic granularity. Both SM-nZVI produced intracellular deposits of nanosize particles in the N27. The physicochemical properties of each material, measured under exposure conditions, indicated that all had electronegative zeta potentials. The iron content of nZVI (approximately 35%) and SM-nZVI (approximately 25%) indicated high "redox" activity while that of "aged" and magnetite was neglibile. Sedimentation and agglomeration occurred in the following rank order: nZV > "aged" nZVI > magnetite >> SM-nZVI. Correlating these properties with toxicity indicated that partial or complete oxidation of nZVI reduced its "redox" activity, agglomeration, sedimentation rate, and toxicity to mammalian cells. Surface modification decreased nZVI toxicity by reducing sedimentation which limited particle exposure to the cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,760
Chithrani, B. D., & Chan, W. C. W. (2007) · Nano Letters · doi:10.1021/nl070363y · Cited by 2,286
In vitro toxicity of nanoparticles in BRL 3A rat liver cells
Hussain, S. M., Hess, K. L., Gearhart, J. M., Geiss, K. T., & Schlager, J. J. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.06.034 · Cited by 2,025
Nanoscale iron particles for environmental remediation: An overview
Zhang, W.-X. (2003) · Journal of Nanoparticle Research · doi:10.1023/a:1025520116015 · Cited by 2,003
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557
Pathways of clathrin-independent endocytosis
Mayor, S., & Pagano, R. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2216 · Cited by 1,556
Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions
Adams, L. K., Lyon, D. Y., & Alvarez, P. J. J. (2006) · Water Research · doi:10.1016/j.watres.2006.08.004 · Cited by 1,543
Remediation of Cr(VI) and Pb(II) Aqueous Solutions Using Supported, Nanoscale Zero-valent Iron
Ponder, S. M., Darab, J. G., & Mallouk, T. E. (2000) · Environmental Science & Technology · doi:10.1021/es9911420 · Cited by 1,209
Assessing the Risks of Manufactured Nanomaterials
Wiesner, M. R., Lowry, G. V., Alvarez, P., Dionysiou, D., & Biswas, P. (2006) · Environmental Science & Technology · doi:10.1021/es062726m · Cited by 1,160
Self-citationAggregation and Sedimentation of Aqueous Nanoscale Zerovalent Iron Dispersions
Phenrat, T., Saleh, N., Sirk, K., Tilton, R. D., & Lowry, G. V. (2007) · Environmental Science & Technology · doi:10.1021/es061349a · Cited by 1,084
Self-citationNurmi, J. T., Tratnyek, P. G., Sarathy, V., Baer, D. R., Amonette, J. E., Pecher, K., Wang, C., Linehan, J. C., Matson, D. W., Penn, R. L., et al. (2005) · Environmental Science & Technology · doi:10.1021/es049190u · Cited by 955
Limbach, L. K., Wick, P., Manser, P., Grass, R. N., Bruinink, A., & Stark, W. J. (2007) · Environmental Science & Technology · doi:10.1021/es062629t · Cited by 889
Long, T. C., Saleh, N., Tilton, R. D., Lowry, G. V., & Veronesi, B. (2006) · Environmental Science & Technology · doi:10.1021/es060589n · Cited by 870
Self-citationKreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdörster, G., & Ziesenis, A. (2002) · Journal of Toxicology and Environmental Health, Part A · doi:10.1080/00984100290071649 · Cited by 790
Liu, Y., Majetich, S. A., Tilton, R. D., Sholl, D. S., & Lowry, G. V. (2005) · Environmental Science & Technology · doi:10.1021/es049195r · Cited by 784
Self-citationLimbach, L. K., Li, Y., Grass, R. N., Brunner, T. J., Hintermann, M. A., Muller, M., Gunther, D., & Stark, W. J. (2005) · Environmental Science & Technology · doi:10.1021/es051043o · Cited by 779
Bactericidal Effect of Zero-Valent Iron Nanoparticles on Escherichia coli
Lee, C., Kim, J. Y., Lee, W. I., Nelson, K. L., Yoon, J., & Sedlak, D. L. (2008) · Environmental Science & Technology · doi:10.1021/es800408u · Cited by 766
Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability
Lockman, P. R., Koziara, J. M., Mumper, R. J., & Allen, D. D. (2004) · Journal of Drug Targeting · doi:10.1080/10611860400015936 · Cited by 742
He, F., Zhao, D., Liu, J., & Roberts, C. B. (2007) · Industrial & Engineering Chemistry Research · doi:10.1021/ie0610896 · Cited by 663
Polymer Architecture and Drug Delivery
Qiu, L. Y., & Bae, Y. H. (2006) · Pharmaceutical Research · doi:10.1007/s11095-005-9046-2 · Cited by 604
He, F., & Zhao, D. (2007) · Environmental Science & Technology · doi:10.1021/es0705543 · Cited by 591
Targeting of nanoparticles to the clathrin-mediated endocytic pathway
Harush-Frenkel, O., Debotton, N., Benita, S., & Altschuler, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.11.135 · Cited by 564
Delivery Vehicles for Zerovalent Metal Nanoparticles in Soil and Groundwater
Schrick, B., Hydutsky, B. W., Blough, J. L., & Mallouk, T. E. (2004) · Chemistry of Materials · doi:10.1021/cm0218108 · Cited by 548
Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage
Tabata, Y., & Ikada, Y. (1988) · Biomaterials · doi:10.1016/0142-9612(88)90033-6 · Cited by 538
Saleh, N., Kim, H.-J., Phenrat, T., Matyjaszewski, K., Tilton, R. D., & Lowry, G. V. (2008) · Environmental Science & Technology · doi:10.1021/es071936b · Cited by 529
Self-citationPhenrat, T., Saleh, N., Sirk, K., Kim, H.-J., Tilton, R. D., & Lowry, G. V. (2008) · Journal of Nanoparticle Research · doi:10.1007/s11051-007-9315-6 · Cited by 518
Self-citationLiu, Y., & Lowry, G. V. (2006) · Environmental Science & Technology · doi:10.1021/es060685o · Cited by 471
Self-citationIron Nanoparticles: the Core−Shell Structure and Unique Properties for Ni(II) Sequestration
Li, X.-Q., & Zhang, W.-X. (2006) · Langmuir · doi:10.1021/la060057k · Cited by 455
Long, T. C., Tajuba, J., Sama, P., Saleh, N., Swartz, C., Parker, J., Hester, S., Lowry, G. V., & Veronesi, B. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10216 · Cited by 452
Self-citationSurface Modifications Enhance Nanoiron Transport and NAPL Targeting in Saturated Porous Media
Saleh, N., Sirk, K., Liu, Y., Phenrat, T., Dufour, B., Matyjaszewski, K., Tilton, R. D., & Lowry, G. V. (2007) · Environmental Engineering Science · doi:10.1089/ees.2007.24.45 · Cited by 448
Self-citationOxidative Degradation of the Carbothioate Herbicide, Molinate, Using Nanoscale Zero-Valent Iron
Joo, S. H., Feitz, A. J., & Waite, T. D. (2004) · Environmental Science & Technology · doi:10.1021/es035157g · Cited by 398
Hoch, L. B., Mack, E. J., Hydutsky, B. W., Hershman, J. M., Skluzacek, J. M., & Mallouk, T. E. (2008) · Environmental Science & Technology · doi:10.1021/es702589u · Cited by 384
Powers, K. W., Palazuelos, M., Moudgil, B. M., & Roberts, S. M. (2007) · Nanotoxicology · doi:10.1080/17435390701314902 · Cited by 383
Lowry, G. V., & Johnson, K. M. (2004) · Environmental Science & Technology · doi:10.1021/es049835q · Cited by 362
Self-citationImpact of Fullerene (C60) on a Soil Microbial Community
Tong, Z., Bischoff, M., Nies, L., Applegate, B., & Turco, R. F. (2007) · Environmental Science & Technology · doi:10.1021/es061953l · Cited by 345
Karlsson, H. L., Nilsson, L., & Möller, L. (2005) · Chemical Research in Toxicology · doi:10.1021/tx049723c · Cited by 337
Adsorbed Triblock Copolymers Deliver Reactive Iron Nanoparticles to the Oil/Water Interface
Saleh, N., Phenrat, T., Sirk, K., Dufour, B., Ok, J., Sarbu, T., Matyjaszewski, K., Tilton, R. D., & Lowry, G. V. (2005) · Nano Letters · doi:10.1021/nl0518268 · Cited by 319
Self-citationROLE of MITOCHONDRIA in TOXIC OXIDATIVE STRESS
Fariss, M. W. (2005) · Molecular Interventions · doi:10.1124/mi.5.2.7 · Cited by 286
Antibacterial Activity of Fullerene Water Suspensions (nC60) Is Not Due to ROS-Mediated Damage
Lyon, D. Y., Brunet, L., Hinkal, G. W., Wiesner, M. R., & Alvarez, P. J. J. (2008) · Nano Letters · doi:10.1021/nl0726398 · Cited by 266
Trichloroethene Hydrodechlorination in Water by Highly Disordered Monometallic Nanoiron
Liu, Y., Choi, H., Dionysiou, D., & Lowry, G. V. (2005) · Chemistry of Materials · doi:10.1021/cm0511217 · Cited by 217
Self-citationKanel, S. R., Goswami, R. R., Clement, T. P., Barnett, M. O., & Zhao, D. (2008) · Environmental Science & Technology · doi:10.1021/es071774j · Cited by 207
Zhou, W., Hurlbert, M. S., Schaack, J., Prasad, K. N., & Freed, C. R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02215-0 · Cited by 204
Arimura, H., Ohya, Y., & Ouchi, T. (2005) · Biomacromolecules · doi:10.1021/bm0494491 · Cited by 146
Utilization of nanoscale zero‐valent iron for source remediation—A case study
Henn, K., & Waddill, D. W. (2006) · Remediation Journal · doi:10.1002/rem.20081 · Cited by 142
Veronesi, B., Makwana, O., Pooler, M., & Chen, L. (2005) · Inhalation Toxicology · doi:10.1080/08958370590912888 · Cited by 131
Self-citationChiueh, C. C., & Rauhala, P. V. (1999) · Free Radical Research · doi:10.1080/10715769900301211 · Cited by 115
Chang, R. C., Rota, C., Glover, R. E., Mason, R. P., & Hong, J. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02267-2 · Cited by 73
Sama, P., Long, T. C., Hester, S., Tajuba, J., Parker, J., Chen, L., & Veronesi, B. (2007) · Inhalation Toxicology · doi:10.1080/08958370701628721 · Cited by 71
Self-citationKang, J., Yang, M.-S., Jou, I., & Joe, E.-H. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01515-4 · Cited by 27
Shafer, L. L., McNulty, J. A., & Young, M. R. (2002) · NeuroImmunoModulation · doi:10.1159/000069972 · Cited by 15
Cited by
Nanoparticle Aggregation: Challenges to Understanding Transport and Reactivity in the Environment
Hotze, E. M., Phenrat, T., & Lowry, G. V. (2010) · Journal of Environmental Quality · doi:10.2134/jeq2009.0462 · Cited by 1,257
Self-citationNanoscale zero-valent iron: Future prospects for an emerging water treatment technology
Crane, R. A., & Scott, T. B. (2012) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2011.11.073 · Cited by 1,154
Guan, X., Sun, Y., Qin, H., Li, J., Lo, I. M. C., He, D., & Dong, H. (2015) · Water Research · doi:10.1016/j.watres.2015.02.034 · Cited by 962
Review on nano zerovalent iron (nZVI): From synthesis to environmental applications
Stefaniuk, M., Oleszczuk, P., & Ok, Y. S. (2016) · Chemical Engineering Journal · doi:10.1016/j.cej.2015.11.046 · Cited by 935
Magnetic nanoparticles: Essential factors for sustainable environmental applications
Tang, S. C. N., & Lo, I. M. C. (2013) · Water Research · doi:10.1016/j.watres.2013.02.039 · Cited by 891
Metadata
- Authors
- Phenrat, T., Long, T. C., Lowry, G. V., & Veronesi, B.
- Venue
- Environmental Science & Technology
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-11-26
- Volume
- 43
- Issue
- 1
- Pages
- 195-200
- ISSN
- 0013-936X (ISSN-L)
- 1520-5851
- OpenAlex
- W2041742565
- Cited by
- 321
- References
- 52
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
