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Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells

Zhou, Wenbo, Hurlbert, Marc S., Schaack, Jerome, Prasad, Kedar N., Freed, Curt R.·2000·Brain Research
DOI 10.1016/s0006-8993(00)02215-0
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Research works printed but not linked: 41

  1. Adams, 1996, Characterization and transplantation of two neuronal cell lines with dopaminergic properties, Neurochem. Res., 21, 619, 10.1007/BF02527762 · doi:10.1007/bf02527762
  2. Athanassiadou, 1999, Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding α-synuclein, Am. J. Hum. Genet., 65, 555, 10.1086/302486 · DOI
  3. Baba, 1998, Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies, Am. J. Pathol., 152, 879
  4. Clarkson, 1999, In vitro sensitivity of undifferentiated and differentiated immortalized dopamine neurons to neurotoxins is modified by glial cell line-derived neurotrophic factor (GDNF), Proc. Soc. Exp. Biol. Med., 222, 157, 10.1046/j.1525-1373.1999.d01-126.x · DOI
  5. Clarkson, 1998, Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells, Proc. Natl. Acad. Sci. U.S.A., 95, 1265, 10.1073/pnas.95.3.1265 · doi:10.1073/pnas.95.3.1265
  6. Clayton, 1998, The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease, Trends Neurosci., 21, 249, 10.1016/S0166-2236(97)01213-7 · DOI · Paper page
  7. Conway, 1998, Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease, Nat. Med., 4, 1318, 10.1038/3311 · DOI · Paper page
  8. El-Agnaf, 1998, Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments, FEBS Lett., 440, 71, 10.1016/S0014-5793(98)01418-5 · DOI · Paper page
  9. El-Agnaf, 1998, Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson’s disease, FEBS Lett., 440, 67, 10.1016/S0014-5793(98)01419-7 · DOI · Paper page
  10. Engelender, 1999, Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions, Nat. Genet., 22, 110, 10.1038/8820 · DOI · Paper page
  11. Fagan, 1999, Adenovirus-mediated expression of an olfactory cyclic nucleotide-gated channel regulates the endogenous Ca2+-inhibitable adenylyl cyclase in C6-2B glioma cells, J. Biol. Chem., 274, 12445, 10.1074/jbc.274.18.12445 · DOI
  12. George, 1995, Characterization of a novel protein regulated during the critical period for song learning in the zebra finch, Neuron, 15, 361, 10.1016/0896-6273(95)90040-3 · DOI · Paper page
  13. Giasson, 1999, Mutant and wild type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro, J. Biol. Chem., 274, 7619, 10.1074/jbc.274.12.7619 · DOI · Paper page
  14. Gibb, 1989, Neuropathology in movement disorders, J. Neurol. Neurosurg. Psychiatry, Suppl., 52, 55, 10.1136/jnnp.52.Suppl.55 · DOI
  15. Glinka, 1997, Mechanism of 6-hydroxydopamine neurotoxicity, J. Neural Transm., Suppl, 50, 55, 10.1007/978-3-7091-6842-4_7 · DOI · Paper page
  16. Gomez-Foix, 1992, Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hapatocytes confers altered regulation of glycogen metabolism, J. Biol. Chem., 267, 25129, 10.1016/S0021-9258(19)74015-0 · DOI · Paper page
  17. Graham, 1977, Characteristics of a human cell line transformed by DNA from human adenovirus type 5, J. Gen. Virol., 36, 59, 10.1099/0022-1317-36-1-59 · DOI · Paper page
  18. Graham, 1995, Methods for construction of adenovirus vectors, Mol. Biotechnol., 3, 207, 10.1007/BF02789331 · DOI · Paper page
  19. Hashimoto, 1998, Human recombinant NACP/α-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease, Brain Res., 799, 301, 10.1016/S0006-8993(98)00514-9 · DOI · Paper page
  20. Hashimoto, 1999, Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro, Neuroreport, 10, 717, 10.1097/00001756-199903170-00011 · DOI · Paper page
  21. Hsu, 1998, Expression pattern of synucleins (non-Aβ component of Alzheimer’s disease amyloid precursor protein/α-synuclein) during murine brain development, J. Neurochem., 71, 338, 10.1046/j.1471-4159.1998.71010338.x · DOI · Paper page
  22. Irizarry, 1998, Nigra and cortical Lewy bodies and dystrophic nigral neurites in Parkinson’s disease and cortical Lewy body disease contain α-synuclein immunoreactivity, J. Neuropathol. Exp. Neurol., 57, 334, 10.1097/00005072-199804000-00005 · DOI · Paper page
  23. Jensen, 1997, Binding of Aβ to α- and β-synucleins: identification of segments in α-synuclein/NAC precursor that binds Aβ and NAC, Biochem. J., 323, 539, 10.1042/bj3230539 · DOI
  24. Langston, 1998, Epidemiology verus genetics in Parkinson’s disease: progress in resolving an age-old debate, Ann. Neurol., 44, 45, 10.1002/ana.410440707 · DOI · Paper page
  25. Lewy, 1913, Zur pathologischen Anatomie der Paralysis agitans, Dtsch Z. Nervenheilk, 50, 50
  26. Mezey, 1998, Alpha synuclein in neurodegenerative disorders: Murderer or accomplice, Nat. Med., 4, 755, 10.1038/nm0798-755 · DOI · Paper page
  27. Michel, 1990, Toxicity of 6-hydroxydopamine and dopamine for dopaminergic neurons in culture, J. Neurosci. Res., 26, 428, 10.1002/jnr.490260405 · DOI · Paper page
  28. Narhi, 1999, Both familial Parkinson’s disease mutations accelerate alpha-synuclein aggregation, J. Biol. Chem., 274, 9843, 10.1074/jbc.274.14.9843 · DOI · Paper page
  29. Ostrerova, 1999, α-Synuclein shares physical and functional homology with 14-3-3 proteins, J. Neurosci., 19, 5782, 10.1523/JNEUROSCI.19-14-05782.1999 · DOI · Paper page
  30. Paik, 1998, Self-oligomerization of NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer’s disease amyloid, observed in the presence of a C-terminal Aβ fragment (residues 25–35), FEBS Lett., 421, 73, 10.1016/S0014-5793(97)01537-8 · DOI
  31. Paik, 1999, Copper (II)-induced self-oligomerization of α-synuclein, Biochem. J., 340, 821, 10.1042/bj3400821 · doi:10.1042/bj3400821 · Paper page
  32. Papadimitriou, 1999, Mutated α-synuclein gene in two Greek kindreds with familial PD: Incomplete penetrance, Neurology, 52, 651, 10.1212/WNL.52.3.651 · DOI
  33. Petersen, 1999, Developmental expression of α-synuclein in rat hippocampus and cerebral cortex, Neuroscience, 91, 651, 10.1016/S0306-4522(98)00596-X · DOI
  34. Riess, 1999, Parkinson’s disease – a multifactorial neurodegenerative disorder, J. Neural. Transm., Suppl, 56, 113, 10.1007/978-3-7091-6360-3_6 · DOI
  35. Schaack, 1995, Efficient selection of recombinant adenoviruses by vectors that express β-galactosidase, J. Virol., 69, 3920, 10.1128/JVI.69.6.3920-3923.1995 · DOI
  36. Spillantini, 1998, α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodies, Proc. Natl. Acad. Sci. U.S.A., 95, 6469, 10.1073/pnas.95.11.6469 · DOI · Paper page
  37. Ueda, 1993, Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer’s disease, Proc. Natl. Acad. Sci. U.S.A., 90, 11282, 10.1073/pnas.90.23.11282 · DOI · Paper page
  38. Weinreb, 1996, NACP, a protein implicated in Alzheimer’s disease and learning, is natively unfolded, Biochemistry, 35, 13709, 10.1021/bi961799n · DOI · Paper page
  39. Wood, 1999, alpha-Synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson’s disease, J. Biol. Chem., 274, 19509, 10.1074/jbc.274.28.19509 · DOI · Paper page
  40. Yoshimoto, 1995, NACP, the precursor protein of the non-amyloid β/A4 protein (Aβ) component of Alzheimer’s disease amyloid, binds Aβ and stimulates Aβ aggregatation, Proc. Natl. Acad. Sci. U.S.A., 92, 9141, 10.1073/pnas.92.20.9141 · DOI · Paper page
  41. Zawada, 1996, Growth factors rescue embryonic dopamine neurons from programmed cell death, Exp. Neurol., 140, 60, 10.1006/exnr.1996.0115 · DOI

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Metadata

Authors
Zhou, W., Hurlbert, M. S., Schaack, J., Prasad, K. N., & Freed, C. R.
Venue
Brain Research
Publisher
Elsevier BV
Published
2000-06
Volume
866
Issue
1-2
Pages
33-43
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/s0006-8993(00)02215-0
OpenAlex
W2030748454
Cited by
204
References
6
FWCI
12.38
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. https://app.cochat.ai/papers/10.1016/s0006-8993(00)02215-0
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Zhou, W., Hurlbert, M. S., Schaack, J., Prasad, K. N., & Freed, C. R. (2000). Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain Research. https://doi.org/10.1016/s0006-8993(00)02215-0

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