The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Active Oxygen Species Generated from Photoexcited Fullerene (C60) as Potential Medicines: O2-•versus1O2
Abstract
To characterize fullerenes (C(60) and C(70)) as photosensitizers in biological systems, the generation of active oxygen species, through energy transfer (singlet oxygen (1)O(2)) and electron transfer (reduced active oxygen radicals such as superoxide anion radical O(2)(-)* and hydroxyl radical *OH), was studied by a combination of methods, including biochemical (DNA-cleavage assay in the presence of various scavengers of active oxygen species), physicochemical (EPR radical trapping and near-infrared spectrometry), and chemical methods (nitro blue tetrazolium (NBT) method). Whereas (1)O(2) was generated effectively by photoexcited C(60) in nonpolar solvents such as benzene and benzonitrile, we found that O(2)(-)* and *OH were produced instead of (1)O(2) in polar solvents such as water, especially in the presence of a physiological concentration of reductants including NADH. The above results, together with those of a DNA cleavage assay in the presence of various scavengers of specific active oxygen species, indicate that the active oxygen species primarily responsible for photoinduced DNA cleavage by C(60) under physiological conditions are reduced species such as O(2)(-)* and *OH.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nanobelts of Semiconducting Oxides
Pan, Z. W., Dai, Z. R., & Wang, Z. L. (2001) · Science · doi:10.1126/science.1058120 · Cited by 5,823
Photophysical properties of sixty atom carbon molecule (C60)
Arbogast, J. W., Darmanyan, A. P., Foote, C. S., Diederich, F. N., Whetten, R. L., Rubin, Y., Alvarez, M. M., & Anz, S. J. (1991) · The Journal of Physical Chemistry · doi:10.1021/j100154a006 · Cited by 1,214
Friedman, S. H., DeCamp, D. L., Sijbesma, R. P., Srdanov, G., Wudl, F., & Kenyon, G. L. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00068a005 · Cited by 954
Photoinduced biochemical activity of fullerene carboxylic acid
Tokuyama, H., Yamago, S., Nakamura, E., Shiraki, T., & Sugiura, Y. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00070a064 · Cited by 619
Photophysical properties of C70
Arbogast, J. W., & Foote, C. S. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00023a041 · Cited by 476
Oxidative damage to DNA: Formation, measurement, and biological significance
Cadet, J., Berger, M., Douki, T., & Ravanat, J. L. (1997) · Reviews of Physiology Biochemistry and Pharmacology, Volume 131 · doi:10.1007/3-540-61992-5_5 · Cited by 432
Electron transfer to triplet fullerene C60
Arbogast, J. W., Foote, C. S., & Kao, M. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00032a063 · Cited by 426
Linkage and Solvent Dependence of Photoinduced Electron Transfer in Zincporphyrin-C60 Dyads
Imahori, H., Hagiwara, K., Aoki, M., Akiyama, T., Taniguchi, S., Okada, T., Shirakawa, M., & Sakata, Y. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9628415 · Cited by 395
Energy and Photoinduced Electron Transfer in Porphyrin−Fullerene Dyads
Kuciauskas, D., Lin, S., Seely, G. R., Moore, A. L., Moore, T. A., Gust, D., Drovetskaya, T., Reed, C. A., & Boyd, P. D. W. (1996) · The Journal of Physical Chemistry · doi:10.1021/jp9612745 · Cited by 341
Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo
Tsuchiya, T., Oguri, I., Yamakoshi, Y. N., & Miyata, N. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00812-5 · Cited by 226
Self-citation
Cited by
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
Oberdörster, G., Oberdörster, E., & Oberdörster, J. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7339 · Cited by 7,891
Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., et al. (2005) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-2-8 · Cited by 2,134
Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging
Parveen, S., Misra, R., & Sahoo, S. K. (2012) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2011.05.016 · Cited by 1,436
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
The Toxic Effects and Mechanisms of CuO and ZnO Nanoparticles
Chang, Y.-N., Zhang, M., Xia, L., Zhang, J., & Xing, G. (2012) · Materials · doi:10.3390/ma5122850 · Cited by 772
Nanotechnology Safety Concerns Revisited
Stern, S. T., & McNeil, S. E. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfm169 · Cited by 560
Cellular responses to nanoparticles: Target structures and mechanisms
Unfried, K., Albrecht, C., Klotz, L.-O., Von Mikecz, A., Grether-Beck, S., & Schins, R. P. F. (2007) · Nanotoxicology · doi:10.1080/00222930701314932 · Cited by 503
Brunet, L., Lyon, D. Y., Hotze, E. M., Alvarez, P. J. J., & Wiesner, M. R. (2009) · Environmental Science & Technology · doi:10.1021/es803093t · Cited by 469
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
Yin, J.-J., Lao, F., Fu, P. P., Wamer, W. G., Zhao, Y., Wang, P. C., Qiu, Y., Sun, B., Xing, G., Dong, J., et al. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.061 · Cited by 448
Graphene quantum dots as autophagy-inducing photodynamic agents
Markovic, Z. M., Ristic, B. Z., Arsikin, K. M., Klisic, D. G., Harhaji-Trajkovic, L. M., Todorovic-Markovic, B. M., Kepic, D. P., Kravic-Stevovic, T. K., Jovanovic, S. P., Milenkovic, M. M., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.060 · Cited by 441
Zhu, S., Oberdörster, E., & Haasch, M. L. (2006) · Marine Environmental Research · doi:10.1016/j.marenvres.2006.04.059 · Cited by 417
Nanomaterials and singlet oxygen photosensitizers: potential applications in photodynamic therapy
Wang, S., Gao, R., Zhou, F., & Selke, M. (2004) · Journal of Materials Chemistry · doi:10.1039/b311429e · Cited by 384
Photosensitizers in antibacterial photodynamic therapy: an overview
Ghorbani, J., Rahban, D., Aghamiri, S., Teymouri, A., & Bahador, A. (2018) · LASER THERAPY · doi:10.5978/islsm.27_18-ra-01 · Cited by 365
Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials
Hong, E. J., Choi, D. G., & Shim, M. S. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.01.007 · Cited by 361
Qin, Y., Li, G., Gao, Y., Zhang, L., Ok, Y. S., & An, T. (2018) · Water Research · doi:10.1016/j.watres.2018.03.012 · Cited by 339
Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers
Tegos, G. P., Demidova, T. N., Arcila-Lopez, D., Lee, H., Wharton, T., Gali, H., & Hamblin, M. R. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.08.014 · Cited by 272
Fate of micelles and quantum dots in cells
Maysinger, D., Lovrić, J., Eisenberg, A., & Savić, R. (2007) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2006.08.011 · Cited by 160
Lacombe, S., & Pigot, T. (2016) · Catalysis Science & Technology · doi:10.1039/c5cy01929j · Cited by 82
DNA Cleavage by UVA Irradiation of NADH with Dioxygen via Radical Chain Processes
Tanaka, M., Ohkubo, K., & Fukuzumi, S. (2006) · The Journal of Physical Chemistry A · doi:10.1021/jp064130r · Cited by 45
Metadata
- Authors
- Yamakoshi, Y., Umezawa, N., Ryu, A., Arakane, K., Miyata, N., Goda, Y., Masumizu, T., & Nagano, T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-09-24
- Volume
- 125
- Issue
- 42
- Pages
- 12803-12809
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1977192897
- Cited by
- 696
- References
- 29
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
