Cited by 160Nanoparticle-Based Drug DeliveryQuantum Dots Synthesis And PropertiesRNA Interference and Gene Delivery

Fate of micelles and quantum dots in cells

Maysinger, Dusica, Lovrić, Jasmina, Eisenberg, Adi, Savić, Radoslav·2007·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

Micelles and quantum dots have been used as experimental drug delivery systems and imaging tools both in vitro and in vivo. Investigations of their fate at the subcellular level require different surface-core modifications. Among the most common modifications are those with fluorescent probes, dense-core metals or radionucleids. Cellular fate of several fluorescent probes incorporated into poly(caprolactone)-b-copolymer micelles (PCL-b-PEO) was followed by confocal microscopy, and colloidal gold incorporated in poly 4-vinyl pyridine-PEO micelles were developed to explore micelle fate by electron microscopy. More recently, we have examined quantum dots (QDs) as the next-generation-labels for cells and nanoparticulate drug carriers amenable both to confocal and electron microscopic analyses. Effects of QDs at the cellular and subcellular levels and their integrity were studied. Results from different studies suggest that size, charge and surface manipulations of QDs may play a role in their subcellular distribution. Examples of pharmacological agents incorporated into block copolymer micelles, administered or attached to QD surfaces show how the final biological outcome (e.g. cell death, proliferation or differentiation) depends on physical properties of these nanoparticles.

Integrity signals

Registry

Crossref · 10.1016/j.ejpb.2006.08.011

Cites

136 of 136 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Maysinger, D., Lovrić, J., Eisenberg, A., & Savić, R.
Affiliations
  • University of Zagreb (HR)
  • McGill University (CA)
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2007-03
Volume
65
Issue
3
Pages
270-281
ISSN
0939-6411 (ISSN-L)
OpenAlex
W1964960898
Cited by
160
References
136
Citations by year
2025: 4 · 2024: 7 · 2023: 8 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 12 · 2012: 14
FWCI
0.86
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
micelles, quantum dots, subcellular localization, block copolymer micelles, gold nanoparticles, fluorescent probes, radionuclides, nanoparticle surface modification, nanoparticle drug carriers, cell death, cell proliferation, cell differentiation
MeSH terms
Animals, Cell Membrane, Cells, Cultured, Drug Carriers, Endocytosis, Ethylene Oxide, Fluorescent Dyes, Humans, Lactones, Micelles, Microscopy, Electron, Polyvinyls, Staining and Labeling, Cell Death, Reactive Oxygen Species, Gold Colloid, Oxidative Stress, Microscopy, Confocal, Fluorescence Resonance Energy Transfer, Quantum Dots

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review