The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Enhancing the Stability and Biological Functionalities of Quantum Dots via Compact Multifunctional Ligands
Abstract
We have designed and synthesized a series of modular ligands based on poly(ethylene glycol) (PEG) coupled with functional terminal groups to promote water-solubility and biocompatibility of quantum dots (QDs). Each ligand is comprised of three modules: a PEG single chain to promote hydrophilicity, a dihydrolipoic acid (DHLA) unit connected to one end of the PEG chain for strong anchoring onto the QD surface, and a potential biological functional group (biotin, carboxyl, and amine) at the other end of the PEG. Water-soluble QDs capped with these functional ligands were prepared via cap exchange with the native hydrophobic caps. Homogeneous QD solutions that are stable over extended periods of time and over a broad pH range were prepared. Surface binding assays and cellular internalization and imaging showed that QDs capped with DHLA-PEG-biotin strongly interacted with either NeutrAvidin immobilized on surfaces or streptavidin coupled to proteins which were subsequently taken up by live cells. EDC coupling in aqueous buffer solutions was also demonstrated using resonance energy transfer between DHLA-PEG-COOH-functionalized QDs and an amine-terminated dye. The new functional surface ligands described here provide not only stable and highly water-soluble QDs but also simple and easy access to various biological entities.
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Cites
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Self-citationSynthesis and Characterization of Monodisperse Nanocrystals and Close-Packed Nanocrystal Assemblies
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Self-citationIn Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
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Self-Assembly of CdSe−ZnS Quantum Dot Bioconjugates Using an Engineered Recombinant Protein
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Cited by
Grabolle, M., Spieles, M., Lesnyak, V., Gaponik, N., Eychmüller, A., & Resch-Genger, U. (2009) · Analytical Chemistry · doi:10.1021/ac900308v · Cited by 630
Functionalization of Inorganic Nanoparticles for Bioimaging Applications
Erathodiyil, N., & Ying, J. Y. (2011) · Accounts of Chemical Research · doi:10.1021/ar2000327 · Cited by 622
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Self-citationOh, E., Delehanty, J. B., Sapsford, K. E., Susumu, K., Goswami, R., Blanco-Canosa, J. B., Dawson, P. E., Granek, J., Shoff, M., Zhang, Q., et al. (2011) · ACS Nano · doi:10.1021/nn201624c · Cited by 425
Self-citationMonovalent, reduced-size quantum dots for imaging receptors on living cells
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Probing cellular events, one quantum dot at a time
Pinaud, F., Clarke, S., Sittner, A., & Dahan, M. (2010) · Nature Methods · doi:10.1038/nmeth.1444 · Cited by 401
Susumu, K., Oh, E., Delehanty, J. B., Blanco-Canosa, J. B., Johnson, B. J., Jain, V., Hervey, W. J., Algar, W. R., Boeneman, K., Dawson, P. E., et al. (2011) · Journal of the American Chemical Society · doi:10.1021/ja201919s · Cited by 293
Self-citationLiu, W., Greytak, A. B., Lee, J., Wong, C. R., Park, J., Marshall, L. F., Jiang, W., Curtin, P. N., Ting, A. Y., Nocera, D. G., et al. (2010) · Journal of the American Chemical Society · doi:10.1021/ja908137d · Cited by 278
Colloidal Nanocrystal-Based Gels and Aerogels: Material Aspects and Application Perspectives
Gaponik, N., Herrmann, A.-K., & Eychmüller, A. (2012) · The Journal of Physical Chemistry Letters · doi:10.1021/jz201357r · Cited by 173
Nag, O. K., Stewart, M. H., Deschamps, J. R., Susumu, K., Oh, E., Tsytsarev, V., Tang, Q., Efros, A. L., Vaxenburg, R., Black, B. J., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00954 · Cited by 80
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Metadata
- Authors
- Susumu, K., Uyeda, H. T., Medintz, I. L., Pons, T., Delehanty, J. B., & Mattoussi, H.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-10-23
- Volume
- 129
- Issue
- 45
- Pages
- 13987-13996
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2034753500
- Cited by
- 517
- References
- 28
- FWCI
- 22.12
- Type
- journal article
- Language
- en
- Open access
- closed
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