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Surface-Functionalizable Polymer Nanogels with Facile Hydrophobic Guest Encapsulation Capabilities
Open accessAbstract
The stability of encapsulation in self-assembly systems is limited during blood circulation because of a requisite concentration for assembly formation. For deliberate molecular design for stable encapsulation, targeting, and triggered release, we have developed a facile synthetic method for highly stable, polymeric nanogels using a simple intra/interchain cross-linking reaction. We show a simple, emulsion-free method for the preparation of biocompatible nanogels that provides the ability to encapsulate hydrophobic guest molecules and surface functionalization which has potential for targeted delivery. We show that the noncovalently encapsulated guest molecules can be released in response to a biologically relevant stimulus.
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Cited by
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Self-Cross-Linked Polymer Nanogels: A Versatile Nanoscopic Drug Delivery Platform
Ryu, J.-H., Chacko, R. T., Jiwpanich, S., Bickerton, S., Babu, R. P., & Thayumanavan, S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1069932 · Cited by 553
Self-citationBiodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Micro- and nanogels with labile crosslinks – from synthesis to biomedical applications
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Noncovalent Encapsulation Stabilities in Supramolecular Nanoassemblies
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Redox-Responsive Disulfide Cross-Linked PLA-PEG Nanoparticles
Fuoco, T., Pappalardo, D., & Finne-Wistrand, A. (2017) · Macromolecules · doi:10.1021/acs.macromol.7b01318 · Cited by 56
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Metadata
- Authors
- Ryu, J.-H., Jiwpanich, S., Chacko, R., Bickerton, S., & Thayumanavan, S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-05-26
- Volume
- 132
- Issue
- 24
- Pages
- 8246-8247
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2140588070
- Cited by
- 211
- References
- 0
- FWCI
- 7.91
- Type
- journal article
- Language
- en
- Open access
- green
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