The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cell Surface Engineering with Polyelectrolyte Multilayer Thin Films
Abstract
Layer-by-layer assembly of polyelectrolyte multilayer (PEM) films represents a bottom-up approach for re-engineering the molecular landscape of cell surfaces with spatially continuous and molecularly uniform ultrathin films. However, fabricating PEMs on viable cells has proven challenging owing to the high cytotoxicity of polycations. Here, we report the rational engineering of a new class of PEMs with modular biological functionality and tunable physicochemical properties which have been engineered to abrogate cytotoxicity. Specifically, we have discovered a subset of cationic copolymers that undergoes a conformational change, which mitigates membrane disruption and facilitates the deposition of PEMs on cell surfaces that are tailorable in composition, reactivity, thickness, and mechanical properties. Furthermore, we demonstrate the first successful in vivo application of PEM-engineered cells, which maintained viability and function upon transplantation and were used as carriers for in vivo delivery of PEMs containing biomolecular payloads. This new class of polymeric film and the design strategies developed herein establish an enabling technology for cell transplantation and other therapies based on engineered cells.
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Cites
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
International trial of the Edmonton protocol for islet transplantation
Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942
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Factors Influencing the Loss of β-Cell Mass in Islet Transplantation
Emamaullee, J. A., & Shapiro, A. M. J. (2007) · Cell Transplantation · doi:10.3727/000000007783464461 · Cited by 172
Cited by
Technology-driven layer-by-layer assembly of nanofilms
Richardson, J. J., Björnmalm, M., & Caruso, F. (2015) · Science · doi:10.1126/science.aaa2491 · Cited by 1,641
Forming nanomaterials as layered functional structures toward materials nanoarchitectonics
Ariga, K., Ji, Q., Hill, J. P., Bando, Y., & Aono, M. (2012) · NPG Asia Materials · doi:10.1038/am.2012.30 · Cited by 403
Mao, A. S., Shin, J.-W., Utech, S., Wang, H., Uzun, O., Li, W., Cooper, M., Hu, Y., Zhang, L., Weitz, D. A., et al. (2017) · Nature Materials · doi:10.1038/nmat4781 · Cited by 371
Gribova, V., Auzely-Velty, R., & Picart, C. (2012) · Chemistry of Materials · doi:10.1021/cm2032459 · Cited by 338
Polyelectrolyte multilayered assemblies in biomedical technologies
Costa, R. R., & Mano, J. F. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60393h · Cited by 296
Metadata
- Authors
- Wilson, J. T., Cui, W., Kozlovskaya, V., Kharlampieva, E., Pan, D., Qu, Z., Krishnamurthy, V. R., Mets, J., Kumar, V., Wen, J., Song, Y., Tsukruk, V. V., & Chaikof, E. L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-04-14
- Volume
- 133
- Issue
- 18
- Pages
- 7054-7064
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2314486578
- Cited by
- 201
- References
- 5
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- closed
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