The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The Molecular Structure of the Liquid-Ordered Phase of Lipid Bilayers
Open accessAbstract
Molecular dynamics simulations reveal substructures within the liquid-ordered phase of lipid bilayers. These substructures, identified in a 10 μs all-atom trajectory of liquid-ordered/liquid-disordered coexistence (L(o)/L(d)) are composed of saturated hydrocarbon chains packed with local hexagonal order and separated by interstitial regions enriched in cholesterol and unsaturated chains. Lipid hydrocarbon chain order parameters calculated from the L(o) phase are in excellent agreement with (2)H NMR measurements; the local hexagonal packing is also consistent with (1)H-MAS NMR spectra of the L(o) phase, NMR diffusion experiments, and small-angle X-ray and neutron scattering. The balance of cholesterol-rich to local hexagonal order is proposed to control the partitioning of membrane components into the L(o) regions. The latter have been frequently associated with formation of so-called rafts, platforms in the plasma membranes of cells that facilitate interaction between components of signaling pathways.
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Cites
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Constant pressure molecular dynamics algorithms
Martyna, G. J., Tobias, D. J., & Klein, M. L. (1994) · The Journal of Chemical Physics · doi:10.1063/1.467468 · Cited by 5,804
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
Baum, L. E., Petrie, T., Soules, G., & Weiss, N. (1970) · The Annals of Mathematical Statistics · doi:10.1214/aoms/1177697196 · Cited by 4,297
Atomic-level characterization of the structural dynamics of proteins
Shaw, D. E., Maragakis, P., Lindorff-Larsen, K., Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y., et al. (2010) · Science · doi:10.1126/science.1187409 · Cited by 1,923
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
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Phase equilibria in the phosphatidylcholine-cholesterol system
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Cited by
The mystery of membrane organization: composition, regulation and roles of lipid rafts
Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.16 · Cited by 2,124
Molecular Dynamics Simulations of Membrane Permeability
Venable, R. M., Krämer, A., & Pastor, R. W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00486 · Cited by 394
Self-citationPermeability of membranes in the liquid ordered and liquid disordered phases
Ghysels, A., Krämer, A., Venable, R. M., Teague, W. E., Lyman, E., Gawrisch, K., & Pastor, R. W. (2019) · Nature Communications · doi:10.1038/s41467-019-13432-7 · Cited by 136
Self-citationMolecular mechanisms of spontaneous curvature and softening in complex lipid bilayer mixtures
Lessen, H. J., Sapp, K. C., Beaven, A. H., Ashkar, R., & Sodt, A. J. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.07.036 · Cited by 47
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Metadata
- Authors
- Sodt, A. J., Sandar, M. L., Gawrisch, K., Pastor, R. W., & Lyman, E.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-01-03
- Volume
- 136
- Issue
- 2
- Pages
- 725-732
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2313545945
- Cited by
- 256
- References
- 46
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
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