The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The Molecular Structure of the Liquid-Ordered Phase of Lipid Bilayers
Open accessAbstract
Molecular dynamics simulations reveal substructures within the liquid-ordered phase of lipid bilayers. These substructures, identified in a 10 μs all-atom trajectory of liquid-ordered/liquid-disordered coexistence (L(o)/L(d)) are composed of saturated hydrocarbon chains packed with local hexagonal order and separated by interstitial regions enriched in cholesterol and unsaturated chains. Lipid hydrocarbon chain order parameters calculated from the L(o) phase are in excellent agreement with (2)H NMR measurements; the local hexagonal packing is also consistent with (1)H-MAS NMR spectra of the L(o) phase, NMR diffusion experiments, and small-angle X-ray and neutron scattering. The balance of cholesterol-rich to local hexagonal order is proposed to control the partitioning of membrane components into the L(o) regions. The latter have been frequently associated with formation of so-called rafts, platforms in the plasma membranes of cells that facilitate interaction between components of signaling pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
CHARMM‐GUI: A web‐based graphical user interface for CHARMM
Jo, S., Kim, T., Iyer, V. G., & Im, W. (2008) · Journal of Computational Chemistry · doi:10.1002/jcc.20945 · Cited by 9,284
Error bounds for convolutional codes and an asymptotically optimum decoding algorithm
Viterbi, A. (1967) · IEEE Transactions on Information Theory · doi:10.1109/tit.1967.1054010 · Cited by 6,759
Constant pressure molecular dynamics algorithms
Martyna, G. J., Tobias, D. J., & Klein, M. L. (1994) · The Journal of Chemical Physics · doi:10.1063/1.467468 · Cited by 5,804
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
Baum, L. E., Petrie, T., Soules, G., & Weiss, N. (1970) · The Annals of Mathematical Statistics · doi:10.1214/aoms/1177697196 · Cited by 4,297
Atomic-level characterization of the structural dynamics of proteins
Shaw, D. E., Maragakis, P., Lindorff-Larsen, K., Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y., et al. (2010) · Science · doi:10.1126/science.1187409 · Cited by 1,923
Direct observation of the nanoscale dynamics of membrane lipids in a living cell
Eggeling, C., Ringemann, C., Medda, R., Schwarzmann, G., Sandhoff, K., Polyakova, S., Belov, V. N., Hein, B., von Middendorff, C., Schönle, A., et al. (2009) · Nature · doi:10.1038/nature07596 · Cited by 1,520
Rafts defined: a report on the Keystone symposium on lipid rafts and cell function
Pike, L. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.e600002-jlr200 · Cited by 1,500
Phase equilibria in the phosphatidylcholine-cholesterol system
Hjort Ipsen, J., Karlström, G., Mourtisen, O. G., Wennerström, H., & Zuckermann, M. J. (1987) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(87)90020-4 · Cited by 1,059
Seeing spots: Complex phase behavior in simple membranes
Veatch, S. L., & Keller, S. L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.06.010 · Cited by 765
Ordering effects of cholesterol and its analogues
Róg, T., Pasenkiewicz-Gierula, M., Vattulainen, I., & Karttunen, M. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.08.022 · Cited by 609
Critical Fluctuations in Plasma Membrane Vesicles
Veatch, S. L., Cicuta, P., Sengupta, P., Honerkamp-Smith, A., Holowka, D., & Baird, B. (2008) · ACS Chemical Biology · doi:10.1021/cb800012x · Cited by 468
Critical fluctuations in domain-forming lipid mixtures
Veatch, S. L., Soubias, O., Keller, S. L., & Gawrisch, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703513104 · Cited by 442
Self-citationGaussian split Ewald: A fast Ewald mesh method for molecular simulation
Shan, Y., Klepeis, J. L., Eastwood, M. P., Dror, R. O., & Shaw, D. E. (2005) · The Journal of Chemical Physics · doi:10.1063/1.1839571 · Cited by 432
Cell surface organization by the membrane skeleton
Kusumi, A., & Sako, Y. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80036-6 · Cited by 380
Active Remodeling of Cortical Actin Regulates Spatiotemporal Organization of Cell Surface Molecules
Gowrishankar, K., Ghosh, S., Saha, S., C., R., Mayor, S., & Rao, M. (2012) · Cell · doi:10.1016/j.cell.2012.05.008 · Cited by 371
Sezgin, E., Levental, I., Grzybek, M., Schwarzmann, G., Mueller, V., Honigmann, A., Belov, V. N., Eggeling, C., Coskun, Ü., Simons, K., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.03.007 · Cited by 334
Line Tensions, Correlation Lengths, and Critical Exponents in Lipid Membranes Near Critical Points
Honerkamp-Smith, A. R., Cicuta, P., Collins, M. D., Veatch, S. L., den Nijs, M., Schick, M., & Keller, S. L. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.128421 · Cited by 324
Hammond, A. T., Heberle, F. A., Baumgart, T., Holowka, D., Baird, B., & Feigenson, G. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405654102 · Cited by 321
Cholesterol-induced fluid-phase immiscibility in membranes.
Sankaram, M. B., & Thompson, T. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8686 · Cited by 311
Assessing the Nature of Lipid Raft Membranes
Niemelä, P. S., Ollila, S., Hyvönen, M. T., Karttunen, M., & Vattulainen, I. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030034 · Cited by 295
Millisecond-scale molecular dynamics simulations on Anton
Shaw, D. E., Dror, R. O., Salmon, J. K., Grossman, J. P., Mackenzie, K. M., Bank, J. A., Young, C., Deneroff, M. M., Batson, B., Bowers, K. J., et al. (2009) · Proceedings of the Conference on High Performance Computing Networking, Storage and Analysis · doi:10.1145/1654059.1654126 · Cited by 294
Bilayer Thickness Mismatch Controls Domain Size in Model Membranes
Heberle, F. A., Petruzielo, R. S., Pan, J., Drazba, P., Kučerka, N., Standaert, R. F., Feigenson, G. W., & Katsaras, J. (2013) · Journal of the American Chemical Society · doi:10.1021/ja3113615 · Cited by 285
Sankaram, M. B., & Thompson, T. E. (1990) · Biochemistry · doi:10.1021/bi00499a015 · Cited by 238
Progressive ordering with decreasing temperature of the phospholipids of influenza virus
Polozov, I. V., Bezrukov, L., Gawrisch, K., & Zimmerberg, J. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.77 · Cited by 233
Self-citationHinz, H.-J., & Sturtevant, J. M. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45197-1 · Cited by 227
Phase studies of model biomembranes: Complex behavior of DSPC/DOPC/Cholesterol
Zhao, J., Wu, J., Heberle, F. A., Mills, T. T., Klawitter, P., Huang, G., Costanza, G., & Feigenson, G. W. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.008 · Cited by 227
Cholesterol Effects on the Phosphatidylcholine Bilayer Nonpolar Region: A Molecular Simulation Study
Róg, T., & Pasenkiewicz-Gierula, M. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75867-5 · Cited by 217
Comparison of Three Ternary Lipid Bilayer Mixtures: FRET and ESR Reveal Nanodomains
Heberle, F. A., Wu, J., Goh, S. L., Petruzielo, R. S., & Feigenson, G. W. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2010.09.064 · Cited by 209
Presti, F. T., Pace, R. J., & Chan, S. I. (1982) · Biochemistry · doi:10.1021/bi00259a017 · Cited by 182
Sphingomyelin-Cholesterol Domains in Phospholipid Membranes: Atomistic Simulation
Pandit, S. A., Vasudevan, S., Chiu, S. W., Jay Mashl, R., Jakobsson, E., & Scott, H. L. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.041939 · Cited by 171
Phase Boundaries and Biological Membranes
Feigenson, G. W. (2007) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.36.040306.132721 · Cited by 165
Condensed complexes in vesicles containing cholesterol and phospholipids
Radhakrishnan, A., & McConnell, H. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506043102 · Cited by 151
Kusumi, A., Fujiwara, T. K., Morone, N., Yoshida, K. J., Chadda, R., Xie, M., Kasai, R. S., & Suzuki, K. G. N. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.01.018 · Cited by 139
Equilibrium Studies of Lecithin-Cholesterol Interactions
Gershfeld, N. L. (1978) · Biophysical Journal · doi:10.1016/s0006-3495(78)85500-3 · Cited by 138
Cholesterol Induces Specific Spatial and Orientational Order in Cholesterol/Phospholipid Membranes
Martinez‐Seara, H., Róg, T., Karttunen, M., Vattulainen, I., & Reigada, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011162 · Cited by 128
Modulation of the orientational order profile of the lipid acyl chain in the L? phase
Lafleur, M., Cullis, P. R., & Bloom, M. J. (1990) · European Biophysics Journal · doi:10.1007/bf00185086 · Cited by 126
The Observation of Highly Ordered Domains in Membranes with Cholesterol
Armstrong, C. L., Marquardt, D., Dies, H., Kučerka, N., Yamani, Z., Harroun, T. A., Katsaras, J., Shi, A., & Rheinstadter, M. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066162 · Cited by 125
Raftlike Mixtures of Sphingomyelin and Cholesterol Investigated by Solid-State 2H NMR Spectroscopy
Bartels, T., Lankalapalli, R. S., Bittman, R., Beyer, K., & Brown, M. F. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801789t · Cited by 120
Orädd, G., Westerman, P. W., & Lindblom, G. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.061762 · Cited by 97
Cholesterol Orientation and Tilt Modulus in DMPC Bilayers
Khelashvili, G., Pabst, G., & Harries, D. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp101889k · Cited by 90
Endreß, E., Heller, H., Casalta, H., Brown, M. F., & Bayerl, T. M. (2002) · Biochemistry · doi:10.1021/bi0201670 · Cited by 89
Waheed, Q., Tjörnhammar, R. O., & Edholm, O. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.10.014 · Cited by 70
Fan, J., Sammalkorpi, M., & Haataja, M. (2008) · Physical Review Letters · doi:10.1103/physrevlett.100.178102 · Cited by 40
Perlmutter, J. D., & Sachs, J. N. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9079258 · Cited by 24
Cited by
The mystery of membrane organization: composition, regulation and roles of lipid rafts
Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.16 · Cited by 2,124
Molecular Dynamics Simulations of Membrane Permeability
Venable, R. M., Krämer, A., & Pastor, R. W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00486 · Cited by 394
Self-citationPermeability of membranes in the liquid ordered and liquid disordered phases
Ghysels, A., Krämer, A., Venable, R. M., Teague, W. E., Lyman, E., Gawrisch, K., & Pastor, R. W. (2019) · Nature Communications · doi:10.1038/s41467-019-13432-7 · Cited by 136
Self-citationMolecular mechanisms of spontaneous curvature and softening in complex lipid bilayer mixtures
Lessen, H. J., Sapp, K. C., Beaven, A. H., Ashkar, R., & Sodt, A. J. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.07.036 · Cited by 47
Self-citation
Metadata
- Authors
- Sodt, A. J., Sandar, M. L., Gawrisch, K., Pastor, R. W., & Lyman, E.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-01-03
- Volume
- 136
- Issue
- 2
- Pages
- 725-732
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2313545945
- Cited by
- 256
- References
- 46
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
