Cited by 273

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Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues

Peng, Tao, Wong, Nai-Kei, Chen, Xingmiao, Chan, Yee-Kwan, Ho, Derek Hoi-Hang, Sun, Zhenning, Hu, Jun Jacob, Shen, Jiangang, El-Nezami, Hani, Yang, Dan·2014·Journal of the American Chemical Society

DOI 10.1021/ja504624q

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Abstract

Peroxynitrite (ONOO(-)), the product of a radical combination reaction of nitric oxide and superoxide, is a potent biological oxidant involved in a broad spectrum of physiological and pathological processes. Herein we report the development, characterization, and biological applications of a new fluorescent probe, HKGreen-4, for peroxynitrite detection and imaging. HKGreen-4 utilizes a peroxynitrite-triggered oxidative N-dearylation reaction to achieve an exceptionally sensitive and selective fluorescence turn-on response toward peroxynitrite in chemical systems and biological samples. We have thoroughly evaluated the utility of HKGreen-4 for intracellular peroxynitrite imaging and, more importantly, demonstrated that HKGreen-4 can be efficiently employed to visualize endogenous peroxynitrite generated in Escherichia coli-challenged macrophages and in live tissues from a mouse model of atherosclerosis. This probe should serve as a powerful molecular imaging tool to explore peroxynitrite biology under a variety of physiological and pathological contexts.

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Authors: Peng, T., Wong, N.-K., Chen, X., Chan, Y.-K., Ho, D. H.-H., Sun, Z., Hu, J. J., Shen, J., El-Nezami, H., & Yang, D.
Venue: Journal of the American Chemical Society
Publisher: American Chemical Society (ACS)
Published: 2014-08-07
Volume: 136
Issue: 33
Pages: 11728-11734
ISSN: 0002-7863 (ISSN-L)
1520-5126
DOI: 10.1021/ja504624q
OpenAlex: W2053951897
Cited by: 273
References: 72
FWCI: 9.80
Type: journal article
Language: en
Open access: closed

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Molecular Imaging of Peroxynitrite with HKGreen-4 in Live Cells and Tissues

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