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Cited by 339

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Multistimuli-Responsive Supramolecular Vesicles Based on Water-Soluble Pillar[6]arene and SAINT Complexation for Controllable Drug Release

Cao, Yu, Hu, Xiao-Yu, Li, Yan, Zou, Xiaochun, Xiong, Shuhan, Lin, Chen, Shen, Ying-Zhong, Wang, Leyong·2014·Journal of the American Chemical Society
DOI 10.1021/ja505344t
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Abstract

Supramolecular binary vesicles based on the host-guest complexation of water-soluble pillar[6]arene (WP6) and SAINT molecule have been successfully constructed, which showed pH-, Ca(2+)-, and thermal-responsiveness. These supramolecular vesicles can efficiently encapsulate model substrate calcein, which then can be efficiently released either by adjusting the solution pH to acidic condition due to the complete disruption of vesicular structure, or particularly, by adding a certain amount of Ca(2+) due to the Ca(2+)-induced vesicle fusion and accompanied by the structure disruption. More importantly, drug loading and releasing experiments demonstrate that an anticancer drug, DOX, can be successfully encapsulated by the supramolecular vesicles, and the resulting DOX-loaded vesicles exhibit efficient release of the encapsulated DOX with the pH adjustment or the introduction of Ca(2+). Cytotoxicity experiments suggest that the resulting DOX-loaded supramolecular vesicles exhibit comparable therapeutic effect for cancer cells as free DOX and the remarkably reduced damage for normal cells as well. The present multistimuli-responsive supramolecular vesicles have great potential applications in the field of controlled drug delivery. In addition, giant supramolecular vesicles (~3 μm) with large internal volume and good stability can be achieved by increasing the temperature of WP6 ⊃ SAINT vesicular solution, and they might have potential applications for bioimaging.

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Metadata

Authors
Cao, Y., Hu, X.-Y., Li, Y., Zou, X., Xiong, S., Lin, C., Shen, Y.-Z., & Wang, L.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2014-07-17
Volume
136
Issue
30
Pages
10762-10769
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/ja505344t
OpenAlex
W2333280212
Cited by
339
References
42
FWCI
23.13
Type
journal article
Language
en
Open access
closed

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