Cited by 65Supramolecular Chemistry and ComplexesNanoparticle-Based Drug DeliverySupramolecular Self-Assembly in Materials

Enzyme-responsive protein/polysaccharide supramolecular nanoparticles

Hou, Xiao-Fang, Chen, Yong, Liu, Yu·2015·Soft Matter

Abstract

Biocompatible and enzyme-responsive supramolecular assemblies have attracted more and more interest in biomaterial fields, and find many feasible applications especially in the controlled drug release at specific sites where the target enzyme is located. In this work, novel supramolecular nanoparticles were successfully constructed from two biocompatible materials, i.e. a cyclic polysaccharide named sulfato-β-cyclodextrin (SCD) and a protein named protamine, through non-covalent association, and fully characterized by means of atomic force microscopy (AFM) and high-resolution transmission electron microscopy (TEM). Significantly, the disassembly of the resulting nanoparticles can respond especially to trypsin over other enzymes. Owing to their trypsin-triggered disassembly behaviors, these nanoparticles can efficiently release the encapsulated model substrate in a controlled manner. That is, the model substrate can be encapsulated inside the nanoparticles with a high stability and released when treated with trypsin.

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Crossref · 10.1039/c4sm02896a

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42 of 42 references verified0 citation errors · 0 not checkable

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  • Hyaluronidase, γ-Glutamyltranspeptidase, prostate-specific antigen, Trysin, β-galactosidase, Azoreductase, etc. are also used in enzyme-stimulated response smart nano-delivery systems.

    “In addition, hyaluronidase, γ-Glutamyltranspeptidase, prostate-specific antigen, Trysin, β-galactosidase, Azoreductase, etc. are also used in enzyme-stimulated response smart nano-delivery systems.157–162”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [160]

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Authors
Hou, X.-F., Chen, Y., & Liu, Y.
Affiliations
Nankai University (CN)
Corresponding author
Liu, Yu
Venue
Soft Matter
Published
2015
Volume
11
Issue
12
Pages
2488-2493
ISSN
  • 1744-683X (ISSN-L)
  • 1744-6848
OpenAlex
W2153105709
Cited by
65
References
42
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 3
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Locations
  • Soft Matter (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Key Research and Development Program of China
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
Keywords
enzyme-responsive nanoparticles, supramolecular nanoparticles, protamine, controlled drug release, non-covalent association, protein-polysaccharide complexes, nanoparticle encapsulation
MeSH terms
Biocompatible Materials, Enzymes, Polymers, Protamines, beta-Cyclodextrins, Nanoparticles, Biocatalysis

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