Enzyme-responsive protein/polysaccharide supramolecular nanoparticles
Abstract
Biocompatible and enzyme-responsive supramolecular assemblies have attracted more and more interest in biomaterial fields, and find many feasible applications especially in the controlled drug release at specific sites where the target enzyme is located. In this work, novel supramolecular nanoparticles were successfully constructed from two biocompatible materials, i.e. a cyclic polysaccharide named sulfato-β-cyclodextrin (SCD) and a protein named protamine, through non-covalent association, and fully characterized by means of atomic force microscopy (AFM) and high-resolution transmission electron microscopy (TEM). Significantly, the disassembly of the resulting nanoparticles can respond especially to trypsin over other enzymes. Owing to their trypsin-triggered disassembly behaviors, these nanoparticles can efficiently release the encapsulated model substrate in a controlled manner. That is, the model substrate can be encapsulated inside the nanoparticles with a high stability and released when treated with trypsin.
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Hyaluronidase, γ-Glutamyltranspeptidase, prostate-specific antigen, Trysin, β-galactosidase, Azoreductase, etc. are also used in enzyme-stimulated response smart nano-delivery systems.
“In addition, hyaluronidase, γ-Glutamyltranspeptidase, prostate-specific antigen, Trysin, β-galactosidase, Azoreductase, etc. are also used in enzyme-stimulated response smart nano-delivery systems.157–162”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [160]
Cites
Complexation Thermodynamics of Cyclodextrins
Rekharsky, M. V., & Inoue, Y. (1998) · Chemical Reviews · doi:10.1021/cr970015o · Cited by 3,201 · see citing works
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023 · see citing works
Cyclodextrin Drug Carrier Systems
Uekama, K., Hirayama, F., & Irie, T. (1998) · Chemical Reviews · doi:10.1021/cr970025p · Cited by 2,148 · see citing works
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic‐Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,734 · see citing works
Vriezema, D. M., Comellas-Aragonès, M., Elemans, J. A. A. W., Cornelissen, J. J. L. M., Rowan, A. E., & Nolte, R. J. M. (2005) · Chemical Reviews · doi:10.1021/cr0300688 · Cited by 1,462 · see citing works
Cucurbiturils: from synthesis to high-affinity binding and catalysis
Assaf, K. I., & Nau, W. M. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00273c · Cited by 1,370 · see citing works
Functionalized cucurbiturils and their applications
Kim, K., Selvapalam, N., Ko, Y. H., Park, K. M., Kim, D., & Kim, J. (2006) · Chemical Society Reviews · doi:10.1039/b603088m · Cited by 919 · see citing works
Cyclodextrin-based supramolecular polymers
Harada, A., Takashima, Y., & Yamaguchi, H. (2009) · Chemical Society Reviews · doi:10.1039/b705458k · Cited by 861 · see citing works
Amphiphilic Building Blocks for Self-Assembly: From Amphiphiles to Supra-amphiphiles
Wang, C., Wang, Z., & Zhang, X. (2012) · Accounts of Chemical Research · doi:10.1021/ar200226d · Cited by 740 · see citing works
Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels
Hu, J., Zhang, G., & Liu, S. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35103j · Cited by 723 · see citing works
Zhang, X., & Wang, C. (2010) · Chemical Society Reviews · doi:10.1039/b919678c · Cited by 705 · see citing works
Duan, Q., Cao, Y., Li, Y., Hu, X., Xiao, T., Chen, L., Pan, Y., & Wang, L. (2013) · Journal of the American Chemical Society · doi:10.1021/ja405014r · Cited by 644 · see citing works
Calixarene-based supramolecular polymerization in solution
Guo, D., & Liu, Y. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35075k · Cited by 621 · see citing works
Self-citationpH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock Copolymer
Du, J., Tang, Y., Lewis, A. L., & Armes, S. P. (2005) · Journal of the American Chemical Society · doi:10.1021/ja056514l · Cited by 603 · see citing works
Vesicular perylene dye nanocapsules as supramolecular fluorescent pH sensor systems
Zhang, X., Rehm, S., Safont‐Sempere, M. M., & Würthner, F. (2009) · Nature Chemistry · doi:10.1038/nchem.368 · Cited by 597 · see citing works
Kumpfer, J. R., & Rowan, S. J. (2011) · Journal of the American Chemical Society · doi:10.1021/ja205332w · Cited by 487 · see citing works
Yu, G., Zhou, X., Zhang, Z., Han, C., Mao, Z., Gao, C., & Huang, F. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3099905 · Cited by 486 · see citing works
Wang, Y., Xu, H., & Zhang, X. (2009) · Advanced Materials · doi:10.1002/adma.200803276 · Cited by 462 · see citing works
Ultrahigh-Water-Content Supramolecular Hydrogels Exhibiting Multistimuli Responsiveness
Appel, E. A., Loh, X. J., Jones, S. T., Biedermann, F., Dreiss, C. A., & Scherman, O. A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3044568 · Cited by 443 · see citing works
Cyclodextrin-based bioactive supramolecular assemblies
Chen, Y., & Liu, Y. (2009) · Chemical Society Reviews · doi:10.1039/b816354p · Cited by 433 · see citing works
Self-citationSwitchable Host–Guest Systems on Surfaces
Yang, Y., Sun, Y., & Song, N. (2014) · Accounts of Chemical Research · doi:10.1021/ar500022f · Cited by 421 · see citing works
Cholinesterase-Responsive Supramolecular Vesicle
Guo, D., Wang, K., Wang, Y., & Liu, Y. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303280r · Cited by 413 · see citing works
Self-citationToward a Single-Layer Two-Dimensional Honeycomb Supramolecular Organic Framework in Water
Zhang, K., Tian, J., Hanifi, D. A., Zhang, Y., Sue, A. C. ‐., Zhou, T., Zhang, L., Zhao, X., Liu, Y., & Li, Z. (2013) · Journal of the American Chemical Society · doi:10.1021/ja4086935 · Cited by 403 · see citing works
Self-citationCao, Y., Hu, X., Li, Y., Zou, X., Xiong, S., Chen, L., Shen, Y., & Wang, L. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505344t · Cited by 339 · see citing works
Tan, L., Li, H., Tao, Y., Zhang, S. X., Wang, B., & Yang, Y. (2014) · Advanced Materials · doi:10.1002/adma.201401672 · Cited by 286 · see citing works
A synthetic mimic of the secretory granule for drug delivery
Kiser, P. F., Wilson, G., & Needham, D. (1998) · Nature · doi:10.1038/28822 · Cited by 263 · see citing works
Three-dimensional periodic supramolecular organic framework ion sponge in water and microcrystals
Tian, J., Zhou, T., Zhang, S., Aloni, S., Altoé, M. V. P., Xie, S., Wang, H., Zhang, D., Zhao, X., Liu, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms6574 · Cited by 230 · see citing works
Self-citationSupramolecular Polymerization Promoted and Controlled through Self‐Sorting
Huang, Z., Yang, L., Liu, Y., Wang, Z., Scherman, O. A., & Zhang, X. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201402817 · Cited by 215 · see citing works
Self-citationChemistry inside molecular containers in the gas phase
Lee, T., Kalenius, E., Lazar, A. I., Assaf, K. I., Kuhnert, N., Grün, C. H., Jänis, J., Scherman, O. A., & Nau, W. M. (2013) · Nature Chemistry · doi:10.1038/nchem.1618 · Cited by 159 · see citing works
Host‐Enhanced π–π Interaction for Water‐Soluble Supramolecular Polymerization
Liu, Y., Liu, K., Wang, Z., & Zhang, X. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201101611 · Cited by 122 · see citing works
Self-citationAlmutairi, A., Guillaudeu, S. J., Berezin, M. Y., Achilefu, S. A., & Fréchet, J. M. J. (2007) · Journal of the American Chemical Society · doi:10.1021/ja078147e · Cited by 120 · see citing works
Protamine as an Efficient Membrane-Translocating Peptide
Reynolds, F., Weissleder, R., & Josephson, L. (2005) · Bioconjugate Chemistry · doi:10.1021/bc0501451 · Cited by 100 · see citing works
Randolph, L. M., Chien, M., & Gianneschi, N. C. (2012) · Chemical Science · doi:10.1039/c2sc00857b · Cited by 89 · see citing works
Wang, K., Guo, D., Zhao, M., & Liu, Y. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201303963 · Cited by 87 · see citing works
Self-citationMultidimensional nanoarchitectures based on cyclodextrins
Chen, Y., Zhang, Y., & Liu, Y. (2010) · Chemical Communications · doi:10.1039/c0cc00690d · Cited by 86 · see citing works
Self-citationJiao, D., Biedermann, F., Tian, F., & Scherman, O. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja106716j · Cited by 74 · see citing works
Self-Assembly of Nonionic Surfactant Tween 20@2β-CD Inclusion Complexes in Dilute Solution
Zhou, C., Cheng, X., Zhao, Q., Yan, Y., Wang, J., & Huang, J. (2013) · Langmuir · doi:10.1021/la403257v · Cited by 73 · see citing works
Qin, Z., Guo, D., Gao, X.-N., & Liu, Y. (2013) · Soft Matter · doi:10.1039/c3sm52866a · Cited by 71 · see citing works
Self-citationReversible Transition between SDS@2β-CD Microtubes and Vesicles Triggered by Temperature
Zhou, C., Cheng, X., Yan, Y., Wang, J., & Huang, J. (2014) · Langmuir · doi:10.1021/la500010p · Cited by 60 · see citing works
Peng, S., Wang, K., Guo, D., & Liu, Y. (2014) · Soft Matter · doi:10.1039/c4sm02170c · Cited by 38 · see citing works
Self-citationAmphiphilic diselenide-containing supramolecular polymers
Tan, X., Yang, L., Huang, Z., Yu, Y. H., Wang, Z., & Zhang, X. (2014) · Polymer Chemistry · doi:10.1039/c4py01440e · Cited by 37 · see citing works
van Hest, J. C. M. (2009) · Nature · doi:10.1038/461045a · Cited by 12 · see citing works
Flagged first, then by citations
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Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,526 · see citing works
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics
Mi, P. (2020) · Theranostics · doi:10.7150/thno.38069 · Cited by 843 · see citing works
Nanoparticle-Mediated Delivery towards Advancing Plant Genetic Engineering
Cunningham, F. J., Goh, N. S., Demirer, G. S., Matos, J. L., & Landry, M. P. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.03.009 · Cited by 501 · see citing works
Cyclodextrin‐Based Multistimuli‐Responsive Supramolecular Assemblies and Their Biological Functions
Zhang, Y., Liu, Y., & Liu, Y. (2019) · Advanced Materials · doi:10.1002/adma.201806158 · Cited by 402 · see citing works
Self-citationA Supramolecular Artificial Light‐Harvesting System with an Ultrahigh Antenna Effect
Li, J., Chen, Y., Yu, J., Cheng, N., & Liu, Y. (2017) · Advanced Materials · doi:10.1002/adma.201701905 · Cited by 265 · see citing works
Self-citationLiu, J., Cabral, H., & Mi, P. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115239 · Cited by 239 · see citing works
Lu, K.-Y., Li, R., Hsu, C., Lin, C., Chou, S.-C., Tsai, M., & Mi, F. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.02.065 · Cited by 176 · see citing works
Stimulus-Responsive Hydrogels for Targeted Cancer Therapy
Solanki, R., & Bhatia, D. D. (2024) · Gels · doi:10.3390/gels10070440 · Cited by 117 · see citing works
Zhang, Z.-T., Huang-Fu, M.-Y., Xu, W.-H., & Han, M. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.02.009 · Cited by 82 · see citing works
Guan, X., Chen, Y., Wu, X., Li, P., & Liu, Y. (2018) · Chemical Communications · doi:10.1039/c8cc09047e · Cited by 73 · see citing works
Self-citationBoushehri, M. A. S., Dietrich, D., & Lamprecht, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12060510 · Cited by 71 · see citing works
Sulfonato-β-Cyclodextrin Mediated Supramolecular Nanoparticle for Controlled Release of Berberine
Chen, X., Chen, Y., Hou, X., Wu, X., Gu, B., & Liu, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b08651 · Cited by 63 · see citing works
Self-citationDon, T., Lu, K.-Y., Lin, L.-J., Hsu, C., Wu, J.-Y., & Mi, F. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00737 · Cited by 60 · see citing works
Cui, X., Liang, Z., Lu, J., Wang, X., Jia, F., Hu, Q., Xiao, X., Deng, X., Wu, Y. F., & Sheng, W. (2021) · Nanoscale · doi:10.1039/d1nr03161a · Cited by 46 · see citing works
Recent advances in assemblies of cyclodextrins and amphiphiles: construction and regulation
Liu, K., Ma, C., Wu, T., Qi, W., Yan, Y., & Huang, J. (2019) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2019.11.007 · Cited by 38 · see citing works
Hou, X., Zhang, S., Chen, X. D., Bisoyi, H. K., Xu, T., Liu, J., Chen, D., Chen, X., & Li, Q. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c02851 · Cited by 38 · see citing works
Self-citationRecent Advances in Gelatin-Based Nanomedicine for Targeted Delivery of Anti-Cancer Drugs
Raza, F., Liu, S., Zafar, H., Kamal, Z., Zheng, B., Su, J., & Qiu, M. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666211102100118 · Cited by 36 · see citing works
Photolysis of a bola-type supra-amphiphile promoted by water-soluble pillar[5]arene-induced assembly
Guo, S., Liu, X., Yao, C., Lu, C., Chen, Q., Hu, X., & Wang, L. (2016) · Chemical Communications · doi:10.1039/c6cc05993g · Cited by 35 · see citing works
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms
Chen, X., Lei, S., Lin, J., & Huang, P. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2134853 · Cited by 33 · see citing works
Agazzi, M. L., Herrera, S. E., Cortez, M. L., Marmisollé, W. A., & Azzaroni, O. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110895 · Cited by 33 · see citing works
Jin, X., Song, N., Wang, X., Wang, C., Wang, Y., & Yang, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-22446-y · Cited by 30 · see citing works
Bioresponsive engineered nanoparticles for immunomodulation
Hegde, M., Mishra, A., Banerjee, R., Bintee, B., Alqahtani, M. S., Abbas, M., Shanmugam, M. K., Drum, C. L., Sethi, G., Liu, L., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04305-6 · Cited by 33 · see citing works
Supramolecular dissipative self‐assembly systems: Approaches and applications
Hou, X., Chen, X., Wei, J., Xu, Y., Chen, X., & Li, Q. (2023) · Responsive materials · doi:10.1002/rpm.20230016 · Cited by 28 · see citing works
Self-citationPolyanionic Cyclodextrin Induced Supramolecular Nanoparticle
Sun, H., Zhang, Y., Chen, Y., & Liu, Y. (2016) · Scientific Reports · doi:10.1038/s41598-016-0026-z · Cited by 25 · see citing works
Self-citationAutonomous Drug Release Systems with Disease Symptom‐Associated Triggers
Xiong, Y., Qi, L., Niu, Y., Lin, Y., Xue, Q., & Zhao, Y. (2020) · Advanced Intelligent Systems · doi:10.1002/aisy.201900124 · Cited by 24 · see citing works
Enzyme-Responsive Materials: Properties, Design, and Applications
Yousefiasl, S., Zare, I., Ghovvati, M., & Ghomi, M. (2023) · ACS symposium series · doi:10.1021/bk-2023-1436.ch009 · Cited by 24 · see citing works
Liang, L., Chen, Y., Chen, X., Zhang, Y., & Liu, Y. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2017.12.022 · Cited by 24 · see citing works
Self-citationXu, H., Chen, Y., Sun, H., & Liu, Y. (2018) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201800076 · Cited by 23 · see citing works
Self-citationChen, S., He, H., Tang, G., Wu, B., Ma, M., Shi, Y., & Wang, X. (2015) · RSC Advances · doi:10.1039/c5ra17991b · Cited by 21 · see citing works
Cuggino, J. C., Ambrosioni, F. E., Picchio, M. L., Nicola, M., Jimenez-Kairuz, A. F., Gatti, G., Minari, R. J., Calderón, M., Igarzabal, C. I. Á., & Gugliotta, L. M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.03.138 · Cited by 19 · see citing works
Maize tissue culture, transformation, and genome editing
Kausch, A. P., Nelson‐Vasilchik, K., Tilelli, M., & Hague, J. P. (2021) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-021-10196-y · Cited by 19 · see citing works
Hu, P., Chen, Y., Li, J., & Liu, Y. (2015) · Chemistry - An Asian Journal · doi:10.1002/asia.201501029 · Cited by 18 · see citing works
Self-citationControlled Actuation of Therapeutic nanoparticles: an Update on Recent Progress
Nag, O. K., Field, L. D., Chen, Y., Sangtani, A., Breger, J. C., & Delehanty, J. B. (2016) · Therapeutic Delivery · doi:10.4155/tde-2016-0003 · Cited by 15 · see citing works
Self-citationDeng, X., Yin, Z., Lu, J., Xia, Y., Shao, L., Hu, Q., Zhou, Z., Zhang, F., Zhou, S., Wu, Y. F., et al. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11438 · Cited by 15 · see citing works
Theranostic Approach for the Protein Corona of Polysaccharide Nanoparticles
Skalíčková, S., Horký, P., Mlejnková, V., Skládanka, J., Hosnedlová, B., Ruttkay-Nedecký, B., Fernández, C., & Kizek, R. (2020) · The Chemical Record · doi:10.1002/tcr.202000042 · Cited by 14 · see citing works
Enzyme-Responsive Supramolecular Self-Assembly in Small Amphiphiles
Xiao, X., & Huang, J. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c01762 · Cited by 14 · see citing works
Shi, R., Chen, Y., Hou, X., & Liu, Y. (2016) · RSC Advances · doi:10.1039/c5ra28043e · Cited by 13 · see citing works
Self-citationSayed, M., Panjwani, S., & Pal, H. (2018) · ChemistrySelect · doi:10.1002/slct.201801563 · Cited by 12 · see citing works
Self‐Assembled Nanovehicle for Intracellular Enzyme‐Triggered Antitumor Drug Release
Zhang, J., Chen, S., Teng, J., Li, B., Wang, L., Yang, J., & Zhao, Y. (2022) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202200028 · Cited by 11 · see citing works
Zhao, X., Chen, Y., Dai, X., Zhou, W., Li, J., & Liu, Y. (2020) · Advanced Photonics Research · doi:10.1002/adpr.202000007 · Cited by 10 · see citing works
Self-citationChen, F., Li, H., Zhen, C., Lin, G., Tang, B., Shi, Y., Wang, L., Qiao, J., & Li, X. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37938 · Cited by 10 · see citing works
Multicolor luminescent supramolecular hydrogels based on cucurbit[8]uril and OPV derivative
Yong-Zhen, C., Chen, Y., & Liu, Y. (2019) · Soft Matter · doi:10.1039/c9sm02004g · Cited by 10 · see citing works
Self-citationInternal stimuli-responsive Nanocarriers for Controlled anti-cancer Drug Release: a Review
Shaik, B. B., Katari, N. K., & Jonnalagadda, S. B. (2023) · Therapeutic Delivery · doi:10.4155/tde-2023-0041 · Cited by 9 · see citing works
Shao, L., Hua, B., Yang, J., & Yu, G. (2016) · RSC Advances · doi:10.1039/c6ra12183g · Cited by 9 · see citing works
Stimuli-responsive cyclodextrin-based materials for biomedical applications
Devika, V., Sreelekshmi, P. J., Pai, R. G., Archana, T. S., Kavya, K. S., Nair, P. B., Velagaleti, C. S. L., & Sadanandan, S. (2024) · Materials Today Proceedings · doi:10.1016/j.matpr.2024.05.130 · Cited by 8 · see citing works
Guan, X., Chen, Y., Guo, P. F., Li, P., & Liu, Y. (2020) · Chemical Communications · doi:10.1039/d0cc02518f · Cited by 7 · see citing works
Self-citationJin, W., Yue, L., Chi, S., Yang, T., Ruan, Q., Zhu, H.-Y., Lei, Z., & Zhao, Y. (2021) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2021.2006685 · Cited by 5 · see citing works
Revealing the Molecular Physics of Lattice Self-Assembly by Vibrational Hyperspectral Imaging
Wang, H., & Xiong, W. (2022) · Langmuir · doi:10.1021/acs.langmuir.1c03313 · Cited by 4 · see citing works
Advances in the Development of Supramolecular Polymeric Biomaterials
Goor, O. J. G. M., & Dankers, P. Y. W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12574-0 · Cited by 3 · see citing works
An overview of stimuli-responsive nanocarriers: State of the art
Kumar, P., Salve, R., Gajbhiye, K. R., & Gajbhiye, V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824456-2.00004-7 · Cited by 3 · see citing works
Hou, X., Huan, M., Zhang, Y., Zhang, J., Zhang, L., Zhang, X., Xu, Y., & Mao, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142960 · Cited by 2 · see citing works
Self-citationRetractedHu, P., Chen, Y., & Liu, Y. (2015) · RSC Advances · doi:10.1039/c5ra19122j · Cited by 2 · see citing works
Self-citationMultichannel dual protein sensing using amphiphilic supramolecular assemblies
Gao, J., Prachyathipsakul, T., & Thayumanavan, S. (2021) · Chemical Communications · doi:10.1039/d1cc05407d · Cited by 2 · see citing works
Jin, Z., Wen, Y., & Wei, Z. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.147556 · Cited by 1 · see citing works
Zhang, Y., Sun, P., Deng, Z.-K., Cheng, Q.-W., Zhang, Y., Chen, Y., & Liu, Y. (2026) · Science China Chemistry · doi:10.1007/s11426-025-3216-8 · Cited by 1 · see citing works
Self-citationPhotolysis Behaviors of Anthryl Derivative Aggregation Mediated by Sulfato‐β‐Cyclodextrin
Zhao, X., Chen, Y., Guan, X., Li, P., Zhou, W., & Liu, Y. (2019) · ChemistrySelect · doi:10.1002/slct.201903889 · Cited by 1 · see citing works
Self-citationHashidzume, A., Kamon, Y., & Harada, A. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166136-00298 · Cited by 1 · see citing works
Nanoscaled Cyclodextrin Supermolecular System for Drug and Gene Delivery
Dai, X., Chen, Y., & Liu, Y. (2019) · Springer eBooks · doi:10.1007/978-981-13-1744-6_67-1 · Cited by 1 · see citing works
Self-citationSupramolecular Assembly Constructed from Multi-charged Cyclodextrin-Induced Aggregation
Li, P., Chen, Y., & Liu, Y. (2019) · Springer eBooks · doi:10.1007/978-981-13-1744-6_23-1
Self-citationSupramolecular Assembly Constructed from Multi-charged Cyclodextrin-Induced Aggregation
Li, P., Chen, Y., & Liu, Y. (2020) · Springer eBooks · doi:10.1007/978-981-15-2686-2_23
Self-citationNanoscaled Cyclodextrin Supermolecular System for Drug and Gene Delivery
Dai, X., Chen, Y., & Liu, Y. (2020) · Springer eBooks · doi:10.1007/978-981-15-2686-2_67
Self-citationDaemi, H., Mohammadian‐Sabet, F., Sobhkhiz, Z., Nazemi, Z., Shayesteh, A., Angji, M. T., & Baharvand, H. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4581558
Miskolczy, Z., Megyesi, M., Huszka, B. M., Mándity, I. M., & Biczók, L. (2025) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2025.101053
The Role of Cyclodextrins in Modulating Stimuli-Responsiveness for Anticancer Drug Delivery
Cesari, A., Zhengming, L., & Bellina, F. (2026) · Pharmaceutical Research · doi:10.1007/s11095-026-04096-2
- Authors
- Hou, X.-F., Chen, Y., & Liu, Y.
- Affiliations
- Nankai University (CN)
- Corresponding author
- Liu, Yu
- ORCID
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 11
- Issue
- 12
- Pages
- 2488-2493
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2153105709
- Cited by
- 65
- References
- 42
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 3
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Soft Matter (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Supramolecular Chemistry and Complexes
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- enzyme-responsive nanoparticles, supramolecular nanoparticles, protamine, controlled drug release, non-covalent association, protein-polysaccharide complexes, nanoparticle encapsulation
- MeSH terms
- Biocompatible Materials, Enzymes, Polymers, Protamines, beta-Cyclodextrins, Nanoparticles, Biocatalysis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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