The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nanoscale Metal–Organic Frameworks for Real-Time Intracellular pH Sensing in Live Cells
Open accessAbstract
Real-time measurement of intracellular pH in live cells is of great importance for understanding physiological/pathological processes and developing intracellular drug delivery systems. We report here the first use of nanoscale metal-organic frameworks (NMOFs) for intracellular pH sensing in live cells. Fluorescein isothiocyanate (FITC) was covalently conjugated to a UiO NMOF to afford F-UiO NMOFs with exceptionally high FITC loadings, efficient fluorescence, and excellent ratiometric pH-sensing properties. Upon rapid and efficient endocytosis, F-UiO remained structurally intact inside endosomes. Live cell imaging studies revealed endo- and exocytosis of F-UiO and endosome acidification in real time. Fluorescently labeled NMOFs thus represent a new class of nanosensors for intracellular pH sensing and provide an excellent tool for studying NMOF-cell interactions.
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He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Self-citationHarding, J. L., & Reynolds, M. M. (2014) · J. Mater. Chem. B · doi:10.1039/c3tb21458c · Cited by 43
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Kumar, P., Pournara, A., Kim, K.-H., Bansal, V., Rapti, S., & Manos, M. J. (2017) · Progress in Materials Science · doi:10.1016/j.pmatsci.2017.01.002 · Cited by 423
Nanoscale Metal–Organic Frameworks for Ratiometric Oxygen Sensing in Live Cells
Xu, R., Wang, Y., Duan, X., Lu, K., Micheroni, D., Hu, A., & Lin, W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b13458 · Cited by 319
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Metadata
- Authors
- He, C., Lu, K., & Lin, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-25
- Volume
- 136
- Issue
- 35
- Pages
- 12253-12256
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2330395753
- Cited by
- 294
- References
- 2
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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