The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Nanoscale Metal–Organic Frameworks for Real-Time Intracellular pH Sensing in Live Cells
Open accessAbstract
Real-time measurement of intracellular pH in live cells is of great importance for understanding physiological/pathological processes and developing intracellular drug delivery systems. We report here the first use of nanoscale metal-organic frameworks (NMOFs) for intracellular pH sensing in live cells. Fluorescein isothiocyanate (FITC) was covalently conjugated to a UiO NMOF to afford F-UiO NMOFs with exceptionally high FITC loadings, efficient fluorescence, and excellent ratiometric pH-sensing properties. Upon rapid and efficient endocytosis, F-UiO remained structurally intact inside endosomes. Live cell imaging studies revealed endo- and exocytosis of F-UiO and endosome acidification in real time. Fluorescently labeled NMOFs thus represent a new class of nanosensors for intracellular pH sensing and provide an excellent tool for studying NMOF-cell interactions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Horcajada, P., Chalati, T., Serre, C., Gillet, B., Sebrie, C., Baati, T., Eubank, J. F., Heurtaux, D., Clayette, P., Kreuz, C., et al. (2010) · Nature Materials · doi:10.1038/nmat2608 · Cited by 4,260
Homochiral Metal–Organic Frameworks for Asymmetric Heterogeneous Catalysis
Yoon, M., Srirambalaji, R., & Kim, K. (2012) · Chemical Reviews · doi:10.1021/cr2003147 · Cited by 2,856
Strategies for Hydrogen Storage in Metal–Organic Frameworks
Rowsell, J. L. C., & Yaghi, O. M. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200462786 · Cited by 2,463
Huotari, J., & Helenius, A. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.286 · Cited by 2,265
Dysregulated pH: a perfect storm for cancer progression
Webb, B. A., Chimenti, M., Jacobson, M. P., & Barber, D. L. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3110 · Cited by 2,237
Sensors and regulators of intracellular pH
Casey, J. R., Grinstein, S., & Orlowski, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2820 · Cited by 2,218
Nanoscale Metal–Organic Frameworks for Biomedical Imaging and Drug Delivery
Della Rocca, J., Liu, D., & Lin, W. (2011) · Accounts of Chemical Research · doi:10.1021/ar200028a · Cited by 2,087
Self-citationFluorescent Indicators for Intracellular pH
Han, J., & Burgess, K. (2010) · Chemical Reviews · doi:10.1021/cr900249z · Cited by 1,620
He, C., Lu, K., Liu, D., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4098862 · Cited by 885
Self-citationZhuang, J., Kuo, C.-H., Chou, L.-Y., Liu, D.-Y., Weerapana, E., & Tsung, C.-K. (2014) · ACS Nano · doi:10.1021/nn406590q · Cited by 873
Cited by
Nanomaterials: a review of synthesis methods, properties, recent progress, and challenges
Baig, N., Kammakakam, I., & Falath, W. (2021) · Materials Advances · doi:10.1039/d0ma00807a · Cited by 3,262
Zr-based metal–organic frameworks: design, synthesis, structure, and applications
Bai, Y., Dou, Y., Xie, L.-H., Rutledge, W., Li, J.-R., & Zhou, H.-C. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00837a · Cited by 2,545
Li, J., Wang, X., Zhao, G., Chen, C., Chai, Z., Alsaedi, A., Hayat, T., & Wang, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00543a · Cited by 1,856
Emerging Multifunctional Metal–Organic Framework Materials
Li, B., Wen, H., Cui, Y., Zhou, W., Qian, G., & Chen, B. (2016) · Advanced Materials · doi:10.1002/adma.201601133 · Cited by 1,587
Two-dimensional metal–organic framework nanosheets: synthesis and applications
Zhao, M., Huang, Y., Peng, Y., Huang, Z., Ma, Q., & Zhang, H. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00268a · Cited by 1,348
Luminescent sensors based on metal-organic frameworks
Zhang, Y., Yuan, S., Day, G., Wang, X., Yang, X., & Zhou, H.-C. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.06.007 · Cited by 1,255
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
Lu, K., He, C., & Lin, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja508679h · Cited by 745
Self-citationOptical Sensing and Imaging of pH Values: Spectroscopies, Materials, and Applications
Steinegger, A., Wolfbeis, O. S., & Borisov, S. M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00451 · Cited by 622
Liu, J.-Q., Luo, Z.-D., Pan, Y., Kumar Singh, A., Trivedi, M., & Kumar, A. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2019.213145 · Cited by 508
Metal-organic frameworks: Challenges and opportunities for ion-exchange/sorption applications
Kumar, P., Pournara, A., Kim, K.-H., Bansal, V., Rapti, S., & Manos, M. J. (2017) · Progress in Materials Science · doi:10.1016/j.pmatsci.2017.01.002 · Cited by 423
Nanoscale metal–organic frameworks for phototherapy of cancer
Lan, G., Ni, K., & Lin, W. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.09.007 · Cited by 420
Self-citationMetal–organic frameworks for biosensing and bioimaging applications
Wang, H.-S. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.08.015 · Cited by 403
MOF based luminescence tuning and chemical/physical sensing
Müller-Buschbaum, K., Beuerle, F., & Feldmann, C. (2015) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2015.03.036 · Cited by 337
Catalytic Zirconium/Hafnium-Based Metal–Organic Frameworks
Rimoldi, M., Howarth, A. J., DeStefano, M. R., Lin, L., Goswami, S., Li, P., Hupp, J. T., & Farha, O. K. (2017) · ACS Catalysis · doi:10.1021/acscatal.6b02923 · Cited by 332
Nanoscale Metal–Organic Frameworks for Ratiometric Oxygen Sensing in Live Cells
Xu, R., Wang, Y., Duan, X., Lu, K., Micheroni, D., Hu, A., & Lin, W. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b13458 · Cited by 319
Self-citationRatiometric photoluminescence sensing based on Ti3C2MXene quantum dots as an intracellular pH sensor
Chen, X., Sun, X., Xu, W., Pan, G., Zhou, D., Zhu, J., Wang, H., Bai, X., Dong, B., & Song, H. (2018) · Nanoscale · doi:10.1039/c7nr06958h · Cited by 316
Beg, S., Rahman, M., Jain, A., Saini, S., Midoux, P., Pichon, C., Ahmad, F. J., & Akhter, S. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.10.001 · Cited by 284
Metal-Organic Framework (MOF)-Based Drug Delivery
Cao, J., Li, X., & Tian, H. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190618152518 · Cited by 282
Endogenous Hydrogen Sulfide-Triggered MOF-Based Nanoenzyme for Synergic Cancer Therapy
Li, Y., Zhou, J., Wang, L., & Xie, Z. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c08659 · Cited by 125
Kwon, H., Kim, M., Meany, B., Piao, Y., Powell, L. R., & Wang, Y. (2015) · The Journal of Physical Chemistry C · doi:10.1021/jp509546d · Cited by 110
Unlocking the NIR‐II AIEgen for High Brightness through Intramolecular Electrostatic Locking
Wang, X., Yang, X., Jiang, G., Hu, Z., Liao, T., Wang, G., Zhang, X., He, X., Zhang, J., Zhang, J., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202404142 · Cited by 44
Metadata
- Authors
- He, C., Lu, K., & Lin, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-25
- Volume
- 136
- Issue
- 35
- Pages
- 12253-12256
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2330395753
- Cited by
- 294
- References
- 35
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
