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Nanoscale Metal–Organic Frameworks Stabilize Bacteriochlorins for Type I and Type II Photodynamic Therapy
Abstract
Herein we report the design of a bacteriochlorin-based nanoscale metal–organic framework, Zr-TBB, for highly effective photodynamic therapy via both type I and type II mechanisms. The framework of Zr-TBB stabilizes 5,10,15,20-tetra( p -benzoato)bacteriochlorin (TBB) ligands toward oxygen and light via geometrical constraint. Upon 740 nm light irradiation, Zr-TBB efficiently generates various reactive oxygen species, including singlet oxygen, superoxide anion, hydrogen peroxide, and hydroxyl radicals, to afford superb antitumor efficacy on mouse models of breast and colon cancers, with cure rates of 40% and 60%, respectively.
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Citations
Cited by
Conquering the Hypoxia Limitation for Photodynamic Therapy
Wan, Y., Fu, L., Li, C., Lin, J., & Huang, P. (2021) · Advanced Materials · doi:10.1002/adma.202103978 · Cited by 705
Type I Photosensitizers Revitalizing Photodynamic Oncotherapy
Chen, D., Xu, Q., Wang, W., Shao, J., Huang, W., & Dong, X. (2021) · Small · doi:10.1002/smll.202006742 · Cited by 482
Phototherapy in cancer treatment: strategies and challenges
Cai, Y., Chai, T., Nguyen, W., Liu, J., Xiao, E., Ran, X., Ran, Y., Du, D., Chen, W., & Chen, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02140-y · Cited by 453
BODIPY‐Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen
Teng, K., Chen, W., Niu, L., Fang, W., Cui, G., & Yang, Q. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202106748 · Cited by 445
Teng, K.-X., Niu, L.-Y., & Yang, Q.-Z. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c11868 · Cited by 409
Metadata
- Authors
- Luo, T., Ni, K., Culbert, A., Lan, G., Li, Z., Jiang, X., Kaufmann, M., & Lin, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-04-04
- Volume
- 142
- Issue
- 16
- Pages
- 7334-7339
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W3014867623
- Cited by
- 210
- References
- 0
- FWCI
- 15.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Luo, T., Ni, K., Culbert, A., Lan, G., Li, Z., Jiang, X., Kaufmann, M., & Lin, W. (2020). Nanoscale Metal–Organic Frameworks Stabilize Bacteriochlorins for Type I and Type II Photodynamic Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.0c02129
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