The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy
Abstract
The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop an oxygen-independent supramolecular photodynamic agent that produces hydroxyl radical ( • OH) by oxidizing water in the presence of intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as the electron donor and coassembled with perylene diimide as the electron acceptor to form the quadruple hydrogen-bonded supramolecular photodynamic agent. Detailed mechanism studies reveal that intermolecular electron transfer and charge separation upon light irradiation result in an efficient generation of radical ion pairs. Under oxygen-free conditions, the cationic radicals directly oxidize water to generate highly cytotoxic • OH, and the anionic radicals transfer electrons to pyruvic acid, realizing the catalytic cycle. Thus, this photodynamic agent exhibited superb photocytotoxicity even under severe hypoxic environments and excellent in vivo antitumor efficacy on HeLa-bearing mouse models. This work provides a strategy for constructing oxygen-independent photodynamic agents, which opens up an avenue for effective PDT against hypoxic tumors.
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Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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Photodynamic therapy of cancer: An update
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Reversible Polymers Formed from Self-Complementary Monomers Using Quadruple Hydrogen Bonding
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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
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Conquering the Hypoxia Limitation for Photodynamic Therapy
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Cited by
Yang, M., Ou, X., Zhang, J., Sun, J., Kwok, R. T. K., Lam, J. W. Y., Fan, J., & Tang, B. Z. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202411838 · Cited by 42
Zhu, Y., Lai, H., Gu, Y., Wei, Z., Chen, L., Lai, X., Han, L., Tan, P., Pu, M., Xiao, F., et al. (2024) · Advanced Science · doi:10.1002/advs.202307569 · Cited by 36
Metadata
- Authors
- Teng, K.-X., Niu, L.-Y., & Yang, Q.-Z.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-02-13
- Volume
- 145
- Issue
- 7
- Pages
- 4081-4087
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W4320485594
- Cited by
- 409
- References
- 44
- FWCI
- 64.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Teng, K.-X., Niu, L.-Y., & Yang, Q.-Z. (2023). Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.2c11868
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
