The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Defect Engineering Enables Synergistic Action of Enzyme-Mimicking Active Centers for High-Efficiency Tumor Therapy
Abstract
Perusing redox nanozymes capable of disrupting cellular homeostasis offers new opportunities to develop cancer-specific therapy, but remains challenging, because most artificial enzymes lack enzyme-like scale and configuration. Herein, for the first time, we leverage a defect engineering strategy to develop a simple yet efficient redox nanozyme by constructing enzyme-mimicking active centers and investigated its formation and catalysis mechanism thoroughly. Specifically, the partial Fe doping in MoO x (donated as Fe-MoO v ) was demonstrated to activate structure reconstruction with abundant defect site generation, including Fe substitution and oxygen vacancy (OV) defects, which significantly enable the binding capacity and catalytic activity of Fe-MoO v nanozymes in a synergetic fashion. More intriguingly, plenty of delocalized electrons appear due to Fe-facilitated band structure reconstruction, directly contributing to the remarkable surface plasmon resonance effect in the near-infrared (NIR) region. Under NIR-II laser irradiation, the designed Fe-MoO v nanozymes are able to induce substantial disruption of redox and metabolism homeostasis in the tumor region via enzyme-mimicking cascade reactions, thus significantly augmenting therapeutic effects. This study that takes advantage of defect engineering offers new insights into developing high-efficiency redox nanozymes.
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Cites
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Cited by
Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing
Liu, Y., Xu, B., Lu, M., Li, S., Guo, J., Chen, F., Xiong, X., Yin, Z., Liu, H., & Zhou, D. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.10.023 · Cited by 292
Strategies for enhancing cancer chemodynamic therapy performance
Jana, D., & Zhao, Y. (2022) · Exploration · doi:10.1002/exp.20210238 · Cited by 284
Defect engineering in nanozymes
Wu, Y., Xu, W., Jiao, L., Tang, Y., Chen, Y., Gu, W., & Zhu, C. (2022) · Materials Today · doi:10.1016/j.mattod.2021.10.032 · Cited by 269
Metadata
- Authors
- Yu, B., Wang, W., Sun, W., Jiang, C., & Lu, L.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-06-04
- Volume
- 143
- Issue
- 23
- Pages
- 8855-8865
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W3198435714
- Cited by
- 331
- References
- 45
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, B., Wang, W., Sun, W., Jiang, C., & Lu, L. (2021). Defect Engineering Enables Synergistic Action of Enzyme-Mimicking Active Centers for High-Efficiency Tumor Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.1c03510
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