The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Molecular Imprinting on Inorganic Nanozymes for Hundred-fold Enzyme Specificity
Abstract
Enzyme-mimicking nanomaterials (nanozymes) are more cost-effective and robust than protein enzymes, but they lack specificity. Herein, molecularly imprinted polymers were grown on Fe 3 O 4 nanozymes with peroxidase-like activity to create substrate binding pockets. Electron microscopy confirmed a shell of nanogel. By imprinting with an adsorbed substrate, moderate specificity was achieved with neutral monomers. Further introducing charged monomers led to nearly 100-fold specificity for the imprinted substrate over the nonimprinted compared to that of bare Fe 3 O 4 . Selective substrate binding was further confirmed by isothermal titration calorimetry. The same method was also successfully applied for imprinting on gold nanoparticles (peroxidase mimics) and nanoceria (oxidase mimics). Molecular imprinting furthers the functional enzyme mimicking aspect of nanozymes, and such hybrid materials will find applications in biosensor development, separation, environmental remediation, and drug delivery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles
Gao, L., Zhuang, J., Nie, L., Zhang, J., Zhang, Y., Gu, N., Wang, T., Feng, J., Yang, D., Perrett, S., et al. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.260 · Cited by 7,483
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Wulff, G. (1995) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199518121 · Cited by 2,373
Molecularly Imprinted Polymers and Their Use in Biomimetic Sensors
Haupt, K., & Mosbach, K. (2000) · Chemical Reviews · doi:10.1021/cr990099w · Cited by 2,286
Chen, L., Xu, S., & Li, J. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00084a · Cited by 1,753
Superoxide dismutase mimetic properties exhibited by vacancy engineered ceria nanoparticles
Korsvik, C., Patil, S., Seal, S., & Self, W. T. (2007) · Chemical Communications · doi:10.1039/b615134e · Cited by 1,278
Catalytically Active Nanomaterials: A Promising Candidate for Artificial Enzymes
Lin, Y., Ren, J., & Qu, X. (2014) · Accounts of Chemical Research · doi:10.1021/ar400250z · Cited by 1,252
Nanoceria exhibit redox state-dependent catalase mimetic activity
Pirmohamed, T., Dowding, J. M., Singh, S., Wasserman, B., Heckert, E., Karakoti, A. S., King, J. E. S., Seal, S., & Self, W. T. (2010) · Chemical Communications · doi:10.1039/b922024k · Cited by 1,214
Oxidase‐Like Activity of Polymer‐Coated Cerium Oxide Nanoparticles
Asati, A., Santra, S., Kaittanis, C., Nath, S., & Perez, J. M. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805279 · Cited by 1,161
Pharmacological potential of cerium oxide nanoparticles
Celardo, I., Pedersen, J. Z., Traversa, E., & Ghibelli, L. (2011) · Nanoscale · doi:10.1039/c0nr00875c · Cited by 1,151
Xu, C., & Qu, X. (2014) · NPG Asia Materials · doi:10.1038/am.2013.88 · Cited by 1,133
Liu, J., & Lu, Y. (2006) · Nature Protocols · doi:10.1038/nprot.2006.38 · Cited by 1,126
Self-citationChen, Z., Yin, J.-J., Zhou, Y.-T., Zhang, Y., Song, L., Song, M., Hu, S., & Gu, N. (2012) · ACS Nano · doi:10.1021/nn300291r · Cited by 940
Jv, Y., Li, B., & Cao, R. (2010) · Chemical Communications · doi:10.1039/c0cc02698k · Cited by 936
The Catalytic Activity of “Naked” Gold Particles
Comotti, M., Della Pina, C., Matarrese, R., & Rossi, M. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200460446 · Cited by 824
Magnetoferritin nanoparticles for targeting and visualizing tumour tissues
Fan, K., Cao, C., Pan, Y., Lu, D., Yang, D., Feng, J., Song, L., Liang, M., & Yan, X. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.90 · Cited by 753
Self-Catalyzed, Self-Limiting Growth of Glucose Oxidase-Mimicking Gold Nanoparticles
Luo, W., Zhu, C., Su, S., Li, D., He, Y., Huang, Q., & Fan, C. (2010) · ACS Nano · doi:10.1021/nn102592h · Cited by 650
Nanozymes in bionanotechnology: from sensing to therapeutics and beyond
Wang, X., Hu, Y., & Wei, H. (2016) · Inorganic Chemistry Frontiers · doi:10.1039/c5qi00240k · Cited by 609
Guo, Y., Deng, L., Li, J., Guo, S., Wang, E., & Dong, S. (2011) · ACS Nano · doi:10.1021/nn1029586 · Cited by 590
Philipse, A. P., van Bruggen, M. P. B., & Pathmamanoharan, C. (1994) · Langmuir · doi:10.1021/la00013a014 · Cited by 568
Surface modification of nanozymes
Liu, B., & Liu, J. (2017) · Nano Research · doi:10.1007/s12274-017-1426-5 · Cited by 543
Self-citationMulticopper Laccase Mimicking Nanozymes with Nucleotides as Ligands
Liang, H., Lin, F., Zhang, Z., Liu, B., Jiang, S., Yuan, Q., & Liu, J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b15124 · Cited by 537
Self-citationMolecular imprinted polymers for separation science: A review of reviews
Cheong, W. J., Yang, S. H., & Ali, F. (2013) · Journal of Separation Science · doi:10.1002/jssc.201200784 · Cited by 507
Nano‐Gold as Artificial Enzymes: Hidden Talents
Lin, Y., Ren, J., & Qu, X. (2014) · Advanced Materials · doi:10.1002/adma.201400238 · Cited by 479
Equilibrium swelling and kinetics of pH-responsive hydrogels: models, experiments, and simulations
De, S. K., Aluru, N. R., Johnson, B., Crone, W. C., Beebe, D. J., & Moore, J. (2002) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2002.803281 · Cited by 459
Fan, K., Wang, H., Xi, J., Liu, Q., Meng, X., Duan, D., Gao, L., & Yan, X. (2017) · Chemical Communications · doi:10.1039/c6cc08542c · Cited by 458
Self‐Assembly of Multi‐nanozymes to Mimic an Intracellular Antioxidant Defense System
Huang, Y., Liu, Z., Liu, C., Ju, E., Zhang, Y., Ren, J., & Qu, X. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201600868 · Cited by 436
Liang, M., Fan, K., Pan, Y., Jiang, H., Wang, F., Yang, D., Lu, D., Feng, J., Zhao, J., Yang, L., et al. (2013) · Analytical Chemistry · doi:10.1021/ac302781r · Cited by 417
Wang, N., Zhu, L., Wang, D., Wang, M., Lin, Z., & Tang, H. (2010) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2009.11.001 · Cited by 412
Bioapplications for Molecularly Imprinted Polymers
Schirhagl, R. (2014) · Analytical Chemistry · doi:10.1021/ac401251j · Cited by 372
Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization
Zheng, X., Liu, Q., Jing, C., Li, Y., Li, D., Luo, W., Wen, Y., He, Y., Huang, Q., Long, Y., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201105121 · Cited by 348
Wulff, G., & Liu, J. (2012) · Accounts of Chemical Research · doi:10.1021/ar200146m · Cited by 333
Self-citationIntegrated Nanozymes with Nanoscale Proximity for in Vivo Neurochemical Monitoring in Living Brains
Cheng, H., Zhang, L., He, J., Guo, W., Zhou, Z., Zhang, X., Nie, S., & Wei, H. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b00975 · Cited by 324
Self-citationWang, S., Chen, W., Liu, A., Hong, L., Deng, H., & Lin, X. (2012) · ChemPhysChem · doi:10.1002/cphc.201100906 · Cited by 298
Elastic Modulus and Equilibrium Swelling of Polyelectrolyte Gels
Rubinstein, M., Colby, R. H., Dobrynin, A. V., & Joanny, J.-F. (1996) · Macromolecules · doi:10.1021/ma9511917 · Cited by 279
Nanozymes: an emerging field bridging nanotechnology and biology
Gao, L., & Yan, X. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5044-3 · Cited by 275
Golub, E., Albada, H. B., Liao, W.-C., Biniuri, Y., & Willner, I. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.5b09457 · Cited by 264
Liu, B., Huang, Z., & Liu, J. (2016) · Nanoscale · doi:10.1039/c6nr02730j · Cited by 260
Self-citationLiu, Y., Purich, D. L., Wu, C. S., Wu, Y., Chen, T., Cui, C., Zhang, L., Cansız, S., Hou, W., Wang, Y., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b08533 · Cited by 141
Liu, J., & Wulff, G. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200352770 · Cited by 137
Self-citationMorawski, B., Quan, S., & Arnold, F. H. (2001) · Biotechnology and Bioengineering · doi:10.1002/bit.1149 · Cited by 135
TiO2 nanotube arrays: intrinsic peroxidase mimetics
Zhang, L., Han, L., Hu, P., Wang, L., & Dong, S. (2013) · Chemical Communications · doi:10.1039/c3cc46163g · Cited by 132
Single Nanoparticle to 3D Supercage: Framing for an Artificial Enzyme System
Cai, R., Yang, D., Peng, S., Chen, X., Huang, Y., Liu, Y., Hou, W., Yang, S., Liu, Z., & Tan, W. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b09337 · Cited by 125
Gao, N., Dong, K., Zhao, A., Sun, H., Wang, Y., Ren, J., & Qu, X. (2016) · Nano Research · doi:10.1007/s12274-016-1000-6 · Cited by 121
Shen, X., Zhu, L., Huang, C., Tang, H., Yu, Z., & Deng, F. (2009) · Journal of Materials Chemistry · doi:10.1039/b900196d · Cited by 97
Joseph, K., Dave, N., & Liu, J. (2011) · ACS Applied Materials & Interfaces · doi:10.1021/am101068c · Cited by 87
Self-citationAdvancements in nanosensors using plastic antibodies
Volkert, A. A., & Haes, A. J. (2013) · The Analyst · doi:10.1039/c3an01725g · Cited by 81
Molecular Imprinting for Substrate Selectivity and Enhanced Activity of Enzyme Mimics
Zhang, Z., Liu, B., & Liu, J. (2016) · Small · doi:10.1002/smll.201602730 · Cited by 80
Self-citationShen, X., Zhu, L., Wang, N., Zhang, T., & Tang, H. (2013) · Catalysis Today · doi:10.1016/j.cattod.2013.07.011 · Cited by 59
Effects of phthalic anhydride modification on horseradish peroxidase stability and activity
O'Brien, A. M., SMITH, A. T., & Ó’Fágáin, C. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10462 · Cited by 42
Cited by
Nanozymes: A clear definition with fuzzy edges
Wei, H., Gao, L., Fan, K., Liu, J., He, J., Qu, X., Dong, S., Wang, E., & Yan, X. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101269 · Cited by 580
Self-citationEnzyme Mimicry for Combating Bacteria and Biofilms
Chen, Z., Wang, Z., Ren, J., & Qu, X. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00011 · Cited by 499
Nanozymes: Activity origin, catalytic mechanism, and biological application
Yang, W., Yang, X., Zhu, L., Chu, H., Li, X., & Xu, W. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214170 · Cited by 470
Nanozyme for tumor therapy: Surface modification matters
Tang, G., He, J., Liu, J., Yan, X., & Fan, K. (2021) · Exploration · doi:10.1002/exp.20210005 · Cited by 441
Self-citationMetal–organic framework based nanozymes: promising materials for biochemical analysis
Niu, X., Li, X., Lyu, Z., Pan, J., Ding, S., Ruan, X., Zhu, W., Du, D., & Lin, Y. (2020) · Chemical Communications · doi:10.1039/d0cc04890a · Cited by 328
Metadata
- Authors
- Zhang, Z., Zhang, X., Liu, B., & Liu, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-04-05
- Volume
- 139
- Issue
- 15
- Pages
- 5412-5419
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2598282456
- Cited by
- 666
- References
- 50
- FWCI
- 29.25
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
