The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Photostable Ratiometric Pdot Probe for in Vitro and in Vivo Imaging of Hypochlorous Acid
Open accessAbstract
Developing probes for the detection of reactive oxygen species (ROS), a hallmark of many pathophysiological process, is imperative to both understanding the precise roles of ROS in many life-threatening diseases and optimizing therapeutic interventions. We herein report an all-in-one fluorescent semiconducting polymer based far-red to near-infrared (NIR) Pdot nanoprobe for the ratiometric detection of hypochlorous acid (HOCl). The fabrication takes the advantage of flexible polymer design by incorporating target-sensitive and target-inert fluorophores into a single conjugated polymer to avoid leakage or differential photobleaching problems existed in other nanoprobes. The obtained nanoprobe has improved performance in HOCl sensing, such as high brightness, ideal far-red to NIR optical window, excellent photostability, self-referenced ratiometric response, fast response, and high selectivity. The dual-emission property allows the sensitive imaging of HOCl fluctuations produced in living macrophage cells and peritonitis of living mice with high contrast. This study not only provides a powerful and promising nanoprobe to be potentially used in the investigations of in situ HOCl status of diseases in living systems but also puts forward the design strategy of a new category of ratiometric fluorescent probes facilitating precise and reliable measurement in biological systems.
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Association of reactive oxygen species levels and radioresistance in cancer stem cells
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Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Fang, F. C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1004 · Cited by 1,676
Molecular mechanisms of N-acetylcysteine actions
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Multicolor Fluorescent Semiconducting Polymer Dots with Narrow Emissions and High Brightness
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Cited by
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Liu, M., Zhang, Z., Yang, Y., & Chan, Y. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202011914 · Cited by 134
Tang, Y., Li, Y., Lu, X., Hu, X., Zhao, H., Hu, W., Lu, F., Fan, Q., & Huang, W. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201807376 · Cited by 96
Tsai, W.-K., Wang, C.-I., Liao, C.-H., Yao, C.-N., Kuo, T.-J., Liu, M.-H., Hsu, C.-P., Lin, S.-Y., Wu, C.-Y., Pyle, J. R., et al. (2019) · Chemical Science · doi:10.1039/c8sc03510e · Cited by 79
Unambiguous Detection of Elevated Levels of Hypochlorous Acid in Double Transgenic AD Mouse Brain
Samanta, S., & Govindaraju, T. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00554 · Cited by 57
Metadata
- Authors
- Wu, L., Wu, I.-C., DuFort, C. C., Carlson, M. A., Wu, X., Chen, L., Kuo, C.-T., Qin, Y., Yu, J., Hingorani, S. R., & Chiu, D. T.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-05-11
- Volume
- 139
- Issue
- 20
- Pages
- 6911-6918
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2610431184
- Cited by
- 349
- References
- 8
- FWCI
- 20.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, L., Wu, I.-C., DuFort, C. C., Carlson, M. A., Wu, X., Chen, L., Kuo, C.-T., Qin, Y., Yu, J., Hingorani, S. R., & Chiu, D. T. (2017). Photostable Ratiometric Pdot Probe for in Vitro and in Vivo Imaging of Hypochlorous Acid. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.7b01545
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