The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach
Open accessAbstract
A major challenge in photodynamic cancer therapy (PDT) is avoiding PDT-induced hypoxia, which can lead to cancer recurrence and progression through activation of various angiogenic factors and significantly reduce treatment outcomes. Reported here is an acetazolamide (AZ)-conjugated BODIPY photosensitizer (AZ-BPS) designed to mitigate the effects of PDT-based hypoxia by combining the benefits of anti-angiogenesis therapy with PDT. AZ-BPS showed specific affinity to aggressive cancer cells (MDA-MB-231 cells) that overexpress carbonic anhydrase IX (CAIX). It displayed enhanced photocytotoxicity compared to a reference compound, BPS, which is an analogous PDT agent that lacks an acetazolamide unit. AZ-BPS also displayed an enhanced in vivo efficacy in a xenograft mouse tumor regrowth model relative to BPS, an effect attributed to inhibition of tumor angiogenesis by both PDT-induced ROS generation and CAIX knockdown. AZ-BPS was evaluated successfully in clinical samples collected from breast cancer patients. We thus believe that the combined approach described here represents an attractive therapeutic approach to targeting CAIX-overexpressing tumors.
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Cites
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
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Metadata
- Authors
- Jung, H. S., Han, J., Shi, H., Koo, S., Singh, H., Kim, H.-J., Sessler, J. L., Lee, J. Y., Kim, J.-H., & Kim, J. S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-05-10
- Volume
- 139
- Issue
- 22
- Pages
- 7595-7602
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2610893008
- Cited by
- 323
- References
- 44
- FWCI
- 27.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Jung, H. S., Han, J., Shi, H., Koo, S., Singh, H., Kim, H.-J., Sessler, J. L., Lee, J. Y., Kim, J.-H., & Kim, J. S. (2017). Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.7b02396
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