An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Zhang, Zhijun; Xu, Wenhan; Kang, Miaomiao; Wen, Haifei; Guo, Heng; Zhang, Pengfei; Xi, Lei; Li, Kai; Wang, Lei; Wang, Dong; Tang, Ben Zhong

doi:10.1002/adma.202003210

Cited by 437Nanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies

An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Zhang, Zhijun, Xu, Wenhan, Kang, Miaomiao, Wen, Haifei, Guo, Heng, Zhang, Pengfei, Xi, Lei, Li, Kai +3 more·2020·Advanced Materials

DOI 10.1002/adma.202003210

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Abstract

Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, the optimum use of dissipated energy through both radiative and nonradiative pathways is definitely appealing, yet a significantly challenging task. To the best of the knowledge, there have been no previous reports on a single molecular species effective at affording all phototheranostic modalities including fluorescence imaging (FLI), photoacoustic imaging (PAI), photothermal imaging (PTI), photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, a simple and highly powerful one‐for‐all phototheranostics based on aggregation‐induced emission (AIE)‐active fluorophores is tactfully designed and constructed. Thanks to its strong electron donor–acceptor interaction and finely modulated intramolecular motion, the AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) fluorescence emission, efficient reactive oxygen species generation, and high photothermal conversion efficiency upon NIR irradiation, indicating the actualization of a balance between radiative and nonradiative energy dissipations. Furthermore, the unprecedented performance on NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT synergistic therapy is demonstrated by the precise tumor diagnosis and complete tumor elimination outcomes. This study thus brings a new insight into the development of superior versatile phototheranostics for practical cancer theranostics.

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Tang et al. demonstrated that introducing thiophene units into conjugated backbones such as TSI and TSSI enhanced electron-donating ability, leading to significant red-shifts in absorption and emission.
“Tang et al. demonstrated that introducing thiophene units into conjugated backbones such as TSI and TSSI enhanced electron-donating ability, leading to significant red-shifts in absorption and emission185.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [185]
Cyano-based configurations significantly narrow the molecular bandgap, shifting absorption and emission from the visible or NIR-I to the NIR-II region.
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Authors: Zhang, Z., Xu, W., Kang, M., Wen, H., Guo, H., Zhang, P., Xi, L., Li, K., Wang, L., Wang, D., & Tang, B. Z.
Affiliations: Shenzhen University (CN)
Hong Kong University of Science and Technology (HK)
Southern University of Science and Technology (CN)
Chinese Academy of Sciences (CN)
Corresponding author: Wang, Dong
Tang, Ben Zhong
ORCID: Zhang, Zhijun
Xu, Wenhan
Kang, Miaomiao
Wen, Haifei
Guo, Heng
Zhang, Pengfei
Xi, Lei
Li, Kai
Wang, Lei
Wang, Dong
Tang, Ben Zhong
Venue: Advanced Materials
Publisher: Wiley
Published: 2020-07-21
Volume: 32
Issue: 36
Pages: e2003210-e2003210
ISSN: 0935-9648 (ISSN-L)
1521-4095
DOI: 10.1002/adma.202003210
OpenAlex: W3045107785
Cited by: 436
References: 45
Citations by year: 2026: 34 · 2025: 55 · 2024: 94 · 2023: 78 · 2022: 79 · 2021: 86 · 2020: 10
FWCI: 19.88
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Advanced Materials (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Keywords: phototheranostics, aggregation-induced emission, NIR-II fluorescence imaging, photoacoustic imaging, photothermal imaging, photodynamic therapy, photothermal therapy, synergistic cancer therapy, donor-acceptor interactions, reactive oxygen species generation, tumor diagnosis, multimodal imaging
MeSH terms: Neoplasms, Phototherapy, Optical Imaging, Multimodal Imaging

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An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

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