The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide
Open accessAbstract
Photoacoustic (PA) imaging is an emerging imaging modality that utilizes optical excitation and acoustic detection to enable high resolution at centimeter depths. The development of activatable PA probes can expand the utility of this technology to allow for detection of specific stimuli within live-animal models. Herein, we report the design, development, and evaluation of a series of Acoustogenic Probe(s) for Nitric Oxide (APNO) for the ratiometric, analyte-specific detection of nitric oxide (NO) in vivo. The best probe in the series, APNO-5, rapidly responds to NO to form an N-nitroso product with a concomitant 91 nm hypsochromic shift. This property enables ratiometric PA imaging upon selective irradiation of APNO-5 and the corresponding product, tAPNO-5. Moreover, APNO-5 displays the requisite photophysical characteristics for in vivo PA imaging (e.g., high absorptivity, low quantum yield) as well as high biocompatibility, stability, and selectivity for NO over a variety of biologically relevant analytes. APNO-5 was successfully applied to the detection of endogenous NO in a murine lipopolysaccharide-induced inflammation model. Our studies show a 1.9-fold increase in PA signal at 680 nm and a 1.3-fold ratiometric turn-on relative to a saline control.
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Cites
Photoacoustic tomography: In vivo imaging from organelles to organs
Wang, L. V., & Hu, S. (2012) · Science · doi:10.1126/science.1216210 · Cited by 4,331
Nitric oxide and the immune response
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Nitric oxide metabolism and breakdown
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Cited by
Zeng, S., Liu, X., Kafuti, Y. S., Kim, H., Wang, J., Peng, X., Li, H., & Yoon, J. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00799a · Cited by 341
Zhu, T., Ren, N., Liu, X., Dong, Y., Wang, R., Gao, J., Sun, J., Zhu, Y., Wang, L., Fan, C., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202015650 · Cited by 106
Xiao, P., Liang, M., Yang, S., Sun, Y., Li, J., Gu, Z., Zhang, L., Fan, Q., Jiang, X., & Wu, W. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.121993 · Cited by 36
Near-infrared fluorescent Aza-BODIPY dyes: Rational structural design and biomedical imaging
Zhao, B., Liao, L., Zhu, Y., Hu, Z., & Wu, F. (2023) · Journal of Luminescence · doi:10.1016/j.jlumin.2023.120099 · Cited by 31
Chen, J., Chen, L., Fang, Y., Zeng, F., & Wu, S. (2022) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2021.100570 · Cited by 29
Metadata
- Authors
- Reinhardt, C. J., Zhou, E. Y., Jorgensen, M. D., Partipilo, G., & Chan, J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-01-09
- Volume
- 140
- Issue
- 3
- Pages
- 1011-1018
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2784082116
- Cited by
- 209
- References
- 5
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Reinhardt, C. J., Zhou, E. Y., Jorgensen, M. D., Partipilo, G., & Chan, J. (2018). A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.7b10783
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