Probing the Intracellular Dynamics of Nitric Oxide and Hydrogen Sulfide Using an Activatable NIR II Fluorescence Reporter
Abstract
Understanding the complex interplay among gasotransmitters is of great significance but remains technically challenging. In this study, we present the design and synthesis of a dually responsive BOD‐NH‐SC reporter for probing the dynamic and alternating existence of NO and H 2 S in living cells. This designed reporter can repeatedly cycle S‐nitrosation and transnitrosation reactions when successively treated with NO and H 2 S, thus affording the interchange of NIR fluorescence at 645 nm (NO) and NIR II fluorescence at 936 nm (H 2 S). In light of this unique fluorescence alternation between two colors, we synthesized water‐soluble BOD‐NH‐SC dots to visualize the intracellular dynamics of NO and H 2 S. These molecular probes thus provide a toolbox to elucidate the interplaying roles of NO and H 2 S in the complex interaction networks of various signal transduction pathways.
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Installing orthogonal reactive motifs on the BODIPY scaffold achieves ratiometric and reversible response behavior.
“This design highlighted the principle of installing orthogonal reactive motifs on the BODIPY scaffold to achieve ratiometric and reversible response behavior.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [158]
BOD-NH-SC enabled precise monitoring of the alternating presence of NO and H2S in living cells.
“enabling precise monitoring of the alternating presence of NO and H2S in living cells.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [158]
BOD-NH-SC exhibited reversible fluorescence switching between NIR-I (655 nm) and NIR-II (936 nm) emissions.
“The probe exhibited reversible fluorescence switching between NIR-I (655 nm) and NIR-II (936 nm) emissions”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [158]
Zhao et al. developed a dual-stimulus-responsive probe BOD-NH-SC integrating an N-methyl-2-methoxyaniline moiety for selective NO recognition and a 4-nitrophenylethanol-substituted BODIPY group for H2S detection.
“Zhao et al. developed a dual-stimulus-responsive probe (BOD-NH-SC) that integrated an N-methyl-2-methoxyaniline moiety for selective NO recognition and a 4-nitrophenylethanol-substituted BODIPY group for H2S detection158.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [158]
Cites
Nitric oxide synthases: Roles, tolls, and controls
Nathan, C., & Xie, Q. W. (1994) · Cell · doi:10.1016/0092-8674(94)90266-6 · Cited by 2,920 · see citing works
Yang, G., Wu, L., Jiang, B., Yang, W., Qi, J., Cao, K., Meng, Q., Mustafa, A. K., Mu, W., Zhang, S., et al. (2008) · Science · doi:10.1126/science.1162667 · Cited by 2,310 · see citing works
Self-citationLuminescent Chemodosimeters for Bioimaging
Yang, Y., Zhao, Q., Feng, W., & Li, F. (2012) · Chemical Reviews · doi:10.1021/cr2004103 · Cited by 2,236 · see citing works
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Li, J., & Pu, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,171 · see citing works
Self-citationLin, V., Chen, W., Xian, M., & Chang, C. J. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00298a · Cited by 1,041 · see citing works
Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications
Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037 · see citing works
Fluorescent Probes for Sensing and Imaging within Specific Cellular Organelles
Zhu, H., Fan, J., Du, J., & Peng, X. (2016) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00292 · Cited by 987 · see citing works
Design strategies of fluorescent probes for selective detection among biothiols
Niu, L., Chen, Y., Zheng, H.-R., Wu, L., Tung, C., & Yang, Q. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00152h · Cited by 872 · see citing works
Specific light-up bioprobes based on AIEgen conjugates
Liang, J., Tang, B. Z., & Liu, B. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00444b · Cited by 762 · see citing works
Protein S-nitrosylation in health and disease: a current perspective
Foster, M. W., Hess, D. T., & Stamler, J. S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.007 · Cited by 752 · see citing works
Redox Biochemistry of Hydrogen Sulfide
Kabil, Ö., & Banerjee, R. V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.128363 · Cited by 745 · see citing works
Coletta, C., Papapetropoulos, A., Erdelyi, K., Olah, G., Módis, K., Panopoulos, P., Asimakopoulou, A., Gerö, D., Sharina, I., Martin, E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202916109 · Cited by 677 · see citing works
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658 · see citing works
Singh, S., Padovani, D., Leslie, R. A., Chiku, T., & Banerjee, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.010868 · Cited by 615 · see citing works
Huang, J., & Pu, K. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202001783 · Cited by 548 · see citing works
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works
Miao, Q., & Pu, K. (2018) · Advanced Materials · doi:10.1002/adma.201801778 · Cited by 539 · see citing works
Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window
Yang, Q., Ma, Z., Wang, H., Zhou, B., Zhu, S., Zhong, Y., Wang, J., Wan, H., Antaris, A., Ma, R., et al. (2017) · Advanced Materials · doi:10.1002/adma.201605497 · Cited by 467 · see citing works
Chiku, T., Padovani, D., Zhu, W., Singh, S., Vitvitsky, V., & Banerjee, R. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808026200 · Cited by 454 · see citing works
Fukuto, J. M., Carrington, S. J., Tantillo, D. J., Harrison, J. G., Ignarro, L. J., Freeman, B. A., Chen, A., & Wink, D. A. (2012) · Chemical Research in Toxicology · doi:10.1021/tx2005234 · Cited by 389 · see citing works
A practical guide to working with H 2 S at the interface of chemistry and biology
Hartle, M. D., & Pluth, M. D. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00212a · Cited by 350 · see citing works
A new gaseous signaling molecule emerges: Cardioprotective role of hydrogen sulfide
Lefer, D. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709010104 · Cited by 346 · see citing works
Filipovic, M. R., Miljkovic, J. L., Nauser, T., Royzen, M., Klos, K., Shubina, T., Koppenol, W. H., Lippard, S. J., & Ivanović-Burmazović, I. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3009693 · Cited by 336 · see citing works
Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near‐Infrared Window Emission
Xu, G., Yan, Q., Lv, X., Zhu, Y. J., Xin, K., Shi, B., Wang, R., Chen, J., Gao, W., Shi, P., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201712528 · Cited by 313 · see citing works
Self-citationChen, W., Pacheco, A., Takano, Y., Day, J. J., Hanaoka, K., & Xian, M. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201604892 · Cited by 294 · see citing works
Zhao, C., Zhang, X., Li, K.-B., Zhu, S., Guo, Z., Zhang, L., Wang, F., Fei, Q., Luo, S., Shi, P., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b03248 · Cited by 282 · see citing works
Self-citationA Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide
Reinhardt, C. J., Zhou, E. Y., Jorgensen, M. D., Partipilo, G., & Chan, J. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b10783 · Cited by 210 · see citing works
Sun, Y., Liu, J., Zhang, H., Huo, Y., Lv, X., Shi, Y., & Guo, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504156a · Cited by 205 · see citing works
Wang, F., Zhu, Y. J., Zhou, L., Pan, L., Cui, Z., Fei, Q., Luo, S., Pan, D., Huang, Q., Wang, R., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201502899 · Cited by 201 · see citing works
Self-citationWu, L., Sun, Y., Sugimoto, K., Luo, Z., Ishigaki, Y., Pu, K., Suzuki, T., Chen, H., & Ye, D. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b10176 · Cited by 183 · see citing works
Teng, L., Song, G., Liu, Y., Han, X., Li, Z., Wang, Y., Huan, S., Zhang, X., & Tan, W. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b05901 · Cited by 180 · see citing works
Shi, B., Ren, N., Gu, L., Xu, G., Wang, R., Zhu, T., Zhu, Y. J., Fan, C., Zhao, C., & Tian, H. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909883 · Cited by 148 · see citing works
Self-citationWang, R., Gu, X., Li, Q., Gao, J., Shi, B., Xu, G., Zhu, T., Tian, H., & Zhao, C. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c06533 · Cited by 145 · see citing works
Self-citationLi, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie · doi:10.1002/ange.201801226 · Cited by 137 · see citing works
Recent developments of fluorescent probes for detection and bioimaging of nitric oxide
Chen, Y. (2020) · Nitric Oxide · doi:10.1016/j.niox.2020.02.002 · Cited by 104 · see citing works
Yi, L., & Xi, Z. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob00332c · Cited by 102 · see citing works
Zhou, Y., Zhang, X., Yang, S., Li, Y., Qing, Z., Zheng, J., Li, J., & Yang, R. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00073 · Cited by 102 · see citing works
Self-citationHuang, J., & Pu, K. (2020) · Angewandte Chemie · doi:10.1002/ange.202001783 · Cited by 99 · see citing works
Zhang, P., Li, J., Li, B., Xu, J., Zeng, F., Lv, J., & Wu, S. (2015) · Chemical Communications · doi:10.1039/c4cc09737h · Cited by 86 · see citing works
Self-citationYong, Q.-C., Cheong, J. L., Hua, F., Deng, L.-W., Khoo, Y. M., Lee, H.-S., Perry, A., Wood, M., Whiteman, M., & Bian, J.-S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3572 · Cited by 85 · see citing works
Fast Reductive Ligation of S‐Nitrosothiols
Wang, H., & Xian, M. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801654 · Cited by 80 · see citing works
Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near‐Infrared Window Emission
Xu, G., Yan, Q., Lv, X., Zhu, Y. J., Xin, K., Shi, B., Wang, R., Chen, J., Gao, W., Shi, P., et al. (2018) · Angewandte Chemie · doi:10.1002/ange.201712528 · Cited by 68 · see citing works
Self-citationHNO Is Produced by the Reaction of NO with Thiols
Suárez, S., Muñoz, M., Álvarez, L., Venâncio, M. F., Rocha, W. R., Bikiel, D. E., Marti, M. A., & Doctorovich, F. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b06968 · Cited by 59 · see citing works
Yang, M., Fan, J., Sun, W. C., Du, J., Long, S., Shao, K., & Peng, X. (2019) · Chemical Communications · doi:10.1039/c9cc04060a · Cited by 45 · see citing works
Chen, W., Pacheco, A., Takano, Y., Day, J. J., Hanaoka, K., & Xian, M. (2016) · Angewandte Chemie · doi:10.1002/ange.201604892 · Cited by 38 · see citing works
Xu, G., Guo, W., Gu, X., Wang, Z., Wang, R., Zhu, T., Tian, H., & Zhao, C. (2020) · CCS Chemistry · doi:10.31635/ccschem.020.201900072 · Cited by 37 · see citing works
Self-citationZuo, Y., Wang, X., Gou, Z., & Lin, W. (2019) · Chemical Communications · doi:10.1039/c9cc08723k · Cited by 33 · see citing works
Wang, F., Zhu, Y. J., Zhou, L., Pan, L., Cui, Z., Fei, Q., Luo, S., Pan, D., Huang, Q., Wang, R., et al. (2015) · Angewandte Chemie · doi:10.1002/ange.201502899 · Cited by 30 · see citing works
Self-citationAugmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide
Nalli, A. D., Bhattacharya, S., Wang, H., Kendig, D. M., Grider, J. R., & Murthy, K. S. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00161.2017 · Cited by 28 · see citing works
Monti, M., Hyseni, I., Pacini, A., Monzani, E., Casella, L., & Morbidelli, L. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.03.025 · Cited by 22 · see citing works
Shi, B., Ren, N., Gu, L., Xu, G., Wang, R., Zhu, T., Zhu, Y. J., Fan, C., Zhao, C., & Tian, H. (2019) · Angewandte Chemie · doi:10.1002/ange.201909883 · Cited by 21 · see citing works
Self-citationFast Reductive Ligation of S‐Nitrosothiols
Wang, H., & Xian, M. (2008) · Angewandte Chemie · doi:10.1002/ange.200801654 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 544 · see citing works
Self-citationRecent progress in the development of fluorescent probes for imaging pathological oxidative stress
Geng, Y., Wang, Z., Zhou, J., Zhu, M., Liu, J., & James, T. D. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00172a · Cited by 359 · see citing works
Fluorescent probes for the detection of disease-associated biomarkers
Dou, W., Han, H., Sedgwick, A. C., Zhu, G.-B., Zang, Y., Yang, X., Yoon, J., James, T. D., Li, J. X., & He, X. (2022) · 中国科学通报:英文版 · doi:10.1016/j.scib.2022.01.014 · Cited by 267 · see citing works
Self-citationActivity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species
Fosnacht, K. G., & Pluth, M. D. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00683 · Cited by 221 · see citing works
Qin, Z., Ren, T., Zhou, H., Zhang, X., He, L., Li, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202201541 · Cited by 140 · see citing works
Activatable NIR-II organic fluorescent probes for bioimaging
Zhang, X., Li, S., Ma, H., Wang, H., Zhang, X., & Zhang, X. (2022) · Theranostics · doi:10.7150/thno.71359 · Cited by 138 · see citing works
Meng, X., Pang, X., Zhang, K., Gong, C., Yang, J., Dong, H., & Zhang, X. (2022) · Small · doi:10.1002/smll.202202035 · Cited by 135 · see citing works
Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing
Jiang, G., Liu, H., Liu, H., Ke, G., Ren, T., Xiong, B., Zhang, X., & Yuan, L. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202315217 · Cited by 127 · see citing works
Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works
Self-citationSun, P., Qu, F., Zhang, C., Cheng, P., Li, X., Shen, Q., Li, D., & Fan, Q. (2022) · Advanced Science · doi:10.1002/advs.202204718 · Cited by 101 · see citing works
Cellular Redox Regulation and Fluorescence Imaging
Li, Y., Liu, G., Cheng, S., Zhang, J., Yao, X., Xie, X., Xu, C., Tang, Y., Wang, X., & Tang, B. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00080 · Cited by 82 · see citing works
Zeng, W., Wu, L., Ishigaki, Y., Harimoto, T., Hu, Y., Sun, Y., Wang, Y., Suzuki, T., Chen, H., & Ye, D. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202111759 · Cited by 79 · see citing works
Recent Progress of Cyanine Fluorophores for NIR‐II Sensing and Imaging
Zhou, H., & Ren, T. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200147 · Cited by 76 · see citing works
Liu, Q., Yang, Z., Su, Y., Zhao, L., & Peng, J. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00548 · Cited by 73 · see citing works
Mitochondria-targeted fluorophore: State of the art and future trends
Ding, Q., Wang, X., Luo, Y., Leng, X., Li, X., Gu, M., & Kim, J. S. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215772 · Cited by 68 · see citing works
Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes
Cabello, M. C., Chen, G., Melville, M. J., Osman, R., Kumar, G., Domaille, D. W., & Lippert, A. R. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00892 · Cited by 67 · see citing works
Wang, N., Lu, X., Wang, J., Han, R., Ma, X., Zhang, B., Zhao, W., & Zhang, J. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.135806 · Cited by 65 · see citing works
Wu, L., Zeng, W., Ishigaki, Y., Zhang, J., Bai, H., Harimoto, T., Suzuki, T., & Ye, D. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202209248 · Cited by 61 · see citing works
Discovering a New Drug Against Acute Kidney Injury by Using a Tailored Photoacoustic Imaging Probe
Zhang, W., Chan, C., Zhang, K.-Y., Qin, H., Yu, B., Xue, Z., Zheng, X., & Tian, J. (2024) · Advanced Materials · doi:10.1002/adma.202311397 · Cited by 53 · see citing works
Yang, Q., Zhou, Y., Tan, L., Xie, C., Luo, K., Li, X., Zeng, M., & Zhou, L. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04640 · Cited by 52 · see citing works
Li, S., Huo, F., & Yin, C. (2021) · Dyes and Pigments · doi:10.1016/j.dyepig.2021.109825 · Cited by 45 · see citing works
Chemical Approaches to Optimize the Properties of Organic Fluorophores for Imaging and Sensing
Jiang, G., Liu, H., Liu, H. S., Ke, G., Ren, T., Xiong, B., Zhang, X., & Yuan, L. (2023) · Angewandte Chemie · doi:10.1002/ange.202315217 · Cited by 45 · see citing works
Liu, Y., Yu, S., An, R., Miao, Y., Jiang, D., Ye, D., Xu, J., & Zhao, W. (2023) · ACS Nano · doi:10.1021/acsnano.3c05825 · Cited by 44 · see citing works
Dong, X., Sun, L., Zhang, Z., Zhu, T., Sun, J., Gao, J., Dong, C., Wang, R., Gu, X., & Zhao, C. (2023) · Science China Chemistry · doi:10.1007/s11426-023-1579-y · Cited by 43 · see citing works
Self-citationA “double-locked” probe for the detection of hydrogen sulfide in a viscous system
Kong, F., Wang, X., Bai, J., Li, X., Yang, C., Li, Y., Xu, K., & Tang, B. (2021) · Chemical Communications · doi:10.1039/d1cc01819a · Cited by 43 · see citing works
Design strategies and applications of smart optical probes in the second near-infrared window
Chang, B., Chen, J., Bao, J., Dong, K., Chen, S., & Cheng, Z. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114637 · Cited by 43 · see citing works
Wang, M., Bai, S., & Zhang, Y. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00502g · Cited by 41 · see citing works
Zhong, Q., Zhang, R., Yang, B., Tian, T., Zhang, K., & Liu, B. (2022) · ACS Sensors · doi:10.1021/acssensors.1c02711 · Cited by 41 · see citing works
Wang, L., Liu, Z., Teng, K., Niu, L., & Yang, Q. (2022) · Chemical Communications · doi:10.1039/d1cc06051a · Cited by 40 · see citing works
Self-citationSun, L., Wu, H., Zhang, Z., Wu, K., Sun, J., Dong, X., Dong, C., Zhao, C., Gu, X., & Qu, D. (2025) · Aggregate · doi:10.1002/agt2.70007 · Cited by 39 · see citing works
Self-citationStimuli-responsive organic small-molecule NIR-II fluorescent probes
Zhang, Z., Mei, A., Wang, W., Xu, K., Wang, M., Chen, P., Shao, J., & Dong, X. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217026 · Cited by 39 · see citing works
Recent advances in colorimetric and fluorometric sensing of neurotransmitters by organic scaffolds
Chemchem, M., Chemchem, A., Aydıner, B., & Seferoğlu, Z. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114820 · Cited by 37 · see citing works
Quan, Y., Fan, L., Shen, H., Wu, B., Kong, S., Luo, Y., Huang, Z., & Ye, X. (2021) · Dyes and Pigments · doi:10.1016/j.dyepig.2021.109897 · Cited by 36 · see citing works
Aggregation-Induced Emission-Active Biomacromolecules: Progress, Challenges, and Opportunities
Hu, R., Wang, J., Qin, A., & Tang, B. Z. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.1c01516 · Cited by 35 · see citing works
Lee, K., Chen, H., Wan, Y., Zhang, Z., Huang, Z., Li, S., & Lee, C. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121753 · Cited by 34 · see citing works
Multi-stimuli-responsive molecular fluorescent probes for bioapplications
Xue, S.-S., Li, Y., Pan, W., Li, N., & Tang, B. (2023) · Chemical Communications · doi:10.1039/d2cc07008a · Cited by 34 · see citing works
Kong, L., Lu, W., Cao, X., Wei, Y., Sun, J., & Wang, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01210c · Cited by 33 · see citing works
Self-citationHu, S., Huang, L., Zhou, L.-Y., Wu, T., Zhao, S., & Zhang, L. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c05333 · Cited by 33 · see citing works
Pan, Y.-H., Chen, X., Dong, L., Shao, N., Niu, L., & Yang, Q. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.06.024 · Cited by 30 · see citing works
Highly selective imaging of intratumoral hydrogen sulfide by NIR-II emissive fluorescent probes
Wang, Z., Li, X., Sun, X., Zhang, X., He, C., Li, Y., Lu, F., Lü, X., & Fan, Q. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.133627 · Cited by 28 · see citing works
Liu, B., Zhang, X., Li, J., Yao, S., Lu, Y., Cao, B., & Liu, Z. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c22575 · Cited by 27 · see citing works
Self-citationWang, W., Yang, T., Zhang, Q., Lu, K., Zheng, Z., Tian, C., Ping, J., Qi, B., & Wu, S. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04896 · Cited by 27 · see citing works
Activatable Molecular Probes With Clinical Promise for NIR‐II Fluorescent Imaging
Chen, Z., Zhou, Y., Li, L., Ma, W., Li, Y., & Yang, Z. (2025) · Small · doi:10.1002/smll.202411787 · Cited by 26 · see citing works
Recent advances in activatable NIR-II organic fluorophores for biomedical applications
Xu, Y., Zhang, P., Gao, A., Xu, R., Wang, Z., Shen, Q., Zhao, Z., Meng, L., & Dang, D. (2022) · Materials Chemistry Frontiers · doi:10.1039/d2qm01120d · Cited by 26 · see citing works
Deng, G., Zhang, S., Peng, X., Ma, G., Liu, L., Tan, Y., Gong, P., Tang, B. Z., Cai, L., & Zhang, P. (2024) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.4c00011 · Cited by 25 · see citing works
Luminescent probes for detecting and bioimaging of nitric oxide and carbon monoxide
Gan, G., Ma, T., Zhang, G., He, K., & Hu, J. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117340 · Cited by 25 · see citing works
Gao, J., Wang, R., Yin, K., Zhu, T., Sun, J., Dong, C., Dong, X., Zhao, M., Gu, X., & Zhao, C. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.143102 · Cited by 24 · see citing works
Self-citationMolecular fluorescent sensors for in vivo imaging
Adair, L. D., & New, E. J. (2023) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2023.102973 · Cited by 22 · see citing works
Ye, J., Wang, D., Yao, H., Cong, H., Shen, Y., & Yu, B. (2025) · Small · doi:10.1002/smll.202409722 · Cited by 22 · see citing works
Niu, H., Mi, X., Hua, X., Zhang, Y., Zhai, Y., Qin, F., Ye, Y., & Zhao, Y. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.339341 · Cited by 21 · see citing works
Wang, Y., Li, S., Zhu, X., Shi, X., Liu, X., & Zhang, H. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339670 · Cited by 21 · see citing works
Self-citationZeng, W., Wu, L., Ishigaki, Y., Harimoto, T., Hu, Y., Sun, Y., Wang, Y., Suzuki, T., Chen, H., & Ye, D. (2021) · Angewandte Chemie · doi:10.1002/ange.202111759 · Cited by 21 · see citing works
Fan, N., Zhou, Y., Wu, L., Wang, X., Li, P., Liu, Z., Zhang, W., Zhang, W., & Tang, B. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c00903 · Cited by 21 · see citing works
Lei, S., Jiang, K., Zhang, C., Sun, W., Pan, Y., Wang, D., Huang, P., & Lin, J. (2023) · Research · doi:10.34133/research.0286 · Cited by 19 · see citing works
Recent advances in NIR small molecule activable probes for imaging and therapy
Ye, J., Wang, D., Wang, Z., Cao, M., Shen, Y., Yu, B., & Cong, H. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216904 · Cited by 18 · see citing works
A novel NIR fluorescent probe for visualizing hydrogen sulfide in Alzheimer's disease
Hong, S., Gan, Y., Liu, D., Yu, T., Zhou, H., Li, H., Liu, F., & Yin, P. (2024) · The Analyst · doi:10.1039/d4an00819g · Cited by 18 · see citing works
Organic small-molecule NIR-II fluorophores for tumor phototheranostics
Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works
“Zhao et al. developed a dual-stimulus-responsive probe (BOD-NH-SC) that integrated an N-methyl-2-methoxyaniline moiety for selective NO recognition and a 4-nitrophenylethanol-substituted BODIPY group for H 2 S detection 158 .”
Baruah, P., Padhi, D., Moorthy, H., Ramesh, M., & Govindaraju, T. (2025) · RSC Chemical Biology · doi:10.1039/d5cb00006h · Cited by 16 · see citing works
Mao, Y., Zhang, W., Wang, X., Li, P., & Tang, B. (2026) · Chemical Society Reviews · doi:10.1039/d5cs00947b · Cited by 17 · see citing works
Sun, L., Zheng, Z., Zhang, Z., Wu, K., Wu, H., Liu, H., Wang, M., Zhao, C., & Gu, X. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04848 · Cited by 16 · see citing works
Self-citationQin, Z., Ren, T., Zhou, H., Zhang, X., He, L., Li, Z., Zhang, X., & Yuan, L. (2022) · Angewandte Chemie · doi:10.1002/ange.202201541 · Cited by 15 · see citing works
Dual‐Responsive Fluorescent Probes: Advances in Biosensing, Diagnosis and Therapy
Liu, J., Wu, L., Zhu, Z., Yan, C., Zhang, Y., Yang, T., Xu, S. S., Yang, H., Liu, S., Tang, W., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202515602 · Cited by 14 · see citing works
Wang, S., Zhou, M., Chen, L., Ren, M., Bu, Y., Wang, J., Yu, Z., Zhu, X., Zhang, J., Wang, L., et al. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00488 · Cited by 14 · see citing works
Self-citationSun, L., Dong, X., Gao, J., Zhu, T., Sun, J., Dong, C., Wang, R., Gu, X., & Zhao, C. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.3c02509 · Cited by 14 · see citing works
Self-citationRecent advance in dual-functional luminescent probes for reactive species and common biological ions
Li, J., & Xie, X. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03792-9 · Cited by 14 · see citing works
Self-citationDong, C., Zhu, T., Sun, J., Dong, X., Sun, L., Gu, X., & Zhao, C. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c04513 · Cited by 13 · see citing works
Self-citationDong, X., Wu, H., Zhang, Z., Sun, J., Dong, C., Sun, L., Wang, R., Gu, X., & Zhao, C. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00264 · Cited by 13 · see citing works
Self-citationThe Application of Hydrogen Sulfide Fluorescent Probe in Food Preservation, Detection and Evaluation
Chen, S., Zhao, X., & Zhou, L. (2024) · Molecules · doi:10.3390/molecules29163973 · Cited by 13 · see citing works
Li, Z., Zhou, M., Zhao, L., Hu, W., Wang, X., Wei, H., Tong, X., Yao, C., Li, X., Zhang, Y., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155081 · Cited by 13 · see citing works
Zhao, G., Dai, H., Zhou, R., Zhang, G., Chen, H., Ma, D., Tian, W., Ban, X., Jiang, W., & Sun, Y. (2022) · Organic Electronics · doi:10.1016/j.orgel.2022.106530 · Cited by 13 · see citing works
Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells
Liang, W., Zhang, Y., Xiong, S., & Su, D. (2023) · Chemosensors · doi:10.3390/chemosensors11060333 · Cited by 12 · see citing works
An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging
Tang, X., Zhang, H.-N., Wang, W., & Wang, Q. (2024) · Molecules · doi:10.3390/molecules29102386 · Cited by 12 · see citing works
Dvorak, T., Hernandez-Sandoval, H., Cheku, S., González, M. M. V., Borer, L., Grieser, R., Carlson, K. A., & Cao, H. (2025) · Biosensors · doi:10.3390/bios15030174 · Cited by 11 · see citing works
Liu, Y., Tang, Q., Zhang, Y., Xu, M., Yao, Y. S., Qin, Y., Liu, Q., & Wu, L. J. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c00141 · Cited by 11 · see citing works
Huang, X., Zhang, S., Liu, Z., Cao, W., Li, G., Gao, W. Z., & Tang, B. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04267 · Cited by 11 · see citing works
NIR‐II Fluorescent Probe for Detecting Trimethylamine Based on Intermolecular Charge Transfer
Zhao, S., Xu, M., Liu, R., Xue, Y., Nie, J., & Chang, Y. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202200113 · Cited by 11 · see citing works
Yang, Z., Yang, Z.-C., Zhao, J., Fu, A.-X., Mao, G., Hu, L., Ouyang, J., & Li, C. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c04537 · Cited by 10 · see citing works
Wu, L., Zeng, W., Ishigaki, Y., Zhang, J., Bai, H., Harimoto, T., Suzuki, T., & Ye, D. (2022) · Angewandte Chemie · doi:10.1002/ange.202209248 · Cited by 10 · see citing works
An activatable fluorescent probe for imaging endogenous nitric oxide via the eNOS enzymatic pathway
Ouyang, Z., Ma, M., Yin, K., Guo, N., Fu, W. G., Guo, W., & Gu, X. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.128544 · Cited by 9 · see citing works
Reactive Species-Activatable AIEgens for Biomedical Applications
Kang, X., Li, Y., Yin, S., Li, W., & Qi, J. (2022) · Biosensors · doi:10.3390/bios12080646 · Cited by 9 · see citing works
Zhang, Z.-H., Zhang, X., Wang, P., Xu, S.-H., Liang, Z., Ye, C., & Wang, X. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.124834 · Cited by 8 · see citing works
Rationally designed fluorescent probes using target specific cascade reactions
Wang, R., Wang, X., Gu, X., Liu, Y., & Zhao, C. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.133282 · Cited by 8 · see citing works
Self-citationAn activatable near-infrared fluorescent probe for tracking nitroxyl in vitro and in vivo
Zhou, Z., Xia, X., Li, Z., Zhou, T., Wang, E., Ma, C., Lu, C., Nie, J., Yang, G., Wang, J., et al. (2022) · Dyes and Pigments · doi:10.1016/j.dyepig.2022.110945 · Cited by 7 · see citing works
Huang, Y., Wang, L., Huang, Q., Hu, B., Liu, Q., Wang, J., Shen, X., & Chen, H. (2025) · Chinese Journal of Chemistry · doi:10.1002/cjoc.70160 · Cited by 7 · see citing works
Self-citationLu, X., Wu, M., Wang, S., Qin, J., & Li, P. (2021) · Talanta · doi:10.1016/j.talanta.2021.123058 · Cited by 7 · see citing works
Sun, L., Wang, X., Chen, R., Dong, X., Sun, J., Dong, C., Xie, H., Gu, X., & Zhao, C. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02920d · Cited by 6 · see citing works
Self-citationHuang, H., Zhou, G., Meng, Z., Wang, X., Wang, Z., & Yang, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136018 · Cited by 6 · see citing works
Mitochondria–Nucleus Migration Probe for Ultrasensitive Monitoring of mtDNA Damage in Living Cells
Yu, Z., Pan, W., Yang, X., Tian, M., Zhang, J., Liu, H., Yang, L., Liu, X., Yan, M., & Xu, S. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04862 · Cited by 6 · see citing works
Self-citationChen, F., Du, C., Wang, Y., Zhu, J. S., Cheng, G., Li, K.-B., Han, D., & Wu, X. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.342648 · Cited by 6 · see citing works
Zheng, Z., Gong, S., Li, Q., Zhang, S., & Feng, G. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110191 · Cited by 5 · see citing works
Wang, X., Duan, J., Gao, H., Niu, Z., Zhang, C., Jiang, Z., & Liu, Z. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136713 · Cited by 5 · see citing works
Li, Z., Liu, X., Zhang, Y., Tong, X., Liu, J., Lei, Y., Guo, P., Liang, W., Zhou, M., & Yang, S. (2025) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2025.127415 · Cited by 4 · see citing works
Self-citationA sensitive and ratiometric fluorescent probe for imaging cytosolic H 2 S generation
Zhang, Y., Chen, Y., Shi, X., Bai, Y., He, W., & Guo, Z. (2022) · New Journal of Chemistry · doi:10.1039/d2nj04533h · Cited by 4 · see citing works
Zhao, S., Xue, Y., Hu, L., Sun, F., Nie, J., & Chang, Y. (2023) · ChemistrySelect · doi:10.1002/slct.202300554 · Cited by 4 · see citing works
An aggregation-induced fluorescence probe for H2S and its application in living cells
Shang, Y.-F., Wang, X., Wei, B.-Q., Wu, M., Jiang, Z.-Y., & Wu, X. (2024) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2024.116036 · Cited by 3 · see citing works
Xu, J., Li, X., Luo, Z., Li, J., Yang, S., & Zhang, T. (2024) · Small Methods · doi:10.1002/smtd.202400122 · Cited by 3 · see citing works
Self-citationMolecular Imaging of Nitric Oxide Surrogates with Organelle‐Specific Fluorescent Probes
Yadav, R., Sanukhan, R., Kalita, N., Mendiratta, S., Sivaramakrishnan, S., Murugan, S., & Samanta, A. (2024) · Chemistry - An Asian Journal · doi:10.1002/asia.202401237 · Cited by 2 · see citing works
Sun, S., Yuan, H., Hu, H., Feng, J., Shi, N., & Wang, Y. (2025) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2025.118409 · Cited by 1 · see citing works
Zhao, G., Jiang, W., Dai, H., Zhou, R., Zhang, G., Chen, H., Ma, D., Tian, W., Ban, X., & Sun, Y. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4046005
Demchenko, A. P. (2023) · Springer eBooks · doi:10.1007/978-3-031-19089-6_16
- Authors
- Zhu, T., Ren, N., Liu, X., Dong, Y., Wang, R., Gao, J., Sun, J., Zhu, Y., Wang, L., Fan, C., Tian, H., Li, J., & Zhao, C.
- Affiliations
- East China University of Science and Technology (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Li, Jiang
- Zhao, Chunchang
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-03-03
- Volume
- 60
- Issue
- 15
- Pages
- 8450-8454
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3124932286
- Cited by
- 106
- References
- 54
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 26 · 2023: 20 · 2022: 29 · 2021: 10
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21672062, 21874043)
- Science and Technology Commission of Shanghai Municipality (19JC1410300)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- nitric oxide, hydrogen sulfide, gasotransmitters, NIR-II fluorescence, S-nitrosylation, transnitrosation, intracellular dynamics, water-soluble quantum dots, intracellular imaging
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