Cited by 106Sulfur Compounds in BiologyMolecular Sensors and Ion DetectionAdvanced Fluorescence Microscopy Techniques

Probing the Intracellular Dynamics of Nitric Oxide and Hydrogen Sulfide Using an Activatable NIR II Fluorescence Reporter

Zhu, Tianli, Ren, Ning, Liu, Xia, Dong, Yan, Wang, Rongchen, Gao, Jinzhu, Sun, Jie, Zhu, Ying +5 more·2021·Angewandte Chemie International Edition

Abstract

Understanding the complex interplay among gasotransmitters is of great significance but remains technically challenging. In this study, we present the design and synthesis of a dually responsive BOD‐NH‐SC reporter for probing the dynamic and alternating existence of NO and H 2 S in living cells. This designed reporter can repeatedly cycle S‐nitrosation and transnitrosation reactions when successively treated with NO and H 2 S, thus affording the interchange of NIR fluorescence at 645 nm (NO) and NIR II fluorescence at 936 nm (H 2 S). In light of this unique fluorescence alternation between two colors, we synthesized water‐soluble BOD‐NH‐SC dots to visualize the intracellular dynamics of NO and H 2 S. These molecular probes thus provide a toolbox to elucidate the interplaying roles of NO and H 2 S in the complex interaction networks of various signal transduction pathways.

Integrity signals

Registry

Crossref · 10.1002/anie.202015650

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Installing orthogonal reactive motifs on the BODIPY scaffold achieves ratiometric and reversible response behavior.

    “This design highlighted the principle of installing orthogonal reactive motifs on the BODIPY scaffold to achieve ratiometric and reversible response behavior.”
  • BOD-NH-SC enabled precise monitoring of the alternating presence of NO and H2S in living cells.

    “enabling precise monitoring of the alternating presence of NO and H2S in living cells.”
  • BOD-NH-SC exhibited reversible fluorescence switching between NIR-I (655 nm) and NIR-II (936 nm) emissions.

    “The probe exhibited reversible fluorescence switching between NIR-I (655 nm) and NIR-II (936 nm) emissions”
  • Zhao et al. developed a dual-stimulus-responsive probe BOD-NH-SC integrating an N-methyl-2-methoxyaniline moiety for selective NO recognition and a 4-nitrophenylethanol-substituted BODIPY group for H2S detection.

    “Zhao et al. developed a dual-stimulus-responsive probe (BOD-NH-SC) that integrated an N-methyl-2-methoxyaniline moiety for selective NO recognition and a 4-nitrophenylethanol-substituted BODIPY group for H2S detection158.”

Cites

Flagged first, then by citations

1 of the 54 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Zhu, T., Ren, N., Liu, X., Dong, Y., Wang, R., Gao, J., Sun, J., Zhu, Y., Wang, L., Fan, C., Tian, H., Li, J., & Zhao, C.
Affiliations
  • East China University of Science and Technology (CN)
  • Chinese Academy of Sciences (CN)
  • Shanghai Jiao Tong University (CN)
Corresponding author
  • Li, Jiang
  • Zhao, Chunchang
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2021-03-03
Volume
60
Issue
15
Pages
8450-8454
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W3124932286
Cited by
106
References
54
Citations by year
2026: 5 · 2025: 16 · 2024: 26 · 2023: 20 · 2022: 29 · 2021: 10
FWCI
8.76
Type
journal article
Language
en
Open access
closed
Locations
  • Angewandte Chemie International Edition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (21672062, 21874043)
  • Science and Technology Commission of Shanghai Municipality (19JC1410300)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Keywords
nitric oxide, hydrogen sulfide, gasotransmitters, NIR-II fluorescence, S-nitrosylation, transnitrosation, intracellular dynamics, water-soluble quantum dots, intracellular imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review