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Cited by 662

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

Open access
Lan, Guangxu, Ni, Kaiyuan, Xu, Ziwan, Veroneau, Samuel S., Song, Yang, Lin, Wenbin·2018·Journal of the American Chemical Society
DOI 10.1021/jacs.8b01072
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Abstract

Immunotherapy has become a promising cancer therapy, but only works for a subset of cancer patients. Immunogenic photodynamic therapy (PDT) can prime cancer immunotherapy to increase the response rates, but its efficacy is severely limited by tumor hypoxia. Here we report a nanoscale metal-organic framework, Fe-TBP, as a novel nanophotosensitizer to overcome tumor hypoxia and sensitize effective PDT, priming non-inflamed tumors for cancer immunotherapy. Fe-TBP was built from iron-oxo clusters and porphyrin ligands and sensitized PDT under both normoxic and hypoxic conditions. Fe-TBP mediated PDT significantly improved the efficacy of anti-programmed death-ligand 1 (α-PD-L1) treatment and elicited abscopal effects in a mouse model of colorectal cancer, resulting in >90% regression of tumors. Mechanistic studies revealed that Fe-TBP mediated PDT induced significant tumor infiltration of cytotoxic T cells.

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Crossref · 10.1021/jacs.8b01072

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Metadata

Authors
Lan, G., Ni, K., Xu, Z., Veroneau, S. S., Song, Y., & Lin, W.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2018-04-18
Volume
140
Issue
17
Pages
5670-5673
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/jacs.8b01072
OpenAlex
W2801287827
Cited by
662
References
3
FWCI
34.45
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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